Apolipoprotein
Plasma lipoprotein metabolism is regulated and controlled by the specific apolipoprotein (apo-) constituents of the various lipoprotein classes. The major apolipoproteins include apoE, apoB, apoA-I, apoA-II, apoA-IV, apoC-I, apoC-II, and apoC-III. Specific apolipoproteins function in the regulation of lipoprotein metabolism through their involvement in the transport and redistribution of lipids among various cells and tissues, through their role as cofactors for enzymes of lipid metabolism, or through their maintenance of the structure of the lipoprotein particles.
Apolipoprotein Isoform Specific Products
All Product Categories
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Apolipoprotein Related Products (88)
Related Products (88)
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Apolipoprotein Isoform Comparison
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Mipomersen
0 ImagesCat. No.: HY-148647CAS No.: 1000120-98-8Synonyms: ISIS 301012 free baseMipomersen (ISIS 301012 free base) is an antisense oligonucleotide inhibitor of apolipoprotein B (apoB). Mipomersen has anti-HCV effect and reduces the infectivity of the HCV. Mipomersen can be used for the research of homozygous familial hypercholesterolemia (HoFH).
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Plozasiran sodium
0 ImagesSynonyms: ARO-APOC3 sodiumPlozasiran sodium is an siRNA targeting APOC3 for the study of mixed hyperlipidemia.
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Olezarsen
0 ImagesCat. No.: HY-153491CAS No.: 2097587-83-0Synonyms: ISIS 678354; IONIS-APOCIII-LRx; AKCEA-APOCIII-LRxOlezarsen (ISIS 678354;IONIS-APOCIII-LRx) is a GalNAc-modified antisense oligonucleotide. Olezarsen binds to APOC3 mRNA and induces its degradation via ribonuclease H1-mediated sense strand cleavage, thereby reducing hepatic apolipoprotein C-III (apoC-III) synthesis. Olezarsen reduces plasma triglyceride, apolipoprotein B and non-high-density lipoprotein cholesterol levels. Olezarsen is applicable to research related to familial chylomicronemia syndrome, hypertriglyceridemia and atherosclerotic cardiovascular disease.
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Pelacarsen sodium
0 ImagesSynonyms: AKCEA-APO(a)-LRx sodium; ISIS 681257 sodium; TQJ230 sodiumPelacarsen sodium (ISIS 681257 sodium) is a GalNAc3-conjugated 2′-MOE-modified antisense oligonucleotide. Pelacarsen sodium reduces apo (a).
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Plozasiran
0 ImagesSynonyms: ARO-APOC3Plozasiran is an siRNA targeting APOC3 for the study of mixed hyperlipidemia.
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Olezarsen sodium
0 ImagesCat. No.: HY-153491ACAS No.: 2298451-31-5Synonyms: ISIS 678354 sodium; IONIS-APOCIII-LRx sodium; AKCEA-APOCIII-LRx sodiumOlezarsen (ISIS 678354;IONIS-APOCIII-LRx) sodium is a GalNAc-modified antisense oligonucleotide. Olezarsen sodium binds to APOC3 mRNA and induces its degradation via ribonuclease H1-mediated sense strand cleavage, thereby reducing hepatic apolipoprotein C-III (apoC-III) synthesis. Olezarsen sodium reduces plasma triglyceride, apolipoprotein B and non-high-density lipoprotein cholesterol levels. Olezarsen sodium is applicable to research related to familial chylomicronemia syndrome, hypertriglyceridemia and atherosclerotic cardiovascular disease.
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CS-6253 TFA
0 ImagesCat. No.: HY-P6306APurity: 98.08%CS-6253 TFA is an agonist of ABCA1. CS-6253 TFA can regulate lipoprotein metabolism, promote high-density lipoprotein biogenesis, and cellular cholesterol efflux. CS-6253 TFA also has certain neuroprotective effects and can clear Aβ from the brain. CS-6253 TFA can be used for research on cholesterol metabolism and diseases such as Alzheimer’s disease.
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Lepodisiran
0 ImagesCat. No.: HY-177640CAS No.: 2808361-18-2Synonyms: LY3819469Lepodisiran (LY3819469) is a GalNAc-conjugated small interfering RNA lipid-lowering agent. Lepodisiran targets the hepatic LPA gene and degrades apolipoprotein (a) mRNA to silence its expression, thereby effectively reducing the production of apolipoprotein (a) and serum lipoprotein (a) in a dose-dependent manner. Lepodisiran can be used in studies related to atherosclerotic cardiovascular disease.
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APOL1-IN-1
0 ImagesAPOL1-IN-1 is an apolipoprotein L1 (APOL1) inhibitor that suppresses the functional activity of the APOL1 G1 risk variant. APOL1-IN-1 inhibits the pore function of APOL1, thereby reducing APOL1-mediated membrane permeability and abnormal ion flux, and thus intervenes in APOL1-related cellular injury processes. APOL1-IN-1 is used in research related to focal segmental glomerulosclerosis and non-diabetic kidney disease.
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Opemalirsen sodium
0 ImagesCat. No.: HY-177653ACAS No.: 2639854-33-2Synonyms: AZD2373 sodium, ION-972190 sodiumOpemalirsen sodium is an antisense oligonucleotide targeted to apolipoprotein L1 (APOL1). It is used for the study of Kidney disorders.
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Volanesorsen scramble negative control
0 ImagesCat. No.: HY-145727CPurity: 98.82%Synonyms: ISIS 304801 scramble negative controlVolanesorsen scramble negative control is a negative control for volanesorsen (HY-145727) with the sequence: CAUGUTCUTCUGCATGUCAU. Volanesorsen (ISIS 304801) is an antisense oligonucleotide inhibitor of apolipoprotein CIII (apo-CIII) mRNA that can lower triglyceride levels and improve insulin resistance.
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Zerlasiran
0 ImagesCat. No.: HY-147425CAS No.: 2646703-64-0Synonyms: SLN360Zerlasiran (SLN360) is a siRNA targeting apolipoprotein A (ApoA). Zerlasiran targets hepatic ApoA synthesis via RNA interference to degrade encoding mRNA. Zerlasiran can be used for the research of atherosclerotic cardiovascular disease and elevated ApoA levels.
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Pelacarsen
0 ImagesCat. No.: HY-151123CAS No.: 1637637-70-7Synonyms: AKCEA-APO(a)-LRx; ISIS 681257; TQJ230Pelacarsen (ISIS 681257) is a GalNAc3-conjugated 2′-MOE-modified antisense oligonucleotide. Pelacarsen reduces apo (a).
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2′-O-Methyluridine-d3
0 ImagesCat. No.: HY-W011824SPurity: 99.19%2′-O-Methyluridine-d3 is deuterium labeled 2′-O-Methyluridine (HY-W011824).2’-O-Methyluridine is a modified nucleoside that can be found in T. thermophile tRNA. 2’-O-Methyluridine level in serum is decreased in patients with breast cancer.
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2′-O-Methyluridine (Standard)
0 Images2′-O-Methyluridine (Standard) is the analytical standard of 2′-O-Methyluridine (HY-W001824). This product is intended for research and analytical applications. 2’-O-Methyluridine is a modified nucleoside that can be found in T. thermophile tRNA. 2’-O-Methyluridine level in serum is decreased in patients with breast cancer.
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3-Iodo-L-thyronine
0 ImagesSynonyms: 3-Monoiodothyronine3-Iodo-L-thyronine (3-Monoiodothyronine) is a thyroid hormone metabolite. 3-iodo-L-thyronine can bind to apolipoprotein B-100 (apoB-100).
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LVGRQLEEFL (mouse) TFA
0 ImagesCat. No.: HY-P5169ALVGRQLEEFL (mouse) TFA can be named as G * peptide, corresponding to amino acids 113 to 122 in apolipoprotein J ([113,122] apoJ)}. LVGRQLEEFL (mouse) TFA exhibits anti-inflammatory and anti-atherogenic properties. LVGRQLEEFL (mouse) TFA can be added to an apoJ mimetic, to form HM-10/10 peptide, which is a mimetic peptide and a novel chimeric high density lipoprotein. HM-10/10 peptide protects retinal pigment epithelium (RPE) and photoreceptors from oxidant induced cell death.
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Sultosilic acid piperazine salt
0 ImagesCat. No.: HY-130587CAS No.: 57775-27-6Synonyms: Piperazine sultosylate; A-585Sultosilic acid piperazine salt (Piperazine sultosylate; A-585) is a lipid-lowering agent. Sultosilic acid piperazine salt modifies the blood lipids levels, reduces platelet adhesiveness without promoting peroxisomal activity of hepatocytes or producing other adverse side-effects.
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Terbufibrol
0 ImagesTerbufibrol is an orally active lipid-lowering agent. Terbufibrol inhibits hepatic Cholesterol 7 alpha-hydroxylase. Terbufibrol blocks a step between Acetate and HMG-CoA in the hepatic cholesterol synthesis process. Terbufibrol reduces serum total cholesterol, HDL, LDL, lipoprotein levels, and the cholesterol/phospholipid ratio, with dose- and sex-dependent changes in lipoprotein components. Terbufibrol exerts sustained cholesterol-lowering activity in baboons and rats. Terbufibrol can be used in research related to hypercholesterolemia.
