2. Signaling Pathways
  3. Autophagy
  4. LRRK2
  5. LRRK2 Degrader

LRRK2 Degrader

LRRK2 Degraders (6):

Cat. No. Product Name Effect Purity
  • HY-171801
    PROTAC LRRK2 Degrader-1
    		Degrader
    PROTAC LRRK2 Degrader-1 (compound 18) is a leucine-rich repeat kinase 2 (LRRK2) PROTAC degrader with an IC50 value less than 10 nM. PROTAC LRRK2 Degrader-1 can be used in the research of Parkinson's disease.
  • HY-186110
    PROTAC LRRK2 Degrader-5
    		Degrader
    PROTAC LRRK2 Degrader-5 Formula (V) is a LRRK2 PROTAC degrader. PROTAC LRRK2 Degrader-5 can be used for thet study of the diseases associated with LRRK2, such as Parkinson’s Disease (PD).
  • HY-163064
    CC-3240
    		Degrader 98.23%
    CC-3240 (compound 13) is a molecular glue degrader of CaMKK2 based on CC-8977, with the IC50 of 9 nM.
  • HY-178796
    PROTAC LRRK2 Degrader-4
    		Degrader
    PROTAC LRRK2 Degrader-4 is a PROTAC LRRK2 degrader with a DC50 of 0.79 nM. PROTAC LRRK2 Degrader-4 can be used for research in Parkinson’s disease and inflammation.
  • HY-178797
    PROTAC LRRK2 Degrader-3
    		Degrader
    PROTAC LRRK2 Degrader-3 (compound 6) is a PROTAC LRRK2 degrader with a DC50 of 0.17 nM. PROTAC LRRK2 Degrader-3 can be used for research in Parkinson’s disease and inflammation.
  • HY-171802
    PROTAC LRRK2 Degrader-2
    		Degrader
    PROTAC LRRK2 Degrader-2 is a PROTAC-based degrader targeting LRRK2 with a DC50 of 0.14 nM. PROTAC LRRK2 Degrader-2 recruits LRRK2 or its mutants to the cereblon E3 ubiquitin ligase, thereby mediating the targeted ubiquitination and subsequent proteasomal degradation of LRRK2. PROTAC LRRK2 Degrader-2 can be used in research related to Parkinson's disease.