PKA
Protein kinase A
PKA (Protein kinase A) is a Ser/Thr phosphoryl transferase that transfers the γ-phosphate group of ATP to protein substrates. PKA phosphorylates more than 100 cytoplasmic and membrane associated targets. PKA mediates a myriad of cellular signaling events and its activity is tightly regulated both in space and time.
PKA is an evolutionarily conserved negative regulator of the hedgehog (Hh) signal transduction pathway. PKA is known to be required for the proteolytic processing event that generates the repressor forms of the Ci and Gli transcription factors that keep target genes off in the absence of Hh.
Alle PKA Isoform-spezifische Produkte anzeigen
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PKA Verwandte Produkte (240)
Verwandte Produkte (240)
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Antibodies (9)
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PKA Isoform Comparison
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(+)-Epiloliolide
0 ImagesArt. -Nr.: HY-N10173CAS. Nr.: 38274-00-9Synonyms: Isololiolide(+)-Epiloliolide is a megastigmane that can be isolated from Annona muricata. (+)-epiloliolide increased the nuclear localization of p53. (+)-Epiloliolide has anti-inflammatory effect through upregulating phosphorylation of the PKA/CREB pathway. (+)-Epiloliolide also effectively increases the proliferation and migration of human periodontal ligament cells by downregulating NLRP3 activated by PG-LPS.
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Fasudil Hydrochloride (Standard)
0 ImagesSynonyms: HA-1077 Hydrochloride (Standard); AT-877 Hydrochloride (Standard)Fasudil (Hydrochloride) (Standard) is the analytical standard of Fasudil (Hydrochloride). This product is intended for research and analytical applications. Fasudil (HA-1077; AT877) Hydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil Hydrochloride is also a potent Ca2+ channel antagonist and vasodilator.
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FMP-API-1
0 ImagesArt. -Nr.: HY-W288951CAS. Nr.: 16523-28-7FMP-API-1 is an A-kinase anchoring protein (AKAP)-PKA interaction inhibitor. FMP-API-1 binds to the allosteric site of PKA R subunits and increases the activity of PKA and AQP2 in PKA-knockout cell lines of renal cortical collecting ducts (mpkCCD cells). FMP-API-1 has the potential for the study of nephrogenic diabetes insipidus (NDI).
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Hu7691 free base
0 ImagesArt. -Nr.: HY-132302ACAS. Nr.: 2241232-43-7
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4-Methyloctanoic acid (Standard)
0 Images4-Methyloctanoic acid (Standard) is the analytical standard of 4-Methyloctanoic acid (HY-W010178). This product is intended for research and analytical applications. 4-Methyloctanoic acid (Standard) is an endogenous branched-chain medium-chain fatty acid and a negative regulator of the cAMP/PKA signaling pathway. 4-Methyloctanoic acid (Standard) exerts antiepileptic effects by inhibiting epileptiform discharges and terminating behavioral and electroencephalographic seizures. 4-Methyloctanoic acid (Standard) has neuroprotective effects; its polar metabolites can cross the blood-brain barrier, repair presynaptic release defects, improve motor function and alleviate neuromuscular degeneration in ALS models. 4-Methyloctanoic acid (Standard) regulates phosphatidylinositol metabolism, reduces PIP/PIP2 levels and increases inositol levels. 4-Methyloctanoic acid (Standard) can be used in studies related to epilepsy and amyotrophic lateral sclerosis.
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Fasudil hydrochloride semihydrate
0 ImagesArt. -Nr.: HY-10341BCAS. Nr.: 186694-02-0Synonyms: HA-1077 hydrochloride semihydrate; AT877 hydrochloride semihydrateFasudil (HA-1077; AT877) hydrochloride semihydrate is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil hydrochloride semihydrate is also a potent Ca2+ channel antagonist and vasodilator.
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Maxadilan
0 ImagesArt. -Nr.: HY-P3483CAS. Nr.: 135374-80-0Maxadilan is a specific irreversible PAC1 receptor agonist and a potent vasodilator peptide present in the salivary glands of sand flies. Maxadilan exhibits anti-apoptotic activity in hADSCs. Maxadilan inhibits pro-inflammatory cytokines (TNF-α) and enhances anti-inflammatory mediators (IL-10). Maxadilan can activate leukocytes and inhibit vascular permeability through PAC1 receptors. Maxadilan promotes neural differentiation of human adipose-derived stem cells. Maxadilan can be used to study endotoxin shock, atherosclerosis, and neurodegenerative diseases[1][2][3][4][5].
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Sp-cAMPS triethylamine
0 ImagesArt. -Nr.: HY-110005CAS. Nr.: 93602-66-5Sp-cAMPS triethylamine, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS triethylamine is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 µM. Sp-cAMPS triethylamine binds the PDE10 GAF domain with an EC50 of 40 μM.
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Sp-8-CPT-cAMPS
0 ImagesArt. -Nr.: HY-120994BCAS. Nr.: 129693-13-6
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Acenocoumarol-d4
0 ImagesArt. -Nr.: HY-B1014S1CAS. Nr.: 2937878-24-3Acenocoumarol-d4 is deuterium labeled Acenocoumarol (HY-B1014). Acenocoumarol is an anticoagulant that functions as a Vitamin K antagonist. Acenocoumarol inhibits MAPK/ERK/JNK signaling pathway, reduces the nuclear translocation of NF-κB p65, activates Akt/GSK3β signaling pathway. Acenocoumarol induces apoptosis in cell A549, arrests cell cycle at S phase.
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HDB-1
0 ImagesHDB-1 is a selective inhibitor of the P2Y14 receptor (P2Y14R) with an IC50 of 26 pM. HDB-1 shows no significant inhibition on P2Y1R, P2Y2R, P2Y4R, P2Y6R, and P2Y12R. HDB-1 blocks the activation of hepatic stellate cells (HSC) by inhibiting the PKA/Raf1/MEK/ERK signaling pathway mediated by P2Y14R, thereby alleviating the core pathological process of liver fibrosis. HDB-1 can be used for the study of liver fibrosis.
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DS01080522
0 ImagesArt. -Nr.: HY-150073CAS. Nr.: 2832159-84-7DS01080522 is a Protein Kinase cAMP-Activated Catalytic Subunit Alpha (PRKACA) inhibitor. DS01080522 inhibits PRKACA kinase activity and CREB phosphorylation with IC50s of 0.8 nM and 66 nM, respectively. DS01080522 can be used for the research of cancer.
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D-Mannitol, M200 (GMP Like)
0 ImagesArt. -Nr.: HY-N0378AGLCAS. Nr.: 69-65-8Synonyms: Mannitol, M200 (GMP Like); Mannite, M200 (GMP Like)D-Mannitol, M200 (GMP Like) (Mannitol, M200 (GMP Like)) is the GMP Like class D-Mannitol that can be used as pharmaceutical excipients. D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells.
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TX-1123
0 ImagesArt. -Nr.: HY-121828CAS. Nr.: 157397-06-3TX-1123 is a potent protein tyrosine kinase (PTK) inhibitor for Src, eEF2-K, and PKA, and EGFR-K/PKC. TX-1123 is a cyclo-oxygenase (COX) inhibitor with IC50 values of 1.16 μM and 15.7 μM for COX2 and COX1, respectively. TX-1123 has low mitochondrial toxicity. TX-1123 can be used in research of cancer.
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PKA RII peptide
0 ImagesArt. -Nr.: HY-P0228CAS. Nr.: 113873-67-9PKA RII peptide is a PKA substrate that, after being phosphorylated at the serine residue, can be used for the detection of calcineurin activity.
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ARN25657
0 ImagesArt. -Nr.: HY-176287ARN25657 is a dual-acting D3R/GSK-3β modulator. ARN25657 has both partial D3R agonist activity (EC50 = 15.2 nM, Ki =1.5 nM) and potent GSK-3β inhibitor activity (IC50 = 19.3 nM). ARN25657 exhibits excellent GSK-3β selectivity over FYN, PKA, and CDK5/p35. ARN25657 inhibits P-glycoprotein (P-gP)-mediated acetoxymethyl calcein efflux and improves in vitro ADME properties while maintaining a balanced dual-target profile. ARN25657 is useful for studying bipolar disorder and related neuropsychiatric disorders.
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(2S,4R)-DS89002333
0 ImagesArt. -Nr.: HY-150072A(2S,4R)-DS89002333 is the enantiomer of DS89002333 (HY-150072). DS89002333 is an orally active and potent PRKACA inhibitor, with an IC50 of 0.3 nM.
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H1-7 (histone H1 phosphorylation site), PKA Substrate
0 ImagesArt. -Nr.: HY-P3745CAS. Nr.: 65189-70-0
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MDL 27032
0 ImagesArt. -Nr.: HY-105517CAS. Nr.: 110124-55-5
