Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Inhibitors
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Drug Derivative Controls
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Drug Derivative Related Products (4062)
Related Products (4062)
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O-Demethylrotenone
0 ImagesCat. No.: HY-N11732CAS No.: 36375-21-0O-Demethylrotenone is a rotenone (HY-B1756) derivative and a photodegradation product of rotenone that induces acute intraperitoneal toxicity. The acute intraperitoneal LD50 of O-Demethylrotenone in Mus musculus is 8.0 mg/kg.
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Motretinide
0 ImagesCat. No.: HY-122299CAS No.: 56281-36-8Synonyms: Ro 11-1430Motretinide (Ro 11-1430) is an aromatic retinoic acid with teratogenic activity. Motretinide can be used in studies on medication guidance during pregnancy.
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C6 Biotin ganglioside gm3 (d18:1/6:0) ammonium
0 ImagesCat. No.: HY-173643Synonyms: Biotin-C6:0-gm3 ammonium; N-Hexanoyl-biotin-monosialoganglioside gm3 ammoniumC6 Biotin ganglioside gm3 (d18:1/6:0) (Biotin-C6:0-gm3) ammonium is a derivative of ganglioside GM3. C6 Biotin ganglioside gm3 (d18:1/6:0) ammonium can be used to detect or immobilize ganglioside GM3 through interaction with the biotin ligand.
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27-Epichantrieroside A
0 ImagesCat. No.: HY-N16984CAS No.: 290809-72-227-Epichantrieroside A is a natural steroid.
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Nek2/Hec1-IN-1
0 ImagesCat. No.: HY-136747CAS No.: 560103-80-2Synonyms: Nec2/Hec1 inhibitorN-[4-(2,4-Dimethylphenyl)-2-thiazolyl]-4-pyridinecarboxamide is a derivative of INH1 with anticancer activity. It is cytotoxic to MDA-MB-231, MDA-MB-488, HeLa, and K562 cells (IC50s=1.1, 3.4, 1.6, and 1.2 μM, respectively).
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3,8-Dioxo-7α-hydroxy-4,11(12)-tetradehydrocadinanene
0 ImagesCat. No.: HY-N2742CAS No.: 1423809-64-63,8-Dioxo-7α-hydroxy-4,11(12)-tetradehydrocadinanene is a natural sesquiterpene.
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Acetylagmatine acetate
0 ImagesCat. No.: HY-172532CAS No.: 2108663-32-5Synonyms: N-Acetylagmatine acetateAcetylagmatine (N-Acetylagmatine) acetate is a product formed by agmatine N-acetyltransferase (AgmNAT) catalyzing the reaction of acetyl-CoA and Agmatine (HY-101238). Agmatine is the product of arginine decarboxylation. Agmatine is a neurotransmitter and neuromodulator in mammalian brain.
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8-Methoxyfissistigine C
0 ImagesCat. No.: HY-N7351CAS No.: 20824-18-48-Methoxyfissistigine C is a natural alkaloid.
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N-Ethyl 2C-B hydrochloride
0 ImagesCat. No.: HY-W753724CAS No.: 155638-84-9N-Ethyl 2C-B hydrochloride is a phenethylamine with psychoactive properties.
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9,10-Dihydroxymegastigma-4,7-dien-3-one
0 ImagesCat. No.: HY-N17126CAS No.: 349642-88-29,10-Dihydroxymegastigma-4,7-dien-3-one is a natural sesquiterpene.
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SDZ-MRL 953
0 ImagesCat. No.: HY-106847CAS No.: 123136-61-8SDZ-MRL 953 is a novel immunostimulatory lipid analogue. SDZ-MRL 953 has no pulmonary toxicity and good safety. SDZ-MRL 953 can be used for research on acute lung injury.
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BIBS-222
0 ImagesCat. No.: HY-125080CAS No.: 142023-57-2BIBS-222 is an active compound.
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Botrytone
0 ImagesCat. No.: HY-N16730CAS No.: 1322069-08-8Botrytone is a natural phenolic compound.
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Anti-inflammatory agent 34
0 ImagesAnti-inflammatory agent 34 (Compound IVf) is an orally active anti-inflammatory and analgesic agent.
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3-Methoxy limaprost
0 ImagesCat. No.: HY-158579CAS No.: 1224443-96-2Synonyms: 3-Methoxy-2,3-dihydro-limaprost3-Methoxy Limaprost is a derivative of Limaprost. Limaprost is a?PGE1?analogue and a potent and orally active vasodilator.
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Celivarone
0 ImagesCat. No.: HY-106207CAS No.: 401925-43-7Synonyms: SSR149744CCelivarone (SSR149744C) is a orally active noniodinated benzofuran derivative with antiarrhythmic properties. Celivarone has the potential for atrial fibrillation and in ventricular arrhythmias research.
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5α,6α-Epoxyergosta-8(14),22-diene-3β,7α-diol
0 ImagesCat. No.: HY-N17230CAS No.: 22259-18-35α,6α-Epoxyergosta-8(14),22-diene-3β,7α-diol is a natural steroid.
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Ormaplatin
0 ImagesCat. No.: HY-105522CAS No.: 62816-98-2Synonyms: Tetraplatin; NSC 363812Ormaplatin (Tetraplatin) is a Platinum (HY-W096169D) analog with anticancer activity. Ormaplatin demonstrates cytotoxic activity in Cisplatin (HY-17394)-sensitive cell lines in vitro and in vivo. Ormaplatin can be used for non-small cell lung, colon, and breast cancer research.
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WAY-271999
0 ImagesWAY-271999 is an active molecule.
