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Art. -Nr.: HY-184720

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VEGFR-2-IN-89

VEGFR-2-IN-89 is a VEGFR-2 inhibitor with an IC₅₀ of 77 nM. VEGFR-2-IN-89 potently inhibits c-Met kinase activity with an IC₅₀ of 0.152 μM, and also exhibits good inhibitory activity against EGFR (IC₅₀ = 0.269 μM) and PDGFR-β kinase (IC₅₀ = 0.301 μM). VEGFR-2-IN-89 displays anticancer activity against liver cancer. VEGFR-2-IN-89 can be used in the research of hepatocellular carcinoma.

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Formel: C₂₁H₁₇N₅O₃
Molecular Weight:387.39

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

VEGFR-2-IN-89 Chemical Structure

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
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Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

VEGFR2

77 nM (IC₅₀)

c-Met

0.152 μM (IC₅₀)

EGFR

0.269 μM (IC₅₀)

PDGFR-β

0.301 μM (IC₅₀)

Alle VEGFR Isoform-spezifische Produkte anzeigen :

Alle EGFR Isoform-spezifische Produkte anzeigen :

Alle PDGFR Isoform-spezifische Produkte anzeigen :

In Vitro

VEGFR-2-IN-89 (Compound 6f) potently inhibits the proliferation of HepG-2 hepatocellular carcinoma cells with an IC₅₀ of 8.32 μM; it exhibits moderate activity against another 5 cancer cell lines, shows low cytotoxicity toward WI-38 and L02 normal cells, and has a favorable selectivity index^[1].
VEGFR-2-IN-89 potently inhibits VEGFR-2 kinase activity with an IC₅₀ of 0.077 μM, exhibiting greater efficacy than Sorafenib (HY-10201)^[1].
VEGFR-2-IN-89 potently inhibits c-Met kinase activity with an IC₅₀ of 0.152 μM, and also exhibits favorable inhibitory activity against EGFR and PDGFR-β kinases^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 387.39
Formel C₂₁H₁₇N₅O₃
SMILES

O=C(N/N=C/C1=CC=C(C)O1)C2=CC=C(N/N=C3C(NC4=C\3C=CC=C4)=O)C=C2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Mansour NI, et al. New indolin-2-one and isoindoline-1,3-dione derivatives as potential anti-hepatocellular carcinoma agents targeting VEGFR-2: Synthesis, in vitro, in vivo, and in silico evaluation. Bioorganic chemistry. 2026 Jun 29;180:110187. [Content Brief]

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Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
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VEGFR-2-IN-89

Alle VEGFR Isoform-spezifische Produkte anzeigen

Alle EGFR Isoform-spezifische Produkte anzeigen

Alle PDGFR Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

VEGFR-2-IN-89 Related Classifications

HY-184720 Related Classifications