LRRK2 Degrader

PROTAC LRRK2 Degrader-1 (compound 18) is a leucine-rich repeat kinase 2 (LRRK2) PROTAC degrader with an IC⁵⁰ value less than 10 nM. PROTAC LRRK2 Degrader-1 can be used in the research of Parkinson's disease.

JH-XII-03-02 is a potent and selective LRRK2 PROTAC degrader. JH-XII-03-02 can be used for parkinson's Disease (PD) research.

CC-3240 (compound 13) is a molecular glue degrader of CaMKK2 based on CC-8977, with the IC₅₀ of 9 nM.

PROTAC LRRK2 Degrader-4 is a PROTAC LRRK2 degrader with a DC₅₀ of 0.79 nM. PROTAC LRRK2 Degrader-4 can be used for research in Parkinson’s disease and inflammation.

PROTAC LRRK2 Degrader-3 (compound 6) is a PROTAC LRRK2 degrader with a DC₅₀ of 0.17 nM. PROTAC LRRK2 Degrader-3 can be used for research in Parkinson’s disease and inflammation.

PROTAC LRRK2 Degrader-5 Formula (V) is a LRRK2 PROTAC degrader. PROTAC LRRK2 Degrader-5 can be used for thet study of the diseases associated with LRRK2, such as Parkinson’s Disease (PD).

PROTAC LRRK2 Degrader-2 is a PROTAC-based degrader targeting LRRK2 with a DC₅₀ of 0.14 nM. PROTAC LRRK2 Degrader-2 recruits LRRK2 or its mutants to the cereblon E3 ubiquitin ligase, thereby mediating the targeted ubiquitination and subsequent proteasomal degradation of LRRK2. PROTAC LRRK2 Degrader-2 can be used in research related to Parkinson's disease.