HA-29

HA-29 (10-100 μg/mL; 3 min) concentration-dependently inhibits thrombus formation and ATP release induced by Arachidonic acid (HY-109590) and Collagen (HY-P2738) in washed rabbit platelets, with IC₅₀ values of 42.0 μg/mL and 54.8 μg/mL, respectively. It does not affect platelet responses to ADP, platelet-activating factor, or thrombin, and its inhibitory activity is reversible. Additionally, at a concentration of 100 μg/mL, it suppresses Arachidonic acid-induced prostaglandin D₂ production^[1].
HA-29 (10-100 μg/mL; 3 min) acts as a non-competitive thromboxane A₂/prostaglandin endoperoxide receptor antagonist in washed rabbit platelets. It inhibits U-46619 (HY-108566)-induced aggregation with an IC₅₀ of 42.1 μg/mL. The resulting Schild plot yields a pA₂ value of 4.26 and a pA₁₀ value of 3.58, and HA-29 exerts a time-dependent disaggregatory effect on established U-46619-induced aggregation^[1].
HA-29 (100 μg/mL; 6 min) almost completely inhibits U-46619-induced inositol monophosphate production, but does not inhibit production induced by Collagen or Thrombin (HY-114164) in washed rabbit platelets labeled with [³H]inositol^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.