Opioid Receptor
Opioid receptors are a group of G protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. Opioid receptors are distributed widely in the brain, and are found in the spinal cord and digestive tract. Opioid receptors are molecules, or sites, within the body that are activated by opioid substances. Opioid receptors inhibit the transmission of impulse in excitatory pathways within the human body system. These pathways include the serotonin, catecholamine, and substance P pathways, which are all implicated in pain perception and feelings of well-being. Opioid receptors are further subclassified into mu, delta, and kappa receptors. All the classes, while exhibiting differing modes of action, share some basic similarities. They all are driven by the potassium pump mechanism, which is found on the plasma membrane of the majority of cells.
Opioid Receptor Isoform Specific Products
All Product Categories
-
Opioid Receptor Inhibitors
(23)
View all products
-
Opioid Receptor Agonists
(300)
View all products
-
Opioid Receptor Antagonists
(130)
View all products
-
Opioid Receptor Activators
(32)
View all products
-
Opioid Receptor Modulators
(28)
View all products
-
Opioid Receptor Controls
(7)
View all products
-
Opioid Receptor Ligands
(9)
View all products
-
Opioid Receptor Related Products (616)
Related Products (616)
-
Antibodies (3)
-
Opioid Receptor Isoform Comparison
-
BU72
0 ImagesCat. No.: HY-171758CAS No.: 173265-76-4BU72 is a highly potent and long-acting agonist of μ and κ opioid receptors, and also has a partial agonist effect on δ opioid receptors (EC50 values are 0.054, 0.033, and 0.58 nM, respectively). BU72 has a strong and long-lasting analgesic effect, which is mainly mediated by μ opioid receptors. BU72 has a long-lasting activity and can partially reverse the analgesic effect of morphine. BU72 can be used in the study of opioid dependence.
-
(+)-U-50488
0 ImagesCat. No.: HY-130696CAS No.: 67198-17-8Synonyms: (+)-Trans-(1R,2R)-U-50488(+)-U-50488 ((+)-Trans-(1R,2R)-U-50488) is a less active κ opioid receptor (KOR) agonist than the enantiomer of (-)-Trans-(1S,2S)-U-50488 (HY-15997).
-
Acetalin-1
0 ImagesCat. No.: HY-P10175CAS No.: 152274-67-4Acetalin-1 (Ac-RFMWMK-NH2), a hexapeptide, is a μ opioid receptor antagonist with high affinity for μ and κ3 opioid receptor, weak affinity for κ1 receptors and no affinity for κ2 receptors.
-
(+)-U-50488 hydrochloride
0 ImagesCat. No.: HY-15997ACAS No.: 114528-81-3Synonyms: (+)-Trans-(1R,2R)-U-50488 hydrochloride(+)-U-50488 (hydrochloride) (+)-Trans-(1R,2R)-U-50488 hydrochloride) is a less active κ opioid receptor (KOR) agonist than the enantiomer of (-)-Trans-(1S,2S)-U-50488 (HY-15997).
-
β-Endorphin, equine
0 ImagesCat. No.: HY-P1866CAS No.: 79495-86-6β-Endorphin, equine is an endogenous opioid peptide, which binds at high affinity to both μ/δ opioid receptors. Analgesic properties.
-
CTOP
0 ImagesCat. No.: HY-P1329CAS No.: 103429-31-8CTOP is a potent and highly selective μ-opioid receptor antagonist. CTOP antagonizes the acute morphine-induced analgesic effect and hypermotility. CTOP enhances extracellular dopamine levels in the nucleus accumbens. CTOP dose-dependently enhances locomotor activity.
-
Deltorphin I TFA
0 ImagesCat. No.: HY-P1336ACAS No.: 2952824-50-7Synonyms: Deltorphin 1 TFA; Deltorphin C TFA; [D-Ala2] Deltorphin I TFADeltorphin I TFA (Deltorphin 1 TFA; Deltorphin C TFA; [D-Ala2] Deltorphin I TFA) is a high-affinity, selective δ-opioid receptor agonist that targets the δ1 and δ2 opioid receptor subtypes. Deltorphin I TFA produces analgesic effects in the rat spinal cord. Deltorphin I TFA increases the pain threshold in rats. Deltorphin I TFA can be used in studies related to nociception (acute pain).
-
DP32
0 ImagesCat. No.: HY-P10394CAS No.: 2376306-14-6DP32 is a bifunctional compound that contains an opioid receptor (MOP) agonist and a neuropeptide FF receptor (NPFFR) antagonist. DP32 can be used in analgesia-related research.
-
EST73502
0 ImagesCat. No.: HY-134189CAS No.: 1838622-25-5EST73502 is a selective, orally active and blood-brain barrier (BBB) penetrant dual μ-opioid receptor (MOR) agonist and σ1 receptor (σ1R) antagonist, with Kis of 64 nM and 118 nM for MOR and σ1R, respectively. EST73502 has antinociceptive activity.
-
Axelopran
0 ImagesCat. No.: HY-16765CAS No.: 949904-48-7Synonyms: TD-1211Axelopran (TD-1211) is an opioid receptor antagonist with pKi values of 9.8, 8.8 and 9.9 for human recombinant μ and δ receptors and guinea pig κ receptor, respectively.
-
Opioid receptor antagonist 1
0 ImagesCat. No.: HY-170654CAS No.: 1559075-15-8Opioid receptor antagonist 1 (Compound 10) is an Orvinol (HY-D0168)-based opioid receptor antagonist. Opioid receptor antagonist 1 has antagonistic activity to the analgesic properties of Morphine.
-
Naltriben
0 ImagesCat. No.: HY-133717CAS No.: 111555-58-9Naltriben is a selective δ2-opioid receptor antagonist and TRPM7 activator. Naltriben enhances glioblastoma cell migration and invasion. Naltriben can be used in research into neurological diseases and cancer.
-
Trimebutine-d3 hydrochloride
0 ImagesCat. No.: HY-B0380S2Trimebutine-d3 hydrochloride is deuterium labeled Trimebutine hydrochloride. Trimebutine hydrochloride is a multi-target inhibitor and opioid receptor agonist with antimuscarinic activity. Trimebutine hydrochloride inhibits L-type Ca2+ channels and large-conductance calcium-activated potassium channels (BKCa channels), thereby inhibiting extracellular calcium influx and potassium ion efflux. Trimebutine hydrochloride also targets Toll-like receptors, inhibits Toll-like receptor 2/4/7/8/9 signals, and inhibits LPS-induced IRAK1 activation, as well as ERK1/2, JNK and NF-κB activation, thereby exerting anti-inflammatory effects. Trimebutine hydrochloride also induces tumor cell apoptosis by inhibiting the AKT/ERK pathway. Trimebutine hydrochloride also inhibits excessive contraction of smooth muscle and can be used in the study of gastrointestinal disorders such as irritable bowel syndrome (IBS).
-
δ opioid receptor antagonist 1
0 ImagesCat. No.: HY-163895δ opioid receptor antagonist 1 (compound 6-Cy3) is a fluorescent antagonist probe with high selectivity for δ opioid receptor (DOR) (Ki=1.7 nM). δ opioid receptor antagonist 1 can be used to study the mechanism of pain perception.
-
Difelikefalin acetate
0 ImagesCat. No.: HY-17609CCAS No.: 2803411-76-7Synonyms: CR-845 acetate; FE-202845 acetateDifelikefalin acetate (CR-845 acetate; FE-202845 acetate) is an orally active peripherally acting kappa opioid receptor agonist. Difelikefalin acetate reduces acute kidney injury, decreases oliguria, maintains urine flow, inhibits cytokine expression, and improves survival in endotoxemia after ischemia/reperfusion. Difelikefalin acetate suppresses pruritus signals and exhibits neuromodulatory antipruritic activity. Difelikefalin acetate can be used in research related to acute kidney injury, chronic kidney disease-associated pruritus, and atopic dermatitis.
-
Ondelopran
0 ImagesCat. No.: HY-107121CAS No.: 676501-25-0Synonyms: LY 2196044Ondelopran (LY 2196044) is a non-selective opioid receptor antagonist. Ondelopran inhibits the release of dopamine in the nucleus accumbens induced by alcohol, reduces the rewarding effect of alcohol consumption, and lowers the craving. Ondelopran can be used for alcohol use disorder (AUD).
-
(Rac)-SNC80
0 ImagesCat. No.: HY-101202ACAS No.: 1217643-87-2Synonyms: (Rac)-NIH 10815(Rac)-SNC80 is a racemate of SNC80 (HY-101202). SNC80 (NIH 10815) is a potent, highly selective and non-peptide δ-opioid receptor agonist with a Ki of 1.78 nM and an IC50 of 2.73 nM. SNC80 shows antinociceptive, antihyperalgesic and antidepressant‐like effects. SNC80 has the potential for multiple headache disorders treatment.
-
β-Chlornaltrexamine dihydrochloride
0 ImagesCat. No.: HY-141468CAS No.: 67025-98-3Synonyms: β-CNA dihydrochlorideβ-Chlornaltrexamine dihydrochloride (β-CNA dihydrochloride) is a potent long-term opioid receptor blocker. β-Chlornaltrexamine dihydrochloride can effectively block the inhibitory effect of κ opioid receptor agonists on dopamine release. β-Chlornaltrexamine dihydrochloride can be used to study the mechanism of pain perception.
-
Opioid receptor agonist 1
0 ImagesCat. No.: HY-173030Opioid receptor agonist 1 (Compound 2638-28) is the orally active agonist for opioid receptor that exhibits good affinity to MOR, DOR and KOR with Ki of 5, 24 and 212 nM, respectively. Opioid receptor agonist 1 exhibits analgesic activity in mouse warm water tail flick models and acetic acid writhing models.
