VEGFR
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VEGFR Inhibitors
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VEGFR Chemical
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VEGFR Ligands
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VEGFR Related Products (403)
Related Products (403)
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EGFR-IN-26
0 ImagesCat. No.: HY-142518CAS No.: 2375470-64-5
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hCA/VEGFR-2-IN-1
0 ImagesCat. No.: HY-155694hCA/VEGFR-2-IN-1 (compound 13a) is a potent dual Carbonic Anhydrase(CA) IX/XII with Ki values of 4.7 nM and 8.3 nM for hCA XII and hCA IX, respectively. hCA/VEGFR-2-IN-1 (compound 13a) is a potent VEGFR-2 inhibitor with IC50 values 26.3 nM. hCA/VEGFR-2-IN-1 has anticancer activity.
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EG01449
0 ImagesCat. No.: HY-179350AEG01449 is a quinoline-based antagonist of Neuropilin-1 (NRP1) with an Kd of 0.6 µM. EG01449 competitively inhibits the binding of VEGFA to NRP1 with an IC50 of 362 nM. EG01449 prevents VEGFA-induced pain by inhibiting NRP1-dependent signaling and reducing sodium currents in sensory neurons. EG01449 can be used for the research of nociceptive pain.
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ZD-4190 hydrochloride
0 ImagesCat. No.: HY-U00002ACAS No.: 257938-36-6
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L-783277
0 ImagesCat. No.: HY-123586CAS No.: 791807-02-8L-783277 (Compound 4) is a MEK inhibitor (IC50 = 4 nM). L-783277 has potent inhibitory activity against a variety of kinases, including VEGFR2/3, FLT1/3/4, MEK1/2, KDR, and PDGFRα, but has low selectivity for the kinase community. L-783277 inhibits viability (IC50 = 22 mM) and cell proliferation (IC50 = 21 mM) of H295R cells. L-783277 could be used in research on cancers such as adrenocortical carcinoma.
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Anti-DCBLD2/ESDN Antibody (FA19-1)
0 ImagesCat. No.: HY-P990397Synonyms: FA19-1The Anti-DCBLD2/ESDN Antibody (FA19-1) is a humanized antibody expressed in CHO cells that targets DCBLD2/ESDN. The Anti-DCBLD2/ESDN Antibody (FA19-1) contains a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for the Anti-DCBLD2/ESDN Antibody (FA19-1) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
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Rabbit Thrombin
0 ImagesCat. No.: HY-114164ECAS No.: 9002-04-4Rabbit Thrombin is a serine protease. Rabbit Thrombin forms a covalent complex with antithrombin III and reversibly binds endothelial cell surface high-affinity sites. Rabbit Thrombin regulates VEGF and Ang-2, potentiates VEGF mitogenic activity and protects endothelial cells from apoptosis. Rabbit Thrombin can be used for the research of hindlimb ischemia.
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UB-925
0 ImagesCat. No.: HY-P991420UB-925 is a human monoclonal antibody (mAb) targeting VEGFR2/KDR/CD309. UB-925 can be used in Gastric cancer research.
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VEGFR-2/AURKA-IN-1
0 ImagesCat. No.: HY-155464VEGFR-2/AURKA-IN-1 (compound 5e) is a thiazolidin-4-one derivative with antiglioma activity (IC50: 6.43 μM, LN229). VEGFR-2/AURKA-IN-1 has affinity for AURKA and VEGFR-2 and is a potential ligand. VEGFR-2/AURKA-IN-1 causes DNA strand breaks and exhibits cytotoxic and anticancer potential.
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VGX200
0 ImagesCat. No.: HY-P991626VGX200 is a monoclonal antibody against vascular endothelial growth factor D (VEGFD).
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Pazopanib-13C,d3
0 ImagesCat. No.: HY-10208S1CAS No.: 1261734-88-6Synonyms: GW786034-13C,d3
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Anti-Human/Rat VEGF Antibody (A.4.6.1)
0 ImagesCat. No.: HY-P992082Anti-Human/Rat VEGF Antibody (A.4.6.1) is an antibody targeting human and rat vascular endothelial growth factor (VEGF) that potently inhibits tumor growth in various animal models. Anti-Human/Rat VEGF Antibody (A.4.6.1) is the parent antibody of Bevacizumab (HY-P9906), and it exhibits high affinity and high selectivity for binding to human VEGF. The isotype control for Anti-Human/Rat VEGF Antibody (A.4.6.1) is Mouse IgG1 kappa, Isotype Control (HY-P99977).
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Ethyl cinnamate (Standard)
0 ImagesEthyl cinnamate (Standard) is the analytical standard of Ethyl cinnamate. This product is intended for research and analytical applications. Ethyl cinnamate, an orally active chemical constituent of the rhizome of Kaempferia galanga, exhibits anti-cancer, nematocidal, sedative and vasorelaxant activities. Ethyl cinnamate is a fragrance ingredient used as a food flavor and additive for cosmetic products. Ethyl cinnamate is also an excellent clearing reagent for mammalian tissues. Ethyl cinnamate suppresses tumor growth through anti-angiogenesis by attenuating VEGFR2 signal pathway in colorectal cancer. Ethyl cinnamate inhibits the tonic contractions induced by high K+ and phenylephrine (PE) with respective IC50 values of 0.30 mM and 0.38 mM in rat aorta.
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AC-P19M
0 ImagesCat. No.: HY-P11198AC-P19M is an anticancer peptide. AC-P19M induces apoptosis by disrupting the cell membrane of cancer cells. AC-P19M reverses epithelial-mesenchymal transition (EMT). AC-P19M shows anti-angiogenic activity through the inhibition of VEGF-VEGFR2/ERK/Akt signaling. AC-P19M can be used for lung cancer research.
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Sunitinib-platinum(IV) prodrug-1
0 ImagesCat. No.: HY-179392Sunitinib-platinum(IV) prodrug-1 (Complex A) is a Pt(IV) prodrug based on Cisplatin (HY-17394), and this design aims to enable Pt(IV) to be reduced to active Pt(II) under intracellular reducing conditions, while simultaneously releasing a derivative of Sunitinib (HY-10255A) with tyrosine kinase inhibitor (TKI) activity. Sunitinib-platinum(IV) prodrug-1 exhibits excellent cytotoxicity against renal cell carcinoma (RCC), causing DNA crosslinking and apoptosis. Sunitinib-platinum(IV) prodrug-1 inhibits the VEGFR/PDGFR signaling pathway, suppressing tumor growth and angiogenesis. Sunitinib-platinum(IV) prodrug-1 can be used for research on renal cell carcinoma.
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ALN-3133 sodium scrambled negative control
0 ImagesCat. No.: HY-177614AALN-3133 sodium scrambled negative control is the sequence scrambled negative control of ALN-3133 sodium.
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B-Raf IN 17
0 ImagesCat. No.: HY-158027B-Raf IN 17 (Compound 8e) is a potent and orally active type II multi-kinase inhibitor. B-Raf IN 17 exhibits potent cellular-level suppression of BRAFWT, VEGFR-2, and FGFR-1 in A375 cell line, with IC50 values of 0.02, 0.18 and 1.65 μM, respectively. B-Raf IN 17 can be used for the research of cancer.
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Cabozantinib S-malate (Standard)
0 ImagesSynonyms: XL184 S-malate (Standard); BMS-907351 S-malate (Standard)Cabozantinib (S-malate) (Standard) is the analytical standard of Cabozantinib (S-malate). This product is intended for research and analytical applications. Cabozantinib S-malate (XL184 S-malate) is a potent multiple receptor tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively.
