Prostaglandin Receptor
Prostaglandin receptor, a sub-family of cell surface seven-transmembrane receptors, are the G-protein-coupled receptors. There are currently ten known prostaglandin receptors on various cell types. Prostaglandins bind to a subfamily of cell surface seven-transmembrane receptors, G-protein-coupled receptors. These receptors are named: DP1-2-DP1, DP2 receptors, EP1-4-EP1, EP2, EP3, EP4 receptors, FP-FP, IP1-2-IP1, IP2 receptors, TP-TP receptor. The prostaglandins are a group of hormone-like lipid compounds that are derived enzymatically from fatty acids and have important functions in the animalbody. There are currently ten known prostaglandin receptors on various cell types.
Prostaglandin Receptor Isoform Specific Products
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Prostaglandin Receptor Inhibitors
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Prostaglandin Receptor Agonists
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Prostaglandin Receptor Antagonists
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Prostaglandin Receptor Activators
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Prostaglandin Receptor Modulators
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Prostaglandin Receptor Inducers
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Prostaglandin Receptor Degrader
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Prostaglandin Receptor Controls
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Prostaglandin Receptor Ligands
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Prostaglandin Receptor Related Products (766)
Related Products (766)
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Antibodies (2)
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Prostaglandin Receptor Isoform Comparison
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HA-29
0 ImagesCat. No.: HY-187632CAS No.: 142733-19-5HA-29 is an antiplatelet aggregation agent. HA-29 acts as a cyclooxygenase inhibitor and a thromboxane A2/prostaglandin endoperoxide receptor antagonist. HA-29 exerts its effects by inhibiting cyclooxygenase to block the formation of thromboxane A2 (TXA2), while simultaneously blocking the TXA2/prostaglandin endoperoxide receptor on platelets as a non-competitive antagonist. HA-29 can be used in antithrombotic research.
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ONO-AE3-208 sodium salt
0 ImagesCat. No.: HY-50901ACAS No.: 2309931-05-1Synonyms: AE 3-208 sodium saltONO-AE3-208 (sodium salt) is a selective and orally active EP4 receptor antagonist with a Ki of 1.3 nM. ONO-AE3-208 (sodium salt) shows less potently affects EP3, FP, and TP receptors (Ki of 30 nM, 790 nM, and 2400 nM, respectively). ONO-AE3-208 (sodium salt) suppresses cell invasion, migration, and metastasis of prostate cancer.
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TP receptor antagonist-1
0 ImagesCat. No.: HY-160615CAS No.: 1448452-21-8TP receptor antagonist-1 (compound 7m) is a thromboxane A2 receptor (TP receptor) antagonist, with IC50 values of 9.46 μM for TPa and 8.49 μM for TPb, respectively. TP receptor antagonist-1 can be used for the research of cardiovascular disease.
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O-Desmethyl-N-deschlorobenzoyl Indomethacin
0 ImagesCat. No.: HY-W740572CAS No.: 50995-53-4O-Desmethyl-N-deschlorobenzoyl indomethacin is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor indomethacin (HY-14397). It is formed from indomethacin in isolated rabbit hepatocytes. O-Desmethyl-N-deschlorobenzoyl indomethacin (600 μM) decreases the viability of HL-60 leukemia cells when cultured with glucose oxidase. It has also been used in the synthesis of prostaglandin D2 (HY-101988) receptor antagonists.
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CJ-42794 (Standard)
0 ImagesSynonyms: CJ-042794 (Standard)CJ-42794 (Standard) is the analytical standard of CJ-42794 (HY-10797). This product is intended for research and analytical applications. CJ-42794 (CJ-042794) is a potent, orally active, selective prostaglandin E receptor 4 (EP4) antagonist with an IC50 value of 10 nM, which is 200-fold more selective than EP1, EP2 and EP3. CJ-42794 can be used in research of gastric ulcers.
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AM211 sodium
0 ImagesCat. No.: HY-13213ACAS No.: 1263077-74-2AM211 sodium is a potent, selective and orally bioavailable prostaglandin D2 (PGD2) receptor type 2 (DP2) antagonist, with IC50s of 4.9 nM, 7.8 nM, 4.9 nM, 10.4 nM for human, mouse, guinea pig, and rat DP2, respectively.
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DG-041 (Standard)
0 ImagesCat. No.: HY-10835RCAS No.: 861238-35-9DG-041 (Standard) is the analytical standard of DG-041 (HY-10835). This product is intended for research and analytical applications. DG-041 is a potent, high affinity and selective EP3 receptor antagonist with IC50s of 4.6 nM and 8.1 nM in the binding and FLIPR assay, respectively. DG-041 inhibits PGE2 facilitation of platelet aggregation. DG-041 crosses the blood-brain barrier.
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LCB-2853
0 ImagesCat. No.: HY-101700CAS No.: 141335-10-6LCB-2853 is an antagonist of thromboxane A2 (TXA2) receptor, with antiplatelet and antithrombotic activities.
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RS-601
0 ImagesCat. No.: HY-U00072CAS No.: 207987-59-5RS-601 is a novel leukotriene D4 (LTD4)/thromboxane A2 (TxA2) dual receptor antagonist, with antiasthmatic activities.
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Fevipiprant (Standard)
0 ImagesSynonyms: QAW039 (Standard); NVP-QAW039 (Standard)Fevipiprant (Standard) is the analytical standard of Fevipiprant. This product is intended for research and analytical applications. Fevipiprant (QAW039, NVP-QAW039) is s an orally active, selective, reversible prostaglandin D2 (DP2) receptor antagonist with an Kd value of 1.14 nM. Fevipiprant has the potential for the research of bronchial asthma.
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MK-7246 S enantiomer
0 ImagesCat. No.: HY-15853ACAS No.: 2310135-53-4MK-7246 S enantiomer is the less active enantiomer of MK-7246. MK-7246 is a potent and selective CRTH2 antagonist.
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Pexopiprant L-lysine
0 ImagesCat. No.: HY-109186ACAS No.: 2155800-40-9Pexopiprant L-lysine is an oral antagonist of the prostaglandin D2 receptor 2 (DP2),Ki ＜ 100nM. Pexopiprant L-lysine can be used in studies of asthma.
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Ebopiprant hydrochloride
0 ImagesCat. No.: HY-112284ACAS No.: 2005486-32-6Synonyms: OBE022 hydrochlorideEbopiprant (OBE022) hydrochloride is an oral and selective prostaglandin F2α (PGF2α) receptor antagonist, with Kis of 1 nM, 26 nM for human and rat FP receptors, respectively.
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BGC-20-1531
0 ImagesCat. No.: HY-W394717CAS No.: 1186532-61-5Synonyms: PGN 1531BGC-20-1531 (PGN 1531), a benzenesulfonamide derivative, is a selective EP4 antagonist. BGC-20-1531 binds to PGE2 enhancing the ATPase activity, which are coupled to Gs proteins and thus activate adenylate cyclase generating cAMP and activating PKA. BGC-20-1531 is promising for research of liver disorders.
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BAY-1316957 (Standard)
0 ImagesCat. No.: HY-111539RCAS No.: 1613264-40-6BAY-1316957 (Standard) is the analytical standard of BAY-1316957 (HY-111539). This product is intended for research and analytical applications. BAY-1316957 is a potent, selective and orally active prostaglandin E2 receptor subtype 4 (EP4-R) antagonist with an IC50 of 15.3 nM for human EP4-R. BAY-1316957 has excellent agent metabolism and pharmacoKinetics properties, and can be used for endometriosis research.
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Palupiprant (Standard)
0 ImagesCat. No.: HY-103088RCAS No.: 1369489-71-3Synonyms: E7046 (Standard)Palupiprant (Standard) is the analytical standard of Palupiprant (HY-103088). This product is intended for research and analytical applications. Palupiprant (E7046) is an orally bioavailable and specific EP4 antagonist, with IC50 of 13.5 nM and Ki of 23.14 nM. Palupiprant exhibits anti-tumor activities.
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Terutroban (Standard)
0 ImagesCat. No.: HY-16991RCAS No.: 165538-40-9Synonyms: S-18886 (Standard)Terutroban (Standard) is the analytical standard of Terutroban. This product is intended for research and analytical applications. Terutroban (S-18886) is a selective and orally active thromboxane-prostaglandin (TP) receptor antagonist with an IC500 of 16.4 nM. Terutroban inhibits TXA2 and prostaglandin endoperoxide receptors. Terutroban is a potent antithrombotic agent and possesses antiatherosclerotic and antivasoconstrictor properties.
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YM158 free base
0 ImagesCat. No.: HY-U00355CAS No.: 179102-65-9Synonyms: YM-57158YM158 free base is a potent and selective LTD4 and TXA2 receptor antagonist with pA2 values of about 8.87 and 8.81, respectively.
