SOD
Superoxide Dismutase
SOD (Superoxide dismutase), an antioxidant enzyme, are a group of metalloenzymes that defenses against reactive oxygen species (ROS)-mediated injury. SOD can catalyze the dismutation of superoxide radicals (O2˙-) into hydrogen peroxide (H2O2) and oxygen (O2). The chemical moiety of SOD contains some metal ions such as Cu2+, Zn2+, Mn2+, and Fe2+ in the active site, which mediates the dismutation process. On the basis of these metallic cofactors, SOD can be classified into three distinct types, SOD1 (Cu/Zn-SOD), SOD2 (Mn-SOD), and SOD3 (Fe-SOD)[1][2].
References:
- [1]. Younus H. Therapeutic potentials of superoxide dismutase. Int J Health Sci (Qassim). 2018 May-Jun;12(3):88-93. [Content Brief]
- [2]. Saurav Suman, et al. Chapter 14 - Biotic stresses on plants: reactive oxygen species generation and antioxidant mechanism. Frontiers in Plant-Soil Interaction. Molecular Insights Into Plant Adaptation. 2021, 381-411.
All Product Categories
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SOD Related Products (234)
Related Products (234)
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Antibodies (4)
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Bovinic acid (Standard)
0 ImagesCat. No.: HY-113162RCAS No.: 2540-56-9Bovinic acid (Standard) is the analytical standard of Bovinic acid (HY-113162). This product is intended for research and analytical applications. Bovinic acid is an orally active anti-inflammatory agent. Bovinic acid inhibits oxidative stress and ferroptosis by regulating the Keap1-Nrf2 signaling pathway. Bovinic acid exerts hepatoprotective effects against alcohol-associated liver disease. Bovinic acid can be used for the research of alcohol-associated liver disease.
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Continentalic acid (Standard)
0 ImagesCat. No.: HY-N6908RCAS No.: 19889-23-7Continentalic acid (Standard) is the analytical standard of Continentalic acid (HY-N6908). This product is intended for research and analytical applications. Continentalic acid is a diterpenoid organic acid. Continentalic acid exhibits multiple activities including anti-inflammatory, antioxidant, neuroprotective, antibacterial and antitumor effects. Continentalic acid alleviates oxidative stress, reduces pro-inflammatory cytokine production, inhibits MAPK phosphorylation and neutrophil infiltration, and induces growth inhibition and apoptosis of cancer cells. Continentalic acid can be used in research related to traumatic brain injury, cancer, inflammation and infections.
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AG690
0 ImagesCat. No.: HY-189053CAS No.: 303970-80-1AG690 is a phenoloxidase inhibitor and immunosuppressant. AG690 reduces the expression and activity of phenoloxidase, inhibits cellular immune responses including hemocyte phagocytosis, nodule formation and encapsulation, and suppresses the activities of superoxide dismutase (SOD), peroxidase and lysozyme, thereby enhancing the insecticidal toxicity of λ-cyhalothrin against Spodoptera litura larvae. AG690 can be used as an insecticide synergist in related research.
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SC-55858
0 ImagesCat. No.: HY-129782CAS No.: 179464-49-4SC-55858 is an effective superoxide dismutase simulator. SC-55858 increased heart rate and decreased mean arterial pressure and left ventricular systolic and end-diastolic pressures in conscious dogs.
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Schisanhenol (Standard)
0 ImagesCat. No.: HY-N0859RCAS No.: 69363-14-0Synonyms: Schizanhenol (Standard); Gomisin-K3 (Standard)Schisanhenol (Standard) (Schizanhenol (Standard)) is the analytical standard of Schisanhenol (HY-N0859). This product is intended for research and analytical applications. Schisanhenol, a lignan, is an orally active antioxidant. Schisanhenol reduces AChE activity, increases SIRT1 and PGC-1α expression, and decreases phosphorylated Tau (Ser 396) levels. Schisanhenol increases SOD and glutathione peroxidase activity, decreases malondialdehyde (MDA) content, and inhibits UGT2B7 activitY. Schisanhenol attenuates ox-LDL-induced apoptosis, intracellular reactive oxygen species generation, and cytotoxicity in endothelial cells. Schisanhenol inhibits LDL oxidation, brain mitochondrial and membrane peroxidative damage, and brain mitochondrial swelling and disintegration. Schisanhenol can be used for the research of Alzheimer’s disease, atherosclerosis, brain ischemia, and age-related brain deterioration.
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Trinexapac-ethyl
0 ImagesTrinexapac-ethyl (TE) is well-known as an anti-gibberellin plant growth regulator.
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Malformin C
0 ImagesCat. No.: HY-P2005CAS No.: 59926-78-2Malformin C is an algicidal peptide can be isolated from Aspergillus and exhibits dose-dependent algicidal activity. Malformin C induces a significant increase in ROS levels in algal cells, resulting in impaired SOD activity and high production of MDA content.
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Nrf2/HO-1 activator 4
0 ImagesCat. No.: HY-184698CAS No.: 3072761-08-8Nrf2/HO-1 activator 4 is a Nrf2/HO-1 activator. Nrf2/HO-1 activator 4 inhibits nitric oxide production and the expression of pro-inflammatory cytokines IL-1β, IL-6, TNF-α, as well as upstream inflammatory enzymes COX-2 and iNOS. Nrf2/HO-1 activator 4 reduces ROS accumulation, and restores GSH levels and SOD activity. Nrf2/HO-1 activator 4 ameliorates depression-like behaviors in mice. Nrf2/HO-1 activator 4 can be used for research on major depressive disorder.
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Ethylenediaminetetraacetic acid disodium dihydrate (Standard)
0 ImagesSynonyms: EDTA disodium dihydrate (Standard)Ethylenediaminetetraacetic acid (disodium dihydrate) (Standard) is the analytical standard of Ethylenediaminetetraacetic acid (disodium dihydrate). This product is intended for research and analytical applications. Ethylenediaminetetraacetic acid (EDTA) disodium dehydrate is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid disodium dehydrate has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid disodium dehydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid disodium dehydrate can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid disodium dehydrate can be used for coronary artery disease and neural system disease research[4].
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Ethylenediaminetetraacetic acid-d4
0 ImagesCat. No.: HY-Y0682S2CAS No.: 15251-22-6Synonyms: EDTA-d4Ethylenediaminetetraacetic acid-d4 (EDTA-d4) is the deuterium labeled Ethylenediaminetetraacetic acid (HY-Y0682). Ethylenediaminetetraacetic acid (EDTA) is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research.
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CV 3611
0 ImagesCat. No.: HY-106797CAS No.: 98829-12-0CV 3611 is a potent and orally active free radical scavenger. CV 3611 shows anti-inflammatory, antiarrhythmic and anticancer effects. CV 3611 can be used for the researches of cancer, inflammation and cardiovascular disease, such as hepatocellular carcinoma and acute pancreatitis.
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FASN/SCD-IN-1
0 ImagesCat. No.: HY-176274CAS No.: 3063509-61-2FASN/SCD-IN-1 is a Silybin (HY-N0779A) derivative, an orally active inhibitor of Fatty Acid Synthase (FASN)/Stearoyl-CoA Desaturase (SCD). FASN/SCD-IN-1 has shown in vitro activity in inhibiting lipid deposition, reducing FASN and SCD transcriptional levels, and exhibiting antioxidant, anti-inflammatory, and anti-fibrotic activities. FASN/SCD-IN-1 has demonstrated significant hepatoprotective effects in a rat model of acute liver injury. FASN/SCD-IN-1 ameliorates the pathological features of MASH liver, including steatosis, inflammation, and fibrosis in a mouse model of myeloproliferative steatohepatitis (MASH). FASN/SCD-IN-1 can be used to study MASH.
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Auroglaucin
0 ImagesCat. No.: HY-N16406CAS No.: 41451-81-4Auroglaucin is a potent antioxidant. Auroglaucin shows 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging capacity and superoxide radical scavenging activity with EC50 value of 74.6, 12.3 µM, respectively. Auroglaucin shows low activity for inhibiting the autoxidation of docosahexaenoic acid (DHA).
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PPARγ agonist 20
0 ImagesCat. No.: HY-178447PPARγ agonist 20 is a potent, orally active PPAR-γ agonist. PPARγ agonist 20 effectively increases antioxidant defenses (SOD, GSH) and reduces lipid peroxidation. PPARγ agonist 20 can upregulate of Pparg, Glut4, and AdipoQ, suppresses of TNF-α, IL-6, and NF-κB p65. PPARγ agonist 20 significantly lowers fasting blood glucose, improving glucose tolerance, and restoring metabolic balance in Streptozotocin (HY-13753)-Nicotinamide (HY-B0150)-induced diabetic rats. PPARγ agonist 20 can be used for the study of type 2 diabetes.
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5-Hydroxyaloin A
0 ImagesCat. No.: HY-N11721CAS No.: 138373-23-65-Hydroxyaloin A is a polyphenolic antioxidant agent. 5-Hydroxyaloin A forms hydrogen bonding interactions at lipase’s active site and SOD’s active site with low binding energy. 5-Hydroxyaloin A inhibits microsomal lipid peroxidation induced by ferrous-cysteine, reducing malondialdehyde production. 5-Hydroxyaloin A can be used for the research of obesity.
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MiADMSA
0 ImagesCat. No.: HY-177995CAS No.: 142609-62-9Synonyms: Monoisoamyl meso-2,3-dimercaptosuccinic acidMiADMSA (Monoisoamyl meso-2,3-dimercaptosuccinic acid) is an orally active thiol chelator that can effectively remove heavy metals such as arsenic and lead from the body of animals. Arsenic binds with two vicinal sulfhydryl groups available in MiADMSA leading to marked reduction in body arsenic burden and also marked reduction in various oxidative stress parameters and antioxidant enzymes like-ROS, nitrite, TBARS, GSH, SOD and catalase. MiADMSA attenuates urinary bladder carcinogenesis, protects against oxidative stress, ameliorates copper-induced histopathology, reverses neurotoxicity, and is safe in animals. MiADMSA can be used in studies of bladder cancer, arsenic, and lead-induced developmental neurotoxicity.
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α-D-Manp(3→1)-α-D-Manp(2→1)-α-D-Glu
0 ImagesCat. No.: HY-181015α-D-Manp(3→1)-α-D-Manp(2→1)-α-D-Glu (Compound C) is an oligosaccharide. α-D-Manp(3→1)-α-D-Manp(2→1)-α-D-Glu activates the PI3K/AKT signaling pathway. α-D-Manp(3→1)-α-D-Manp(2→1)-α-D-Glu significantly inhibits Apoptosis by regulating the Bcl-2/BAX ratio. α-D-Manp(3→1)-α-D-Manp(2→1)-α-D-Glu shows cytoprotective activity by reducing ROS and LDH levels, decreasing MDA activity, and increasing CAT, SOD, and GSH activities. α-D-Manp(3→1)-α-D-Manp(2→1)-α-D-Glu shows neuroprotective effects and antioxidant capacity.
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Bartogenic acid
0 ImagesCat. No.: HY-N19717CAS No.: 79355-89-8Bartogenic acid is an orally active NF-κB inhibitor, found in Barringtonia racemosa fruits. Bartogenic acid increases catalase, superoxide dismutase (SOD), and glutathione levels. Bartogenic acid inhibits lipid peroxidation and suppresses inflammation markers. Bartogenic acid can be used for the research of ovarian cancer, skin cancer, and inflammatory conditions.
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HPO-DAEE
0 ImagesCat. No.: HY-158205CAS No.: 1895934-61-8Synonyms: 4-Hydroperoxy-2-decenoic acid ethyl esterHPO-DAEE (4-Hydroperoxy-2-decenoic acid ethyl ester) elicits nuclear accumulation of Nrf2 and activated antioxidant response element (ARE). HPO-DAEE induces antioxidant genes upregulation (eg: HO-1) through Nrf2-ARE signaling. HPO-DAEE induces reactive oxygen species generation. HPO-DAEE also inhibits histone deacetylase and upregulate expression of extracellular superoxide dismutase via histone acetylation. HPO-DAEE protects against 6-hydroxydopamine-induced cell death via activation of Nrf2-ARE and eIF2α-ATF4 pathways.
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Salicylcurcumin
0 ImagesCat. No.: HY-116117CAS No.: 1236545-54-2Salicylcurcumin is a synthetic curcumin analogue with antioxidant activity. Salicylcurcumin may affect lipid peroxidation in fish, favoring increased survival, disease resistance, and ultimately growth rate.
