2. Signaling Pathways
  3. Anti-infection
  4. HIV

HIV

Human immunodeficiency virus

HIV

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HIV (Human immunodeficiency virus) is a lentivirus (a subgroup of retrovirus) that causes the acquired immunodeficiency syndrome (AIDS), a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Infection with HIV occurs by the transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk. Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells. HIV infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages, and dendritic cells. HIV infection leads to low levels of CD4+ T cells through a number of mechanisms, including apoptosis of uninfected bystander cells, direct viral killing of infected cells, and killing of infected CD4+ T cells by CD8 cytotoxic lymphocytes that recognize infected cells. When CD4+ T cell numbers decline below a critical level, cell-mediated immunity is lost, and the body becomes progressively more susceptible to opportunistic infections.

HIV Isoform Specific Products:

HIV Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-104012R
    Islatravir (Standard)
    		Inhibitor
    Islatravir (Standard) is the analytical standard of Islatravir (HY-104012). This product is intended for research and analytical applications. Islatravir (MK-8591) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively. Islatravir is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Islatravir (Standard)
  • HY-B1285R
    Dimercaprol (Standard)
    		Inhibitor
    Dimercaprol (Standard) is the analytical standard of Dimercaprol. This product is intended for research and analytical applications. Dimercaprol (2,3-Dimercapto-1-propanol) is an anti-heavy metal-poisoning agent, which exhibits anti-HIV activity. Dimercaprol can be used for the study for arsenic, mercury, gold, lead, antimony, and other toxic metal poisoning.
    Dimercaprol (Standard)
  • HY-50912R
    Plerixafor octahydrochloride (Standard)
    		Inhibitor
    Plerixafor (octahydrochloride) (Standard) is the analytical standard of Plerixafor (octahydrochloride). This product is intended for research and analytical applications. Plerixafor octahydrochloride (AMD3100 octahydrochloride) is a selective CXCR4 antagonist with an IC50 of 44 nM.
    Plerixafor octahydrochloride (Standard)
  • HY-118711
    HI-346
    		Inhibitor
    HI-346 is a non-nucleoside reverse transcriptase inhibitor (NNRTI) for HIV-1 with an IC50 value against the HIV-1 virus strain (HTLV-IIIB) of 3 nM. HI-346 is a vaginal bactericidal contraceptive agent, with its sperm-killing activity having an EC50 value of 42 μM. HI-346 shows no cytotoxicity to normal cells at effective concentrations. HI-346 can be used in anti-HIV-1 and contraceptive research.
    HI-346
  • HY-106971
    PD 161374
    		Inhibitor
    PD 161374 is an inhibitor targeting the HIV-1 nucleocapsid protein NCp7. PD 161374 primarily acts on the early stages of viral replication, inhibiting the completion of reverse transcription without affecting viral entry or later assembly. PD 161374 remains active against HIV-1, HIV-2, SIV, and drug-resistant strains. PD 161374 can be used to study antiretroviral agents.
    PD 161374
  • HY-114731
    Adenallene
    		Inhibitor
    Adenallene, a nucleoside analogue, is an anti-HIV compound. Adenallene inhibits replication and cytopathic effect of HIV-1 and HIV-2.
    Adenallene
  • HY-B0116A
    Stavudine sodium
    		Inhibitor 99.40%
    Stavudine (d4T) sodium is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Stavudine sodium has activity against HIV-1 and HIV-2. Stavudine sodium also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine sodium reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine sodium induces apoptosis.
    Stavudine sodium
  • HY-13231R
    CDK9-IN-1 (Standard)
    		Inhibitor
    CDK9-IN-1 (Standard) is the analytical standard of CDK9-IN-1. This product is intended for research and analytical applications. CDK9-IN-1 is a novel, selective CDK9 inhibitor for the treatment of HIV infection, with an IC50 of 39 nM for CDK9/CycT1, extracted from reference, compound 87.
    CDK9-IN-1 (Standard)
  • HY-N15283
    Baculiferin A
    		Inhibitor
    Baculiferins A is a DOPA-derived pyrrole alkaloid. Baculiferins A can be isolated from the Chinese marine sponge Iotrochota baculifera. Baculiferins A have anti-HIV activity.
    Baculiferin A
  • HY-15232S2
    Tenofovir alafenamide-d6
    		Inhibitor
    Tenofovir alafenamide-d6 (GS-7340-d6) is deuterium labeled Tenofovir alafenamide. Tenofovir alafenamide (GS-7340) is an investigational oral proagent of Tenofovir. Tenofovir is a HIV-1 nucleotide reverse transcriptase inhibitor.
    Tenofovir alafenamide-d<sub>6</sub>
  • HY-100260
    beta-L-D4A
    		Inhibitor 99.71%
    beta-L-D4A is a nucleoside HIV-1 reverse transcriptase inhibitor.
    beta-L-D4A
  • HY-B0372AR
    Bromhexine hydrochloride (Standard)
    		Inhibitor
    Bromhexine (hydrochloride) (Standard) is the analytical standard of Bromhexine (hydrochloride). This product is intended for research and analytical applications. Bromhexine hydrochloride is a potent and specific TMPRSS2 protease inhibitor with an IC50 of 0.75 μM. Bromhexine hydrochloride can prevent and manage SARS-CoV-2 infection. Bromhexine hydrochloride is an autophagy agonist. Bromhexine hydrochloride is a mucolytic cough suppressant and has the potential for a range of respiratory conditions.
    Bromhexine hydrochloride (Standard)
  • HY-N15262
    Schinlignan B
    		Inhibitor
    Schinlignan B (Angeloylgomisin P) is a lignan with antioxidant, anti-HIV, anti-HBV activities, which is found in plants of the Schisandra genus. Schinlignan B is promising for research of antioxidant-associated diseases.
    Schinlignan B
  • HY-13516R
    Aloperine (Standard)
    		Inhibitor
    Aloperine (Standard) is the analytical standard of Aloperine. This product is intended for research and analytical applications. Aloperine is an alkaloid in sophora plants such as Sophora alopecuroides L, which has shown anti-cancer, anti-inflammatory and anti-virus properties. Aloperine is widely used to treat patients with allergic contact dermatitis eczema and other skin inflammation in China. Aloperine induces apoptosis and autophagy in HL-60 cells.
    Aloperine (Standard)
  • HY-153782
    GSK878
    		Inhibitor
    GSK878 is a highly potent, long-acting HIV-1 inhibitor with the EC50 of 39 pM.
    GSK878
  • HY-N12082
    HIV-IN-8
    		Inhibitor
    HIV-IN-8 (Compound 9) is a HIV inhibitor. HIV-IN-8 inhibits HIV replication with an EC50 of 13 μg/mL.
    HIV-IN-8
  • HY-N15327
    Hyrtiosal
    		Inhibitor
    Hyrtiosal, found in the marine sponge Hyrtios erectus, is an inhibitor of the N-terminal domain (NTD) of HIV-1 integrase (HIV-1 IN) with an IC50 value of 9.60-0.86 μM. Hyrtiosal binds to the Ser17, Trp19, and Lys34 sites on the NTD of HIV-1 IN, inhibiting the binding of HIV-1 viral DNA to integrase and interfering with the formation of the pre-integrated complex of HIV-1. Hyrtiosal is promising for research of anti-HIV agents.
    Hyrtiosal
  • HY-126363S
    Ditiocarb-d10
    		Inhibitor
    Ditiocarb-d10 (Diethyldithiocarbamic acid-d10) is the deuterium labeled Ditiocarb (HY-126363). Ditiocarb (Diethyldithiocarbamic acid) is an accelerator of the rate of copper cementation. Ditiocarb (Diethyldithiocarbamic acid) reduces the incidence of HIV infection, and also enhances adjuvant immunoresearch of high risk breast cancer.
    Ditiocarb-d<sub>10</sub>
  • HY-163177
    HIV-1 inhibitor-63
    		Inhibitor
    HIV-1 inhibitor-63 (compound S17) is a potent HIV-1 inhibitor. HIV-1 inhibitor-63 inhibits integrase-Ku70 complex formation with an IC50 value of 12 µM. HIV-1 inhibitor-63 inhibits HIV-1 post-integration DNA repair.
    HIV-1 inhibitor-63
  • HY-174417
    NNRT-IN-10
    		Inhibitor
    NNRT-IN-10 is a potent, selective and orally active non-nucleoside HIV-1 reverse transcriptase (NNRTI) inhibitor with with an EC50 values ranging from 1.16 to 18.3 nM for HIV and its mutant strains. NNRT-IN-10 exhibits good pharmacokinetic properties and favorable safety profiles. NNRT-IN-10 can be used for the study of AIDS, caused by HIV-1.
    NNRT-IN-10
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
HIV Isoform Comparison

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