Opioid Receptor
Opioid receptors are a group of G protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. Opioid receptors are distributed widely in the brain, and are found in the spinal cord and digestive tract. Opioid receptors are molecules, or sites, within the body that are activated by opioid substances. Opioid receptors inhibit the transmission of impulse in excitatory pathways within the human body system. These pathways include the serotonin, catecholamine, and substance P pathways, which are all implicated in pain perception and feelings of well-being. Opioid receptors are further subclassified into mu, delta, and kappa receptors. All the classes, while exhibiting differing modes of action, share some basic similarities. They all are driven by the potassium pump mechanism, which is found on the plasma membrane of the majority of cells.
Opioid Receptor Isoform Specific Products
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Opioid Receptor Inhibitors
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Opioid Receptor Agonists
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Opioid Receptor Antagonists
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Opioid Receptor Activators
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Opioid Receptor Modulators
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Opioid Receptor Controls
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Opioid Receptor Ligands
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Opioid Receptor Related Products (617)
Related Products (617)
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Antibodies (3)
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Opioid Receptor Isoform Comparison
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Opioid receptor agonist 1
0 ImagesCat. No.: HY-173030Opioid receptor agonist 1 (Compound 2638-28) is the orally active agonist for opioid receptor that exhibits good affinity to MOR, DOR and KOR with Ki of 5, 24 and 212 nM, respectively. Opioid receptor agonist 1 exhibits analgesic activity in mouse warm water tail flick models and acetic acid writhing models.
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Valorphin
0 ImagesCat. No.: HY-P1599CAS No.: 144313-54-2Valorphin is an endogenous hemoglobin β-chain (33-39) fragment with opioid analgesic activity, binds to rat mu-opioid receptor, with an IC50 of 14 nM; Valorphin also shows anti-tumor activity.
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Sameridine hydrochloride
0 ImagesCat. No.: HY-105525ACAS No.: 136483-84-6Synonyms: NIH 10908Sameridine hydrochloride is a local anesthetic and local analgesic.
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BU09059
0 ImagesCat. No.: HY-119733CAS No.: 1541206-05-6BU09059 is a potent and selective Kappa-opioid receptor antagonist with a pA2 of 8.62. BU09059 has nanomolar affinity for the κ-receptor, with 15-fold and 616-fold selectivity over μ- and δ-receptors, respectively. BU09059 significantly blocks U50488 (HY-15997B)-induced antinociception.
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RO-76
0 ImagesCat. No.: HY-162728RO-76 is a mu opioid receptor (μOR) selective partial agonist. RO-76 binds to μOR-G-protein complex with an EC50 value of 454 nM. RO-76 reduces β-Arrestin-1/2 recruitment. RO-76 shows antinociception activity.
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MOR agonist-2
0 ImagesCat. No.: HY-155706CAS No.: 2833692-02-5MOR agonist-2 (compound 46) is a antagonist of D3R and agonist of MOR (Ki: 7.26 nM and 564 nM, respectively). MOR agonist-2 has the potential to produce analgesic effects through MOR partial agonism. MOR agonist-2 reduces opioid-misuse liability via D3R antagonism.
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α-Endorphin (human, mouse, rat, porcine, bovine, ovine)
0 Imagesα-Endorphin (human, mouse, rat, porcine, bovine, ovine) is a neuropeptide, that acts on the central nervous system (CNS) and peripheral nervous system (PNS). α-Endorphin (human, mouse, rat, porcine, bovine, ovine) binds μ-opioid receptor, and exhibits analgesic efficacy. α-Endorphin (human, mouse, rat, porcine, bovine, ovine) regulates sexual behaviors and pleasure felling.
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ID110460001
0 ImagesCat. No.: HY-W399025CAS No.: 1110883-26-5ID110460001 is a full agonist of μ-opioid receptor and an agonist of δ-opioid receptor. ID110460001 exhibits high intrinsic efficacy for G protein pathway activation of μ-opioid receptor, and this property is not affected by the reduction in receptor quantity. ID110460001 acts only as a very weak partial agonist in the β-arrestin-2 pathway of both receptors, and binds to μ-opioid receptor via a specific mode. The efficacy of ID110460001 in the G protein pathway of δ-opioid receptor is sensitive to changes in receptor quantity. ID110460001 can be used in pain-related research.
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β-Endorphin (6-31), human
0 ImagesCat. No.: HY-P3517CAS No.: 77761-27-4Synonyms: β-EP (6-31), humanβ-Endorphin, an endogenous opioid neuropeptide, is an opioid receptor agonist. β-Endorphin binds preferentially to μ-opioid receptors and is produced in certain neurons of the central and peripheral nervous system and is one of three endorphins produced in humans. β-Endorphin can be used to reduce stress and maintain homeostasis in the body and is involved in neurological pain perception regulation.
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TIPP
0 ImagesCat. No.: HY-120277CAS No.: 146369-65-5Synonyms: H-Tyr-Tic-Phe-Phe-OHTIPP is a potent and selective δ-opioid antagonist with a Ki value of 1.22 nM.
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Dermorphin Analog
0 ImagesCat. No.: HY-P1577CAS No.: 115814-08-9Dermorphin Analog is an analog of Dermorphin. Dermorphin is a natural heptapeptide μ-opioid receptor agonist found in amphibian skin.
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Trimebutine-d5 fumarate
0 ImagesCat. No.: HY-B0380S1CAS No.: 2747915-18-8Trimebutine-d5 fumarate is deuterium labeled Trimebutine fumarate. Trimebutine fumarate is a multi-target inhibitor and opioid receptor agonist with antimuscarinic activity. Trimebutine fumarate inhibits L-type Ca2+ channels and large-conductance calcium-activated potassium channels (BKCa channels), thereby inhibiting extracellular calcium influx and potassium ion efflux. Trimebutine fumarate also targets Toll-like receptors, inhibits Toll-like receptor 2/4/7/8/9 signals, and inhibits LPS-induced IRAK1 activation, as well as ERK1/2, JNK and NF-κB activation, thereby exerting anti-inflammatory effects. Trimebutine fumarate also induces tumor cell apoptosis by inhibiting the AKT/ERK pathway. Trimebutine fumarate also inhibits excessive contraction of smooth muscle and can be used in the study of gastrointestinal disorders such as irritable bowel syndrome (IBS).
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β-Lipotropin (60-65)
0 ImagesCat. No.: HY-P3550CAS No.: 60117-19-3Synonyms: β-LPH (60-65); [Arg0] Met-Enkephalinβ-Lipotropin (60-65) (β-LPH (60-65)), an opioid peptide, is a potent opioid agonist.
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Dynorphin A (1-13) amide
0 ImagesCat. No.: HY-P5061CAS No.: 79515-34-7Dynorphin A (1-13) amide is an endogenous opioid peptide that antagonizes morphine-induced analgesia.
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DSLET
0 ImagesCat. No.: HY-P1332CAS No.: 75644-90-5Synonyms: [D-Ser2, Leu5, Thr6]-enkephalinDSLET ([D-Ser2, Leu5, Thr6]-enkephalin) is a highly specific agonist of the δ-receptor. DSLET is an enkephalin-related peptide selectively bound to the δ opioid receptor.
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MOR agonist-5
0 ImagesCat. No.: HY-179705CAS No.: 3085132-31-3MOR agonist-5 is a selective and potent mu-opioid receptor (MOR) agonist with an EC50 of 0.25 nM. MOR agonist-5 shows an EC50 of 10 nM for DOR and >10000 nM for KOR and NOR. MOR agonist-5 exerts significant antinociceptive activity. MOR agonist-5 can be used for the research of pain.
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β-Casomorphin, human
0 ImagesCat. No.: HY-P1481CAS No.: 102029-74-3Synonyms: Human β-casomorphin 7is an opioid peptide, acts as an agonist of opioid receptor.
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Azo-enkephalin
0 ImagesCat. No.: HY-129237CAS No.: 76995-89-6Azo-enkephalin is an endorphin analog with significant analgesic activity. Azo-enkephalin can be used in the development of opioid analgesics.
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Ketazocine
0 ImagesCat. No.: HY-122169CAS No.: 36292-69-0Synonyms: KetocyclazocineKetazocine (Ketocyclazocine) is a selective κ-opioid receptor (KOR) agonist. Ketazocine is promising for research of analgesics and sedatives.
