2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W089856
    Chlorobutanol hemihydrate
    		Inhibitor 99.97%
    Chlorobutanol hemihydrate is an antimicrobial agent with oral activity, also possessing preservative effects. Chlorobutanol hemihydrate exhibits resistance to a variety of Gram-positive and Gram-negative bacteria, as well as several fungal spores and fungi, and is widely used in the food and cosmetics industries.
    Chlorobutanol hemihydrate
  • HY-B1643
    Ethyl Vanillate
    		Inhibitor 99.87%
    Ethyl Vanillate is a fungicidal agent. Ethyl Vanillate inhibits 17β-HSD2 with an IC50 1.3 µM.
    Ethyl Vanillate
  • HY-W020043
    Pyribencarb
    		Inhibitor 98.80%
    Pyribencarb is a benzylcarbamate-type fungicide, which is active against a wide range of plant pathogenic fungi. Pyribencarb is a potent Qo inhibitor of cytochrome b. Pyribencarb is especially active against Botrytis cinerea and Sclerotinia sclerotirum.
    Pyribencarb
  • HY-123230R
    Trifloxystrobin (Standard)
    		Inhibitor
    Trifloxystrobin (Standard) is the analytical standard of Trifloxystrobin. This product is intended for research and analytical applications. Trifloxystrobin (CGA 279202) is a type of fungicide. Trifloxystrobin has toxicity, antiparasitic activity and induce apoptosis, oxidative stress and DNA damage. Trifloxystrobin can be used for the reaesrch of fungal diseases.
    Trifloxystrobin (Standard)
  • HY-W775091
    Isofetamid
    		Inhibitor 99.38%
    Isofetamid (IKF-5411) is a succinate dehydrogenase inhibitor and a fungicide. Isofetamid exhibits good control effects against various fungal diseases such as gray mold, white mold, and powdery mildew. Isofetamid is promising for research of plant fungal diseases.
    Isofetamid
  • HY-B1843
    Fuberidazole
    		Inhibitor 99.87%
    Fuberidazole (BAY 33172; Furidazole) is a fungicide. Fuberidazole shows a synergistic effect with cucurbituril (CB) macromolecules, such as CB7 and CB8. Studies have shown that, CB8 induces pKa shifts on Fuberidazole. Fuberidazole significantly inhibits the growth of B. cinerea.
    Fuberidazole
  • HY-U00007A
    Stilbamidine dihydrochloride
    		Inhibitor
    Stilbamidine dihydrochloride is a diamidine compound derived from Stilbene and used chiefly in the form of its crystalline isethionate salt in treating various fungal infections.
    Stilbamidine dihydrochloride
  • HY-N3340
    Macrocarpal I
    		Inhibitor
    Macrocarpal I is a phloroglucinol coupled sesquiterpenoid with antifungal activity. Macrocarpal I against C. glabrata with an IC50 value of 0.75 μg/mL. Macrocarpal I can be isolated from the juvenile leaves of E. maideni.
    Macrocarpal I
  • HY-17006R
    Caspofungin diacetate (Standard)
    		Inhibitor
    Caspofungin (diacetate) (Standard) is the analytical standard of Caspofungin (diacetate). This product is intended for research and analytical applications. Caspofungin (MK-0991) diacetate is a potent antifungal agent. Caspofungin diacetate inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan.
    Caspofungin diacetate (Standard)
  • HY-W654330
    Pyraclostrobin-d6
    		Inhibitor 99.90%
    Pyraclostrobin-d6 is deuterium-labeled Pyraclostrobin (HY-N6626).
    Pyraclostrobin-d<sub>6</sub>
  • HY-138145
    8-Acetyl-7-hydroxycoumarin
    		Inhibitor 99.78%
    8-Acetyl-7-hydroxycoumarin is a coumarin-like compound found in Mexican patchouli (Tagetes lucida) that has anti-bacterial and anti-fungal activities.
    8-Acetyl-7-hydroxycoumarin
  • HY-W019803
    Diclobutrazol
    		Inhibitor 99.20%
    Diclobutrazol, a systemic fungicide, is highly active against rusts, powdery mildews, and other fungal phytopathogens. Diclobutrazol can be used as a pesticide to control of various crop diseases.
    Diclobutrazol
  • HY-123351
    Kievitone
    		Inhibitor 99.67%
    Kievitone, an isoflavanone, could be isolated from hypocotyls of Phaseolus vulgaris L. infected with Rhizoctonia solani Kühn. Kievitone has antifungal activity and antitumor activity.
    Kievitone
  • HY-N7023
    7-Prenyloxycoumarin
    		99.87%
    7-Prenyloxycoumarin (7-O-Prenylumbelliferone) is a secondary metabolite from the endophytic fungus of Annulohypoxylon ilanense.
    7-Prenyloxycoumarin
  • HY-121004
    Bikaverin
    		Inhibitor
    Bikaverin (Lycopersin) is a reddish pigment produced by different fungal species. Bikaverin shows antibiotic properties against certain protozoa and fungi.
    Bikaverin
  • HY-N8284
    Tomentosin
    		Inhibitor 98.95%
    Tomentosin is an orally active natural sesquiterpenoid lactone. Tomentosin exhibits multiple activities such as anti-tumor, anti-fungal, anti-inflammatory, anti-oxidant and neuroprotective effects. Tomentosin can inhibit tumor cell proliferation, migration and invasion, and induce apoptosis. Tomentosin can be used in the research of tumors, inflammation and nervous system diseases.
    Tomentosin
  • HY-W392100A
    Polycaprolactone diol (MW 530)
    Polycaprolactone diol (MW 530) (PCL-diol (MW 530)) is a poly (ε-caprolactone) diol with an average molecular weight of 530 g·mol−1, which serves as a monomer for biodegradable network elastic polyesters. Network polyester films undergo enzymatic hydrolysis by Rhizopus delemar lipase.
    Polycaprolactone diol (MW 530)
  • HY-17395S
    Terbinafine-d3 hydrochloride
    		Inhibitor 99.87%
    Terbinafine-d3 hydrochloride is the deuterium labeled Terbinafine hydrochloride. Terbinafine hydrochloride (TDT 067 hydrochloride) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM. Terbinafine hydrochloride also antibacterial activity against certain Gram-positive and Gram-negative bacteria.
    Terbinafine-d<sub>3</sub> hydrochloride
  • HY-W109523
    2-Butylbenzo[d]isothiazol-3(2H)-one
    		Inhibitor
    2-Butylbenzo[d]isothiazol-3(2H)-one is a bioactive compound with potent antibacterial and antifungal activity. 2-Butylbenzo[d]isothiazol-3(2H)-one is often used as a pesticide ingredient in agriculture to protect crops from diseases. 2-Butylbenzo[d]isothiazol-3(2H)-one is also used in coatings to prevent the growth of mold and algae. 2-Butylbenzo[d]isothiazol-3(2H)-one is also used as a preservative in personal care products to extend the shelf life of the product.
    2-Butylbenzo[d]isothiazol-3(2H)-one
  • HY-B0849R
    Azoxystrobin (Standard)
    		Inhibitor
    Azoxystrobin (Standard) is the analytical standard of Azoxystrobin. This product is intended for research and analytical applications. Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis.
    Azoxystrobin (Standard)
Cat. No. Product Name / Synonyms Application Reactivity