MDM-2/p53 Inhibitor
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Solasodine hydrochloride
0 ImagesCat. No.: HY-W751400CAS No.: 6106-33-8Synonyms: Purapuridine hydrochloride; Solancarpidine hydrochloride; Solasodin hydrochlorideSolasodine (Purapuridine) hydrochloride is a steroidal alkaloid that occurs in plants of the Solanaceae family. Solasodine hydrochloride induces apoptosis by inhibiting the p53-MDM2 complex, p21Waf1/Cip1, and Bcl-2 proteins. Solasodine hydrochloride has neuroprotective, antifungal, hypotensive, anticancer, antiatherosclerotic, antiandrogenic and anti-inflammatory activities.
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(R)-NVP-CGM097
0 ImagesCat. No.: HY-15954CCAS No.: 2643938-26-3Synonyms: (R)-CGM097(R)-NVP-CGM097 is the R-enantiomer of NVP-CGM097 (HY-15954). NVP-CGM097 is a potent and selective MDM2 inhibitor with an IC50 of 1.7 nM for hMDM2.
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Bragsin2 (Standard)
0 ImagesCat. No.: HY-111550RCAS No.: 342795-08-8Bragsin2 (Standard) is the analytical standard of Bragsin2 (HY-111550). This product is intended for research and analytical applications. Bragsin2 is a potent, selective and noncompetitive nucleotide exchange factor BRAG2 inhibitor, with an IC50 of 3 μM. Bragsin2 binds at the interface between the PH domain of BRAG2 and the lipid bilayer, leads BRAG2 unable to activate lipidated Arf GTPase. Bragsin2 affects breast cancer stem cells.
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p53-MDM2-IN-3
0 ImagesCat. No.: HY-121893CAS No.: 1542066-74-9p53-MDM2-IN-3 (Compound 5s) is an orally active p53-MDM2 inhibitor with a Ki value of 0.25 μM. p53-MDM2-IN-3 exerts antitumor activity by inhibiting NF-κB pathway.
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Rhodojaponin VI
0 ImagesRhodojaponin VI is an orally active diterpenoid compound found in hododendron molle G. Don
(Ericaceae) (RM). Rhodojaponin VI binds rat N-Ethylmaleimide-sensitive fusion (NSF) with a Kd of 1.03 μM. Rhodojaponin VI blocks the MDM2-Notch1 signalling pathway by reducing MDM2 and Notch1 expression. Rhodojaponin VI indirectly reduces Cav2.2 current intensity by inhibiting NSF-mediated Cav2.2 trafficking. Rhodojaponin VI alleviates glomerulonephritis progression and podocyte injury in passive heymann nephritis rats. Rhodojaponin VI also has antinociceptive effects. Rhodojaponin VI can be used for the researches of heymann nephritis and pain.
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Conessine dihydrobromide
0 ImagesCat. No.: HY-107566ACAS No.: 5913-82-6Conessine dihydrobromide is an orally active and BBB-penetrable selective histamine H3 receptor antagonist. The pKi values of Conessine dihydrobromide for rat and human H3 receptors are 7.61 and 8.27, respectively. Conessine dihydrobromide is an inhibitor of the multidrug efflux pump system in Pseudomonas aeruginosa and can enhance the activity of antibiotics. Conessine dihydrobromide has antimalarial activity. Conessine dihydrobromide can also be used in the research of muscle atrophy.
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Hexamethylene bisacetamide (Standard)
0 ImagesSynonyms: HMBA (Standard)Hexamethylene bisacetamide (Standard) is the analytical standard of Hexamethylene bisacetamide. This product is intended for research and analytical applications. Hexamethylene bisacetamide (HMBA) is a differentiation inducer and selective bromine domain inhibitor that can differentiate across the blood-brain barrier. Hexamethylene bisacetamide can induce tumor cell differentiation and inhibit cell proliferation, showing antitumor activity. Hexamethylene bisacetamide induces apoptosis by Notch1, Bcl-2 and p53 signaling pathways. In addition, Hexamethylene bisacetamide improves the obesity phenotype of mice.
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Petunidin-3-O-glucoside chloride (Standard)
0 ImagesPetunidin-3-O-glucoside chloride (Standard) is the analytical standard of Petunidin-3-O-glucoside chloride (HY-N7832). This product is intended for research and analytical applications. Petunidin-3-O-glucoside chloride is a blood-brain barrier-penetrating tyrosinase inhibitor with an IC50 of 10.3 μM and a Ki of 9.0 μM. Petunidin-3-O-glucoside also acts as an α-glucosidase inhibitor with an IC50 of 218.2 µM. Petunidin-3-O-glucoside chloride inhibits the SIRT3/p53-mediated mitochondrial pathway and the PI3K/Akt-ERK pathway, suppresses glycolysis, and induces cell apoptosis. Petunidin-3-O-glucoside chloride scavenges ROS to exert antioxidant activity. It can be used in research related to glioblastoma multiforme, skin anti-aging and whitening, as well as obesity.
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MDM2-p53-IN-18
0 ImagesCat. No.: HY-161039CAS No.: 1818291-95-0MDM2-p53-IN-18 (Compd A-7b) is a MDM2-p53 interaction inhibitor.
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Nutlin-2
0 ImagesCat. No.: HY-130303CAS No.: 548472-76-0
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USP7-IN-20
0 ImagesCat. No.: HY-183942CAS No.: 2196246-28-1USP7-IN-20 is a highly selective USP7 inhibitor that binds allosterically to the allosteric pocket of USP7 in a non-competitive and reversible manner. USP7-IN-20 downregulates MDM2 protein levels and stabilizes p53, thereby inducing p21 expression and enhancing the ubiquitin-dependent degradation of MDM2. USP7-IN-20 effectively binds endogenous USP7 to inhibit cancer cell proliferation, and also induces apoptosis by promoting the cleavage of PARP and caspase 3. USP7-IN-20 can be widely used in cancer-related basic and translational research.
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MDM2-p53-IN-20
0 ImagesCat. No.: HY-161041CAS No.: 2095120-09-3MDM2-p53-IN-20 (Compd B-11j) is a synthetic MDM2-p53 interaction inhibitor that play an important role in cancer.
