Drug Isomer
Drug Isomer
Drug isomers are compounds with the same molecular formula but different atomic arrangements or spatial configurations. They are divided into structural isomers and stereoisomers, and have different biological activities, safety and metabolic characteristics. Drug isomers can be used as drug improvement groups or drug efficacy control groups. For example, Carvedilol has higher bioavailability and better safety than (R)-Carvedilol.
参考文献:
- [1]. Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14. [Content Brief]
- [2]. Andersson T. Single-isomer drugs: true therapeutic advances. Clin Pharmacokinet. 2004;43(5):279-85. [Content Brief]
- [3]. Chhabra N, et al. A review of drug isomerism and its significance. Int J Appl Basic Med Res. 2013 Jan;3(1):16-8. [Content Brief]
All Product Categories
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Drug Isomer 関連製品 (546)
関連製品 (546)
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(-)-Epipinoresinol
0 Images製品番号: HY-N7534ACAS 番号: 10061-38-8(-)-Epipinoresinol is an isomer of the lignan (+)-Epipinoresinol. CYP81Q3 specifically catalyzes the formation of the methylenedioxy bridge (MDB) in (+)-Epipinoresinol to produce (+)-Pluviatilol.
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PB-22 5-Hydroxyquinoline isomer
0 Images製品番号: HY-172040CAS 番号: 1885091-23-5PB-22 5-hydroxyquinoline isomer is a structural isomer of PB-22. PB-22 is a cannabinoid.
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(2S,3R)-Fadraciclib
0 Images製品番号: HY-101212A(2S,3R)-Fadraciclib is the 2S,3R isomer of Fadraciclib (HY-101212). Fadraciclib is an orally potent ATP-competitive CDK2/CDK9 kinase inhibitor with IC50 values of 5 and 26 nM, respectively.
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Isomalathion
0 Images製品番号: HY-W707749CAS 番号: 3344-12-5Isomalathion is an isomer and impurity of Malathion (HY-B0943). Isomalathion inhibits Carboxyesterase and AChE, with an IC50 value of 3.2 μM against bovine acetylcholinesterase. Isomalathion moderately reduces CYP1A2 transcript levels, increases CYP2B6 transcript levels, and induces dose-dependent DNA damage. Malathion is an organophosphorus insecticide.
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(R)-Ozanimod hydrochloride
0 Images製品番号: HY-W751034ACAS 番号: 1306760-85-9別名: (R)-RPC-1063 hydrochloride(R)-Ozanimod (hydrochloride) is the R-isomer of Ozanimod hydrochloride (HY-12288A).
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(Rac)-Germacrene D
0 Images製品番号: HY-129155CAS 番号: 37839-63-7(Rac)-Germacrene D is a natural product that can be isolated from the genus Bursera.
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2-Hydroxymethyl-5-hydroxypyridine (Standard)
0 Images製品番号: HY-W007140RCAS 番号: 40222-77-32-Hydroxymethyl-5-hydroxypyridine (Standard) is the analytical standard of 2-Hydroxymethyl-5-hydroxypyridine (HY-W007140). This product is intended for research and analytical applications. 2-Hydroxymethyl-5-hydroxypyridine is isolated from the the matured, ripened and dried seeds of S. lychnophora.
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(1R)-1,2-Dilauroyl-sn-glycerol
0 Images製品番号: HY-128465ACAS 番号: 61475-84-1(1R)-1,2-Dilauroyl-sn-glycerol is the R isomer of 1,2-Dilauroyl-sn-glycerol (HY-128465). 1,2-Dilauroyl-sn-glycerol is a saturated diacylglycerol and may play a role in second messenger signal transduction.
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PB-22 6-Hydroxyisoquinoline isomer
0 Images製品番号: HY-172051CAS 番号: 1797131-58-8PB-22 6-Hydroxyisoquinoline isomer is a structural isomer of PB-22. PB-22 is a cannabinoid.
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(Z)-JIB-04 (Standard)
0 Images製品番号: HY-107842RCAS 番号: 199596-24-2別名: NSC693627 (Standard)(Z)-JIB-04 (Standard) is the analytical standard of (Z)-JIB-04 (HY-107842). This product is intended for research and analytical applications. (Z)-JIB-04 (NSC693627) is the Z isomer of JIB-04 that has two forms, E (HY-13953) and Z isomers. (Z)-JIB-04 is inactive in epigenetic analysis.
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D-NAME
0 Images製品番号: HY-18729BCAS 番号: 141968-19-6別名: NG-Nitro-D-arginine methyl esterD-NAME (NG-Nitro-D-arginine methyl ester) is an orally active enantiomer of L-NAME (HY-18729). D-NAME inhibits Nitric oxide synthase activity in myocardium and aorta (Note: D-NAME was once classified as an inactive substance and used as a negative control in nitric oxide synthase inhibition studies), induces increases in systolic blood pressure and mean arterial blood pressure, reduces mesenteric arterial conductance, elevates the ratio of left ventricular weight to body weight, induces myocardial fibrosis, increases the cross-sectional area of aortic wall, enhances mesenteric vasodilation induced by nitrovasodilators, and releases nitric oxide via its guanidino nitro group. D-NAME has no effect on ovalbumin-induced pulmonary eosinophilia in sensitized mice. D-NAME can be used in hypertension-related research.
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ent-Epanorin
0 Images製品番号: HY-177539CAS 番号: 3061155-25-4ent-Epanorin is an enantiomer of Epanorin (HY-N16418). ent-Epanorin has more potent antibacterial and antiparasitic activity against Bacillus subtilis (ATCC 6633), Staphylococcus aureus (ATCC 25923) and Giardiaduodenalis 713 compared to Epanorin.
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cis-ICeD-2
0 Images製品番号: HY-151871Acis-ICeD-2 is the cis isomer of ICeD-2 (HY-151871). ICeD-2 is a cell death inducer that induces cell death in HIV-1-infected cells. ICeD-2-mediated killing of HIV-1-infected cells is dependent on HIV-1 protease activity. ICeD-2 effectively blocks the hydrolysis of Gly-Pro-AMC by the dipeptidyl peptidases DPP8 and DPP9. ICeD-2 demonstrates strong stability against DPP9 in PBMCs..
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N-Acetyl-D-glucosamine-d3
0 Images製品番号: HY-A0132S14CAS 番号: 77369-11-0別名: N-Acetyl-2-amino-2-deoxy-D-glucose-d3N-Acetyl-D-glucosamine-d3 (N-Acetyl-2-amino-2-deoxy-D-glucose-d3) is deuterium labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose), the D isomer of N-acetylglucosamine, is an orally active monosaccharide derivative of glucose with anti-tumor and anti-inflammation properties. N-Acetyl-D-Glucosamine is also a bacterial metabolite, which is found in Escherichia coli. N-Acetyl-D-Glucosamine can induce yeast-mycelial conversion in Candida albicans. N-Acetyl-D-Glucosamine also enhances healing of cartilaginous injuries in rabbits.
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(1S,3S)-λ-Cyhalothrin
0 Images製品番号: HY-B0836ACAS 番号: 76703-65-6(1S,3S)-λ-Cyhalothrin is an isomer of λ-Cyhalothrin (HY-B0836). λ-Cyhalothrin is a highly potent, broad-spectrum, Type II synthetic pyrethroid Insecticide.
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rel-Hydroxy Itraconazole
0 Images製品番号: HY-12772ACAS 番号: 207970-87-4別名: rel-R-63373rel-Hydroxy Itraconazole (rel-R-63373) is a relative stereoisomer of Hydroxy Itraconazole. Hydroxy Itraconazole is the major active metabolite of the antifungal compound Itraconazole (HY-17514).
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(R)-IRF4 ligand-1
0 Images製品番号: HY-185698ACAS 番号: 3088682-64-5(R)-IRF4 ligand-1 is an isomer of IRF4 ligand-1 (HY-185698). IRF4 ligand-1 is an IRF4 ligand that can be used for the synthesis of PROTACs, such as dIRF4-2 (HY-185697).
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(Z)-Doxepin
0 Images(Z)-Doxepin is an isomer of Doxepin (HY-B0725A). Doxepin is an orally active, blood-brain barrier penetrant tricyclic antidepressant with multiple activities including hypnosis, sedation, analgesia and vasodilation. Doxepin enhances the expression of PSD-95 and synapsin 1 via the PI3K/AKT/mTOR signaling pathway, and is metabolized to Desmethyldoxepin in vivo. Doxepin can be used in research related to various diseases such as depression, anxiety, obesity and atopic dermatitis.
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Enitociclib (Standard)
0 Images製品番号: HY-103019RCAS 番号: 1610408-97-3別名: (+)-BAY-1251152 (Standard); (+)-VIP152 (Standard); (S)-Enitociclib (Standard)Enitociclib (Standard) is the analytical standard of Enitociclib (HY-103019). This product is intended for research and analytical applications. Enitociclib ((+)-BAY-1251152; (+)-VIP152) is a selective CDK9 inhibitor (IC50=3 nM) that inhibits transcriptional elongation by blocking Ser2/Ser5 phosphorylation of RNA polymerase II. Enitociclib specifically depletes key short-lived proteins such as c-MYC, MCL-1 and induces tumor cell apoptosis. Enitociclib also interferes with the production of enhancer RNAs (eRNA) and enhancer-promoter interactions, and downregulates oncogene expression at the epigenetic level. Enitociclib exerts synergistic effects with agents including Bortezomib (HY-10227), Lenalidomide (HY-A0003), Pomalidomide (HY-10984), Venetoclax (HY-15531) and Paclitaxel (HY-B0015), and even reverses paclitaxel resistance. Enitociclib serves as a vital research tool for various malignancies such as double-hit diffuse large B-cell lymphoma, multiple myeloma and pancreatic ductal adenocarcinoma.
