HDAC Inhibitor

Tubastatin A (GMP) is the Tubastatin A (HY-13271A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Tubastatin A is a potent and selective HDAC6 inhibitor with an IC₅₀ of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). Tubastatin A also inhibits HDAC10 and metallo-β-lactamase domain-containing protein 2 (MBLAC2).

DD0-2363 (Compound 32d) is a dual-target inhibitor of WDR5-MLL1/HDAC. DD0-2363 inhibits cells proliferation and induces apoptosis in acute myeloid leukemia cells. DD0-2363 has antitumor activity and can be used in the research of acute myeloid leukemia.

HDAC-IN-80 (compund 5) is a selective class I HDAC inhibitor.

Tinostamustine hydrochloride (EDO-S101 hydrochloride) is a compound with anti-multiple myeloma activity and the ability to promote CD38 expression. Tinostamustine hydrochloride enhances the sensitivity of tumor cells to the anti-CD38 monoclonal antibody daratumumab by increasing the acetylation level of histone H3. Tinostamustine hydrochloride can increase the expression of MICA and MICB, thereby activating NK cells. Tinostamustine hydrochloride can significantly delay tumor growth and improve the survival rate of mice.

Hdac2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hdac2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hdac6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hdac6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sodium butyrate (Standard) is the analytical standard of Sodium butyrate (HY-B0350A). This product is intended for research and analytical applications. Sodium Butyrate (sodium butanoate) is an inhibitor of HDAC, possessing anti-tumor activity.

Largazole thiol, the active form of Largazole (HY-13906), is a potent, selective and brain-penetrant class I HDAC inhibitor. Largazole thiol. Largazole thiol exerts antitumor and neuroprotective effects. Largazole thiol can be used for research of Glioblastoma.

HDAC6-IN-57 (compound 9c) is an HDAC6 inhibitor with an IC₅₀ value of 7 nM. HDAC6-IN-57 inhibits 60 cancer cell lines with a mean GI₅₀ of 2.64 μM while exhibiting significantly lower cytotoxicity towards non-tumor cell lines.

XP5 is a potent, orally active HDAC6 inhibitor with an IC₅₀ of 31 nM. XP5 displays high antiproliferative activity against various cancer cell lines including the HDACi-resistant YCC3/7 gastric cancer cells (IC50=0.16-2.31 μM). XP5 enhances antitumor immunity when combined with a PD-L1 inhibitor in melanoma.

HDAC-IN-65 ( compound 6) is a selective histone deacetylase (HDAC) inhibitor with IC₅₀ value of 2.5μM. HDAC-IN-65 is a prodrug with very good bioreductive properties.

HDAC8-IN-12 (compound 5k) is a non-hydroxamic acid, selective inhibitor of HDAC8 (IC₅₀: 0.12 nM) and a potent inhibitor of breast cancer. HDAC8-IN-12 triggers anti-tumor immunity by activating T cells, increasing the proportion of M1 macrophages and decreasing the proportion of M2 macrophages. HDAC8-IN-12 (50 mg/kg) exerts tumor suppressive effects in an orthotopic mouse model of breast cancer.

Dihydrochlamydocin is a histone deacetylases (HDAC) inhibitor. Dihydrochlamydocin shows strong cytostatic activity towards mastocytoma cells.

T326 is a potent and selective HDAC3 inhibitor, with an IC₅₀ of 0.26 μM. T326 can be used for the research of cancer and HIV infection.

HDAC8-IN-5 (Compound 6a) is a HDAC8 inhibitor (IC₅₀: 28 nM). HDAC8-IN-5 can be used for cancer research.

Romidepsin (GMP) (FK 228 (GMP)) is Romidepsin (HY-15149) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Romidepsin (FK 228) is a Histone deacetylase (HDAC) inhibitor with anti-tumor activities. Romidepsin (FK 228) inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC₅₀s of 36 nM, 47 nM, 510 nM and 1.4 μM, respectively. Romidepsin (FK 228) is produced by Chromobacterium violaceum, induces cell G2/M phase arrest and apoptosis.

Top/HDAC-IN-1 (Compound 29b) is a topoisomerase/HDAC dual inhibitor with IC₅₀s of 18, 230, 790, 87, and 5250 nM for HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8, respectively. Top/HDAC-IN-1 exhibits potent antitumor activities against the HCT116 cell line with the IC₅₀ of 180 nM. Top/HDAC-IN-1 efficiently induces apoptosis with G2 cell cycle arrest in HCT116 cells.

Tubulin/HDAC-IN-2 (Compound II-19k) is a dual inhibitor of Tubulin and HDAC, with an IC₅₀ of 0.403 μM, 0.591μM, 3.552μM, 0.459μM for HDAC1/2/3/6. Tubulin/HDAC-IN-2 blocks cell cycle arrest at G2 phase, induces cell apoptosis. Tubulin/HDAC-IN-2 inhibits the growth of hematoma and solid tumor cells, reduces tumor metastasis, and also inhibits tumor growth in a liver tumor allograft mouse model.