PDGFR
Platelet-derived growth factor receptor
PDGFR (Platelet-derived growth factor receptors) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family. PDGF subunits -A and -B are important factors regulating cell proliferation, cellular differentiation, cell growth, development and many diseases including cancer. There are two forms of the PDGFR: PDGFR alpha and PDGFR beta.
PDGFR Isoform Specific Products
All Product Categories
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PDGFR Inhibitors
(276)
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PDGFR Antagonist
(1)
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PDGFR Activators
(3)
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PDGFR Modulators
(2)
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PDGFR Chemical
(1)
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PDGFR Degrader
(1)
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PDGFR Control
(1)
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PDGFR Ligands
(4)
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PDGF-R-alpha Proteins
(12)
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PDGF-R-beta Proteins
(8)
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PDGFR Proteins
(22)
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PDGFR Related Products (320)
Related Products (320)
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Recombinant Proteins (22)
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Antibodies (5)
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PDGFR Isoform Comparison
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PDGFRalpha V561D Recombinant Human Active Protein Kinase
0 ImagesCat. No.: HY-E70764PDGFRalpha is a receptor tyrosine kinases that stimulate cell survival, proliferation and motility. Upon PDGF binding, the receptor dimerizes and undergoes a conformational change, which activates the kinase domain. PDGFRalpha V561D is a mutant of PDGFRalpha. PDGFRalpha V561D Recombinant Human Active Protein Kinase is a recombinant PDGFRalpha V561D protein that can be used to study PDGFRalpha V561D-related functions.
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Xanthinol Nicotinate (Standard)
0 ImagesXanthinol Nicotinate (Standard) is the analytical standard of Xanthinol Nicotinate. This product is intended for research and analytical applications. Xanthinol Nicotinate (Xanthinol Niacinate), a vasodilator, can act directly on the smooth muscle of small arteries and capillaries. Xanthinol Nicotinate expands blood vessels, improves blood rheology and reduces peripheral vascular resistance.
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VEGFR-2-IN-89
0 ImagesCat. No.: HY-184720VEGFR-2-IN-89 is a VEGFR-2 inhibitor with an IC50 of 77 nM. VEGFR-2-IN-89 potently inhibits c-Met kinase activity with an IC50 of 0.152 μM, and also exhibits good inhibitory activity against EGFR (IC50 = 0.269 μM) and PDGFR-β kinase (IC50 = 0.301 μM). VEGFR-2-IN-89 displays anticancer activity against liver cancer. VEGFR-2-IN-89 can be used in the research of hepatocellular carcinoma.
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Antifibrotic agent 1
0 ImagesCat. No.: HY-176194Antifibrotic agent 1 is an orally active anti-idiopathic pulmonary fibrosis (IPF) agent. Antifibrotic agent 1 effectively attenuates IPF-related processes, including TGF-β induced EMT and FMT processes, as well as pro-fibrotic M2 polarization. Antifibrotic agent 1 selectively inhibits CSF-1R, PDGFR-α and Src family kinases (SFKs), while sparing VEGFRs, FGFRs and Abl to minimize off-target toxicity. Antifibrotic agent 1 has potent anti-fibrotic activity in Bleomycin (BLM) (HY-108345)-induced pulmonary fibrosis mice model.
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Pdgfra Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS10255Pdgfra Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pdgfra gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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MET/PDGFRA-IN-1
0 ImagesCat. No.: HY-149510CAS No.: 3125694-48-3MET/PDGFRA-IN-1 (compound 8c) is a MET and PDGFRA protein inhibitor (IC50: 36 μM for MET). MET/PDGFRA-IN-1 inhibits MET phosphorylation and induces cell apoptosis. MET/PDGFRA-IN-1 inhibits proliferation of MET-positive cells (IC50s: 15.3, 19.0, 22.0, 25.6, 21.0, 31.5 μM for AsPc-1, EBC-1, MKN-45, Mia-Paca-2, HT-29, K562 cells respectively).
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KIT/PDGFRA-IN-3
0 ImagesCat. No.: HY-189238KIT/PDGFRA-IN-3 is a KIT and PDGFRA mutant kinase inhibitor, with an IC50 of 9 nM against human PDGFRA. KIT/PDGFRA-IN-3 inhibits the kinase activity of KIT, exhibiting superior selectivity for mutant KIT over wild-type KIT. KIT/PDGFRA-IN-3 suppresses the kinase activity of PDGFRA and blocks downstream signaling pathways. KIT/PDGFRA-IN-3 can be used in studies of gastrointestinal stromal tumors.
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PDGFRα/FLT3-ITD-IN-2
0 ImagesCat. No.: HY-145903CAS No.: 2761259-09-8PDGFRα/FLT3-ITD-IN-2 (Compound 13d) is a potent inhibitor of PDGFRα/FLT3 with IC50s of more than 20 and 1.654 μM, respectively. PDGFRα/FLT3-ITD-IN-2 has the potential for the research of acute myeloid leukemia or chronic eosinophilic leukemia.
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IHMT-TRK-284
0 ImagesCat. No.: HY-146697CAS No.: 2416844-79-4
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Henatinib
0 ImagesCat. No.: HY-13645CAS No.: 1239269-51-2Henatinib is an orally active small-molecule multikinase inhibitor that has demonstrated broad and potent antitumor activities. Henatinib inhibits the activity of VEGFR-2, c-kit, PDGFR with IC50 values of 0.6 nM, 3.3 nM and 41.5 nM, respectively. Henatinib significantly inhibits VEGFR-2 phosphorylation and its downstream signal pathway in human umbilical vein endothelial cells (HUVECs).
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KN1022
0 ImagesCat. No.: HY-149462CAS No.: 205255-11-4KN1022 an inhibitor of phosphorylation of platelet-derived growth factor receptor (PDGFR) with IC50 of 0.24 μM.
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Pazopanib Hydrochloride (Standard)
0 ImagesSynonyms: GW786034 Hydrochloride (Standard)Pazopanib (Hydrochloride) (Standard) is the analytical standard of Pazopanib (Hydrochloride). This product is intended for research and analytical applications. Pazopanib Hydrochloride (GW786034 Hydrochloride) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with an IC50 of 10, 30, 47, 84, 74, 140 and 146 nM, respectively.
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Regorafenib-13C,d3
0 ImagesCat. No.: HY-10331S1Synonyms: BAY 73-4506-13C,d3
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Biotin-PDGFRβ Recombinant Human Active Protein Kinase
0 ImagesCat. No.: HY-E70803PDGF-BB/PDGFRβ signaling plays an important role during vascularization by mediating pericyte recruitment to the vasculature, promoting the integrity and function of vessels. Biotin-PDGFRβ Recombinant Human Active Protein Kinase is a recombinant PDGFRβ protein that can be used to study PDGFRβ-related functions, and is biotinylated.
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Tyrphostin A9 (Standard)
0 ImagesSynonyms: Tyrphostin 9 (Standard); Malonoben (Standard)Tyrphostin A9 (Standard) is the analytical standard of Tyrphostin A9. This product is intended for research and analytical applications. Tyrphostin A9, a PDGFR inhibitor, is a potent inducer of mitochondrial fission. Tyrphostin A9 emerged as the most potent and selective of 51 tyrosine kinase inhibitors tested against the TNF-induced respiratory burst. Tyrphostin A9 has anti-influenza virus activities.
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Cediranib maleate (Standard)
0 ImagesSynonyms: AZD-2171 maleate (Standard)Cediranib (maleate) (Standard) is the analytical standard of Cediranib (maleate). This product is intended for research and analytical applications. Cediranib maleate (AZD-2171 maleate) is a highly potent, orally available VEGFR inhibitor with IC50s of <1, <3, 5, 5, 36, 2 nM for Flt1, KDR, Flt4, PDGFRα, PDGFRβ, c-Kit, respectively.
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Masitinib mesylate (Standard)
0 ImagesSynonyms: AB-1010 mesylate (Standard)Masitinib (mesylate) (Standard) is the analytical standard of Masitinib (mesylate). This product is intended for research and analytical applications. Masitinib mesylate (AB-1010 mesylate) is a potent, orally bioavailable, and selective inhibitor of c-Kit (IC50=200 nM for human recombinant c-Kit). It also inhibits PDGFRα/β (IC50s=540/800 nM), Lyn (IC50= 510 nM for LynB), Lck, and, to a lesser extent, FGFR3 and FAK. Masitinib mesylate (AB-1010 mesylate) has anti-proliferative, pro-apoptotic activity and low toxicity.
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Toceranib phosphate (Standard)
0 ImagesCat. No.: HY-10330ARCAS No.: 874819-74-6Synonyms: SU11654 phosphate (Standard); PHA 291639E phosphate (Standard)Toceranib phosphate (Standard) is the analytical standard of Toceranib phosphate (HY-10330A). This product is intended for research and analytical applications. Toceranib phosphate (SU11654 phosphate) is an orally active receptor tyrosine kinase (RTK) inhibitor, and it potently inhibits PDGFR, VEGFR, and Kit with Kis of 5 and 6 nM for PDGFRβ and Flk-1/KDR, respectively. Toceranib phosphate (SU11654 phosphate) has antitumor and antiangiogenic activity, and used in the treatment of canine mast cell tumors .
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RPR-101511
0 ImagesCat. No.: HY-172228CAS No.: 146535-06-0RPR-101511 is a 3-substituted quinoline derivative. RPR-101511 is a PDGF receptor tyrosine kinase inhibitor (IC50: 0.001-0.02 μM).
