MAO-B

Monoamine Oxidase B

MAO-B Related Products (161):

By Type:	Pan (53) Selective (75)

Cat. No.	Product Name	Effect	Purity

HY-152113

AChE/BChE/MAO-B-IN-3	Inhibitor
AChE/BChE/MAO-B-IN-3, an indan-1-one derivative, is a potent MAO-B inhibitor with an IC₅₀ of 0.0359 μM for human MAO-B. AChE/BChE/MAO-B-IN-3 is a potent AChE and BChE enzyme inhibitor, with IC₅₀s of 0.0473 μM and 0.0782 μM for human AChE and BChE enzyme, respectively. AChE/BChE/MAO-B-IN-3 shows significant antioxidant activity and has the potential for Alzheimer's disease (AD) research.

HY-158732

MAO-B-IN-33	Inhibitor
MAO-B-IN-33 (compound C3) is a potent, reversible and selective monoamine oxidase-B (MAO-B) inhibitor with an IC₅₀ of 0.021 μM and 26.805 μM for MAO-B and MAO-A, respectively. The selectivity of MAO-B-IN-33 is attributed to the steric clash arising from the residue differences between Phe208 (MAO-A) and Ile199 (MAO-B). MAO-B-IN-33 inhibits cerebral MAO-B activity and alleviates MPTP (HY-15608)-induced dopaminergic neuronal loss in the mouse. MAO-B-IN-33 has the potential for Parkinson's disease research.

HY-172461

MAO-IN-6	Inhibitor
MAO-IN-6 (Compound 3f) is a BBB permeable and reversible MAO-B inhibitor with an IC₅₀ of 0.09 μM. MAO-IN-6 also exhibits certain inhibitory activities against AChE and BChE, with IC₅₀ values of 4.48 μM and 17.03 μM, respectively. MAO-IN-6 has low cytotoxicity and can be used in the research of Alzheimer's disease.

HY-152109

AChE/MAO-IN-1	Inhibitor
AChE/MAO-IN-1 (Compound D28) is a potent AChE, MAO-A and MAO-B inhibitor with IC₅₀s of 0.0248, 0.0409 and 0.1108 μM against human AChE, MAO-B and MAO-A, respectively.

HY-179126

BChE/MAO-A-IN-1	Inhibitor
BChE/MAO-A-IN-1 (compound 7j) is a BChE/MAO-A inhibitor. BChE/MAO-A-IN-1 exhibits inhibitory activity against BChE (IC₅₀ = 0.03 nM) and MAO-A (IC₅₀ = 0.32 nM), while also having inhibitory effects on MAO-B. BChE/MAO-A-IN-1 has good anti glycation, antioxidant activity, and low cytotoxicity. BChE/MAO-A-IN-1 can be used in the research of diabetes and Alzheimer's disease.

HY-146691

hMAO-B-IN-2	Inhibitor
hMAO-B-IN-2 (compound 6j) is an orally active, potent, selective and BBB penetrated and competitive reversible hMAO-B inhibitor, with an IC₅₀ of 4 nM. hMAO-B-IN-2 shows low toxicity and good neuroprotective effects in SH-SY5Y cell. hMAO-B-IN-2 can be used for alzheimer’s disease research. hMAO-B-IN-2 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-151208

MAO-B-IN-16	Inhibitor
MAO-B-IN-16 is a selective monoamine oxidase B (MAO-B) inhibitor, with an IC₅₀ of 1.55 µM. MAO-B-IN-16 can be used in the study of central nervous disorders, such as parkinson's disease.

HY-175524

BChE/MAO-B-IN-2	Inhibitor
BChE/MAO-B-IN-2 is a dual inhibitor of BChE (IC₅₀ = 0.05 μM, K_i = 0.01 μM) and MAO-B (IC₅₀ = 0.45 μM, K_i = 0.08 μM) with good blood-brain barrier permeability. BChE/MAO-B-IN-2 exhibits antioxidant activity, including DPPH radical scavenging, CUPRAC copper ion reduction, and superoxide anion scavenging. BChE/MAO-B-IN-2 can be used for the study of Alzheimer's disease (AD).

HY-N1638

1-Methyl-2-undecyl-4(1H)-quinolone	Inhibitor
1-Methyl-2-undecyl-4(1H)-quinolone is a potent, irreversible and selective inhibitor of type B monoamine oxidase (MAO-B). 1-Methyl-2-undecyl-4(1H)-quinolone shows a selective inhibition of MAO-B activity with the IC₅₀ and K_i values of 15.3 μM and 9.91 μM, respectively, but did not inhibit type A MAO (MAO-A) activity. Methyl-2-undecyl-4(1H)-quinolone, as a quinolone alkaloid, is isolated from fresh leaves and fruits of Evodia rutaecarpa HOOK. f. et THOMS.

HY-144756

LSD1-IN-15	Inhibitor
LSD1-IN-15 (compound 1b) is a potent LSD1 inhibitor. LSD1-IN-15 can inhibit LSD1-CoREST, MAO-A and MAO-B, with IC₅₀ values of 0.149, 0.028, and 0.327 μM, respectively. LSD1-IN-15 displays cell growth arrest in prostate cancer LNCaP cells, with an IC₅₀ of 9.9 μM.

HY-155137

CHBO4
CHBO4 is a potent, reversible, competitive, and selective hMAO-B inhibitor with an IC₅₀ value of 0.031 μM in CHBO subseries and an K_i value of 0.010 ± 0.005 μM. CHBO4 reduce cell damage by scavenging intracellular reactive oxygen species (ROS). CHBO4 can be used for Parkinson's Disease (PD) research.

HY-146762

MAO-B-IN-7	Inhibitor
MAO-B-IN-7 is a potent and blood-brain barrier permeable MAO-B and AChE inhibitor with IC₅₀s of 41 nM, 87 nM and 0.3 μM for human AChE, electric eel AChE and MAO-B, respectively. MAO-B-IN-7 can effectively alleviate oxidative stress and neuroinflammatory damage.

HY-131660

MAO-B-IN-54	Inhibitor
MAO-B-IN-54 is a selective, reversible and competitiv monoamine oxidase B (MAOB) inhibitor with a human IC₅₀ of 0.052 μM and a K_i of 0.028 μM. MAO-B-IN-54 shows weak activity MAOA. MAO-B-IN-54 occupies both the entrance and substrate cavity of MAOB, forming hydrophobic and hydrogen bonding interactions. MAO-B-IN-54 inhibits Aβ aggregation and ROS production. MAO-B-IN-54 can be used for the research of Alzheimer’s disease.

HY-184026

MAO-B-IN-58	Inhibitor
MAO-B-IN-58 (Compound 2e) is a reversible, selective MAO-B inhibitor with an IC₅₀ of 170 nM against rat MAO-B. MAO-B-IN-58 is applicable for the research of Parkinson's disease and Alzheimer's disease.

HY-147362

MAO-B-IN-14	Inhibitor
MAO-B-IN-14 (Compound 9) is a potent and selective monoamine oxidase-B (MAO-B) inhibitor with an IC₅₀ of 0.95 μM and a K_i of 0.55 μM against human MAO-B.

HY-W628136

MAO-B-IN-47	Inhibitor
MAO-B-IN-47 is a selective monoamine oxidase B (MAO-B) inhibitor with a K_i of 875 nM. MAO-B-IN-47 shows an IC₅₀ >100 μM for SH-SY5Y cells. MAO-B-IN-47 shows neuroprotective effect in 6-OHDA-treated SH-SY5Y cells. MAO-B-IN-47 can be used for the research of neurological disease, such as Parkinson’s disease (PD).

HY-152112

AChE/BChE/MAO-B-IN-2	Inhibitor
AChE/BChE/MAO-B-IN-2 is a potent AChE, BChE, and MAO-B enzymes inhibitor with IC₅₀ values of 48.2 nM, 83.9 nM, and 31.2 nM, respectively. AChE/BChE/MAO-B-IN-2 has significant antioxidant activity, and can be used for Parkinson’s disease research.

HY-W035384

MAO-B ligand-1	Inhibitor
MAO-B ligand-1 is a MAO-B inhibitor, with IC₅₀ values of 22.57 and 3.83 nM for hMAO-A and hMAO-B, respectively.

HY-152111

AChE/MAO-B-IN-3	Inhibitor
AChE/MAO-B-IN-3 (Compound D30) is a dual AChE and MAO-B inhibitor with IC₅₀s of 0.0257 μM and 0.0456 μM against human AChE and MAO-B, respectively. AChE/MAO-B-IN-3 can be used for the research of Alzheimer’s disease.

HY-146149

MAO-B-IN-11	Inhibitor
MAO-B-IN-11 (Compound 8c) is a potent monoamine oxidase B (MAO-B) inhibitor with an IC₅₀ of 1.3 μM. MAO-B-IN-11 shows a neuroprotective activity.

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