NO Synthase
Nitric oxide synthases; NOS
Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO synthases catalyze the oxidation of L-arginine to NO and L-citrulline. Mammals contain three NOS isoforms: neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS). NO produced from these different NOS isoforms is involved in a wide range of physiologic functions in the nervous, immune, and cardiovascular systems. Unregulated NO production can lead to pathologic conditions such as stroke, inflammation, and hypertension. Therefore, the control of NOS activity by isoform selective NOS inhibitors has great potential for therapeutic treatments of NO-related diseases.
NO Synthase Isoform Specific Products
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NO Synthase Inhibitors
(759)
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NO Synthase Agonists
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NO Synthase Antagonists
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NO Synthase Activators
(111)
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NO Synthase Modulators
(14)
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NO Synthase MDM2 Inhibitor
(1)
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NO Synthase Inducers
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NO Synthase Controls
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NO Synthase Substrates
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NO Synthase Ligand
(1)
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NO Synthase Related Products (1014)
Related Products (1014)
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Antibodies (6)
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NO Synthase Isoform Comparison
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Pelubiprofen (Standard)
0 ImagesCat. No.: HY-12383RCAS No.: 69956-77-0Pelubiprofen (Standard) is the analytical standard of Pelubiprofen. This product is intended for research and analytical applications. Pelubiprofen is an orally active anti-inflammatory agent that inhibits COX enzyme activity (with IC50 values of 10.66 and 2.88 μM for COX-1 and COX-2, respectively). Pelubiprofen has significant anti-inflammatory and analgesic effects.
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(2R)-6-Methoxynaringenin
0 ImagesCat. No.: HY-N2715ACAS No.: 1212075-61-0(2R)-6-Methoxynaringenin is the R isomer of 6-Methoxynaringenin (HY-N2715). 6-Methoxynaringenin is a flavonoid, that inhibits NO production with an IC50 of 25.8 μM.
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Rosuvastatin lactone-d6
0 ImagesCat. No.: HY-138166SRosuvastatin lactone-d6 is the deuterium labeled Rosuvastatin lactone. Rosuvastatin lactone is a metabolite of Rosuvastatin (HY-17504A), a statin lipid-lowering agent and HMG-CoA inhibitor. Rosuvastatin lactone exhibits endothelium-independent and HMG-CoA reductase-independent vasorelaxant activity in rat aortic rings, and its vasorelaxant effect is jointly mediated by NO produced by inducible nitric oxide synthase (iNOS) located in vascular smooth muscle and activation of potassium channels. Rosuvastatin lactone itself has no lipid-lowering effect.
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Alaternin
0 ImagesCat. No.: HY-121174CAS No.: 39723-40-5Synonyms: CatharticinAlaternin (Catharticin) is an anthraquinone compound with antioxidant and hepatoprotective activities. Alaternin has an inhibitory activity against hydroxyl radicals generated in a cell-free chemical system (FeSO4/H2O2) with an IC50 value of 3.05 μM. Alaternin exhibits hepatoprotective activity against Tacrine (HY-111338)-induced toxicity in human hepatic HepG2 cells with an EC50 value of 4.02 μM.
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N-cis-Feruloyl tyramine
0 ImagesSynonyms: cis-N-(4-Hydroxyphenethyl) ferulamide; cis-N-FeruloyltyramineN-cis-Feruloyl tyramine (cis-N-(4-Hydroxyphenethyl) ferulamide) is a natural phenolic compound, exhibits modest inhibitory activity on LPS-activated NO production in RAW 264.7 cells.
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nNOS-IN-7
0 ImagesCat. No.: HY-120340CAS No.: 1895092-16-6
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Mbarraxanthone
0 ImagesCat. No.: HY-N22069CAS No.: 14211-38-2Synonyms: 1,3,7-Trihydroxy-4-prenylxanthoneMbarraxanthone (1,3,7-Trihydroxy-4-prenylxanthone) is a prenylated trioxygenated xanthone. Mbarraxanthone exhibits inhibitory activity against Gram-positive and Gram-negative bacteria, and inhibits lipopolysaccharide-induced nitric oxide (NO) production in macrophages. Mbarraxanthone can be used in research on bacterial infections.
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Esonarimod (Standard)
0 ImagesSynonyms: KE-298 (Standard)Esonarimod (Standard) is the analytical standard of Esonarimod. This product is intended for research and analytical applications. Esonarimod (KE-298) is an antirheumatic agent.
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Aminoguanidine hydrochloride (Standard)
0 ImagesSynonyms: Pimagedine hydrochloride (Standard); GER-11 (Standard); Aminoguanidinium chloride (Standard)Aminoguanidine (hydrochloride) (Standard) is the analytical standard of Aminoguanidine (hydrochloride). This product is intended for research and analytical applications. Aminoguanidine hydrochloride (Pimagedine hydrochloride) is an inhibitor of diamine oxidase and nitric oxide synthase. Aminoguanidine hydrochloride has a dose-dependent inhibitory effect on apoptosis induced by Doxorubicin (HY-15142). Aminoguanidine hydrochloride has antioxidant properties. Aminoguanidine hydrochloride can be used in diabetic nephropathy research.
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Amcinonide (Standard)
0 ImagesCat. No.: HY-B1197RCAS No.: 51022-69-6Synonyms: CL-34699 (Standard)Amcinonide (Standard) is the analytical standard of Amcinonide. This product is intended for research and analytical applications. Amcinonide is an inhibitor of NO release (IC50 = 3.38 nM). Amcinonide inhibits NNC-induced expression of the proinflammatory genes iNOS, TNF-α, and IL-1β in glial cells. Amcinonide reduces the numbers of T6+/Ia+ cells with a concomitant increase in T6+/Ia- cells. Amcinonide induces a selective reduction in expression of Ia antigens. Amcinonide can also be studied in research for eczematous dermatitis.
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NCX1022
0 ImagesCat. No.: HY-U00187CAS No.: 571186-50-0NCX1022 is an NO-releasing derivative of Hydrocortisone, which is the most widely used anti-inflammatory agent for the treatment of skin inflammation.
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TP508
0 ImagesCat. No.: HY-P0316CAS No.: 121341-81-9TP508 is a 23-amino acid nonproteolytic thrombin peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 activates endothelial NO synthase (eNOS) and stimulates production of NO in human endothelial cells. TP508 activates endothelial cells and stem cells to revascularize and regenerate tissues.
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Anti-inflammatory agent 1
0 ImagesCat. No.: HY-U00273CAS No.: 1096621-42-9Anti-inflammatory agent 1 is an anti-inflammatory agent extracted from patent WO 2009003229 A1, example 36.
