NO Synthase
Nitric oxide synthases; NOS
Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO synthases catalyze the oxidation of L-arginine to NO and L-citrulline. Mammals contain three NOS isoforms: neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS). NO produced from these different NOS isoforms is involved in a wide range of physiologic functions in the nervous, immune, and cardiovascular systems. Unregulated NO production can lead to pathologic conditions such as stroke, inflammation, and hypertension. Therefore, the control of NOS activity by isoform selective NOS inhibitors has great potential for therapeutic treatments of NO-related diseases.
NO Synthase アイソフォーム特異的製品
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NO Synthase Inhibitors
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NO Synthase Agonists
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NO Synthase Antagonists
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NO Synthase Activators
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NO Synthase Modulators
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NO Synthase MDM2 Inhibitor
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NO Synthase Inducers
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NO Synthase Controls
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NO Synthase Substrates
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NO Synthase Ligand
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NO Synthase 関連製品 (1003)
関連製品 (1003)
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抗体 (6)
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NO Synthase Isoform Comparison
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Rubranol
0 Images製品番号: HY-N1330CAS 番号: 211126-61-3Rubranol is an inhibitor of NO Synthase. Rubranol inhibits LPS-induced NO production in activated macrophages with 74% inhibition.
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trans-Isoferulic acid (Standard)
0 Images別名: trans-3-Hydroxy-4-methoxycinnamic acid (Standard)trans-Isoferulic acid (Standard) is the analytical standard of trans-Isoferulic acid. This product is intended for research and analytical applications. trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity.trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1).
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α-Humulene (Standard)
0 Imagesα-Humulene (Standard) is the analytical standard of α-Humulene. This product is intended for research and analytical applications. α-Humulene is a main constituent of Tanacetum vulgare L. (Asteraceae) essential oil with anti-inflammation (IC50=15±2 μg/mL). α-Humulene inhibits COX-2 and iNOS expression.
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Quinocetone (Standard)
0 Images製品番号: HY-123581RCAS 番号: 81810-66-4Quinocetone (Standard) is the analytical standard of Quinocetone (HY-123581). This product is used for research and analytical purposes. Quinocetone is an orally active animal feed additive used to increase the meat production of livestock and poultry. Quinocetone exhibits antibacterial activity against a variety of pathogenic microorganisms. Quinocetone exhibits tissue-specific (liver, lymphocyte) toxicity. Quinocetone induces autophagy in cells through the ATF6/DAPK1 pathway. Quinocetone activates the NF-κB and iNOS pathways, leading to cell apoptosis, hepatocyte vacuolar degeneration and fibrosis. Quinocetone can inhibit Nrf2/HO-1 and induce the generation of reactive oxygen species (ROS), leading to oxidative stress and DNA damage.
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3β,15α-Dihydroxy-7,11,23-trioxo-lanost-8-dien-26-oic acid
0 Images製品番号: HY-N13706CAS 番号: 117354-72-03β,15α-Dihydroxy-7,11,23-trioxo-lanost-8-dien-26-oic acid is a triterpene compound that can be found in Ganoderma lucidum, and it inhibits nitric oxide (NO) production in BV-2 microglial cells induced by lipopolysaccharide (LPS, HY-D1056), with an IC50 of 6.50 μM, making it a potential candidate for anti-inflammatory research.
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Artocarpesin
0 ImagesArtocarpesin is a flavonoid compound. Artocarpesin has inhibitory effects on methicillin-resistant Staphylococcus aureus (MRSA). Artocarpesin inhibits the production of NO, PGE2 and ROS by inhibiting COX-2 and iNOS expression, and plays an anti-inflammatory role. In addition, Artocarpesin inhibits platelet aggregation by inhibiting cyclic nucleotides and MAPKs, which can be used in the study of cardiovascular diseases.
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1-O-Caffeoylglycerol
0 Images製品番号: HY-N16632CAS 番号: 123134-23-61-O-Caffeoylglycerol is a compound with anti-inflammatory activity found in Sorghum bicolor. 1-O-Caffeoylglycerol significantly inhibits LPS (HY-D1056) induced NO production (IC50 = 18.5 μM) and dose dependently inhibits iNOS protein expression. 1-O-Caffeoylglycerol can be used for research on inflammatory conditions.
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GYY4137 (Standard)
0 Images製品番号: HY-107632RCAS 番号: 106740-09-4GYY4137 (Standard) is the analytical standard of GYY4137 (HY-107632). This product is intended for research and analytical applications. GY4137 is a sustained-release H2S donor possessing vasodilatory, antihypertensive, and anti-inflammatory activities. GY4137 can inhibit cell growth, induce apoptosis, and cause cell cycle arrest by blocKing the STAT3 pathway, demonstrating potent anticancer activity.
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Cinnamyl Alcohol-d9
0 Images製品番号: HY-Y0078S1CAS 番号: 3028869-57-7
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Valeriandoid B
0 Images製品番号: HY-133198CAS 番号: 1380399-57-4Valeriandoid B is a Iridoids product that can be isolated from the herbs of Valeriana jatamansi.
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H-D-Tpi-OH
0 Images製品番号: HY-W269285CAS 番号: 72002-54-1別名: D-1,2,3,4-Tetrahydronorharman-3-carboxylic acidH-D-Tpi-OH (D-1,2,3,4-Tetrahydronorharman-3-carboxylic acid) is a tetrahydro-β-carboline derivative. H-D-Tpi-OH only slightly upregulates QR1, mildly inhibits the aromatase and NO synthesis pathways, and shows no significant in vitro anti-breast tumor proliferation activity. H-D-Tpi-OH can be used in cancer-related research.
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Apiin (Standard)
0 Images製品番号: HY-N0577RCAS 番号: 26544-34-3別名: Apigenin 7-O-apiosylglucoside (Standard); Apigenin 7-(2-O-apiosylglucoside) (Standard)Apiin (Standard) is the analytical standard of Apiin. This product is intended for research and analytical applications. Apiin, a major constituent of Apium graveolens leaves with anti-inflammatory properties. Apiin shows significant inhibitory activity on nitrite (NO) production (IC50 = 0.08 mg/mL) in-vitro and iNOS expression (IC50 = 0.049 mg/ mL) in LPS-activated J774.A1 cells.
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Sulpho NONOate
0 Images製品番号: HY-155224CAS 番号: 61142-90-3別名: Sulfi/NOSulpho NONOate (Sulfi/NO) does not produce NO at physiological pH. Sulpho NONOate can be used in the experiments about other NO-donor regents as a negative control.
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L-Arginine-15N4,d7 hydrochloride
0 Images製品番号: HY-N0455AS9別名: (S)-(+)-Arginine-15N4,d7 hydrochlorideL-Arginine-15N4,d7 (hydrochloride) is the deuterium and 15N-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
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Aminopicoline (Standard)
0 Images別名: Ascensil (Standard); 2-Amino-4-methylpyridine (Standard)Aminopicoline (Standard) is the analytical standard of Aminopicoline. Aminopicoline (Ascensil) is a potent and non-selective inhibitor of nitric oxide synthase (NOS) isoenzymes (iNOS, nNOS, eNOS). Aminopicoline competes with arginine at the substrate-binding site of nitric oxide synthase, reduces cellular nitric oxide production, inhibits the elevation of plasma nitrate, increases mean arterial pressure at high doses, and also serves as a basis for radiolabeled ligands to localize nitric oxide synthase binding sites. Aminopicoline can be used in the research of diseases associated with septic shock, joint inflammation, intestinal inflammation, and CNS inflammation。
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Roburic acid (Standard)
0 ImagesRoburic acid (Standard) is the analytical standard of Roburic acid. This product is intended for research and analytical applications. Roburic acid acts as an anti-inflammatory, anti-tumor and osteoclastogenesis inhibitor, with a Ki of 7.066 μM against human TNF, an IC50 of 9 μM against human COX-2, and an IC50 of 5 μM against ovine COX-1. Roburic acid reduces the production of inflammatory mediators such as NO and IL-6 in macrophages by inhibiting the NF-κB and MAPK (p38/JNK) pathways. By competitively inhibiting the TNF-TNF-R1 interaction, Roburic acid blocks the downstream NF-κB signaling pathway, thereby inducing cell cycle arrest and apoptosis in cancer cells. Roburic acid specifically inhibits osteoclastogenesis and bone resorption by suppressing the RANKL/TRAF6/NF-κB/NFATc1 axis. Roburic acid can be used in research related to osteolytic diseases such as osteoporosis, colorectal cancer and inflammatory diseases.
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CI-1018
0 Images製品番号: HY-19299CAS 番号: 245329-99-1CI-1018 is an orally active selective PDE-4 inhibitor, with IC50 values of 1.1 μM, 35.8 μM, and 73.4 μM against hPDE-4, canine PDE-4, and guinea pig PDE-4, respectively. CI-1018 induces iNOS expression and Apoptosis. CI-1018 induces vascular injury, medial necrosis, hemorrhage, edema, thymic atrophy, ketonuria, and weight loss. CI-1018 can be used in research related to asthma, vasculitis, and mesenteric vasculitis/arteriopathy.
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Haloperidol decanoate (Standard)
0 Images製品番号: HY-107969RCAS 番号: 74050-97-8Haloperidol decanoate (Standard) is the analytical standard of Haloperidol decanoate. This product is intended for research and analytical applications. Haloperidol decanoate is a depot preparation of haloperidol, a commonly used butyrophenone derivative with antipsychotic activity. Haloperidol decanoate can increase the striatal D2 receptor in rat. Haloperidol decanoate can improve conditions of psychoses (mainly schizophrenia). Haloperidol decanoate can lead to increased accumulation of the dopamine metabolites homo-vanillic acid. Haloperidol decanoate can reduce intestinal transport, increase gastric emptying and reduce acid output in rat model.
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Gluconate Calcium (Standard)
0 Images別名: Calcium D-gluconate (Standard); Gluconic acid hemicalcium salt (Standard)Gluconate Calcium (Standard) (Calcium D-gluconate (Standard)) is the analytical standard of Gluconate Calcium (HY-B1092). This product is intended for research and analytical applications. Gluconate (D-Gluconic acid) Calcium is an orally active glucose derivative. Gluconate Calcium reduces nitric oxide and inflammatory cytokines (IL-1β and IL-6). Gluconate Calcium inhibits ERK phosphorylation. Gluconate Calcium has antioxidant and antiplatelet activation activities. Gluconate Calcium has antitumor activity against colorectal cancer. Gluconate Calcium improves osteoarthritis, intestinal damage and acute lung injury.
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Irisflorentin (Standard)
0 Images製品番号: HY-N0268RCAS 番号: 41743-73-1Irisflorentin (Standard) is the analytical standard of Irisflorentin. This product is intended for research and analytical applications. Irisflorentin, a naturally occurring isoflavone, is an abundant active constituent in Belamcanda chinensis. Irisflorentin markedly reduces the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO. Anti-inflammatory activity.
