Drug Isomer
Drug Isomer
Drug isomers are compounds with the same molecular formula but different atomic arrangements or spatial configurations. They are divided into structural isomers and stereoisomers, and have different biological activities, safety and metabolic characteristics. Drug isomers can be used as drug improvement groups or drug efficacy control groups. For example, Carvedilol has higher bioavailability and better safety than (R)-Carvedilol.
References:
- [1]. Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14. [Content Brief]
- [2]. Andersson T. Single-isomer drugs: true therapeutic advances. Clin Pharmacokinet. 2004;43(5):279-85. [Content Brief]
- [3]. Chhabra N, et al. A review of drug isomerism and its significance. Int J Appl Basic Med Res. 2013 Jan;3(1):16-8. [Content Brief]
All Product Categories
-
Drug Isomer Related Products (557)
Related Products (557)
-
(±) Anabasine (Standard)
0 Images(±) Anabasine (Standard) is the analytical standard of (±) Anabasine (HY-W052144). This product is intended for research and analytical applications. (±) Anabasine is the racemic form of Anabasine (HY-B1532). (±) Anabasine stimulates the release of [3H]-Dopamine from mouse striatal synaptosomes. (±) Anabasine inhibits the high-affinity binding of [3H]-S-(-)-Nicotine to the striatal membrane. Anabasine is an agonist of α7nAChR and possesses anti-inflammatory and insecticidal activities.
-
meso-Astaxanthin
0 ImagesCat. No.: HY-N13470CAS No.: 71772-51-5meso-Astaxanthin is a natural stereoisomer of Astaxanthin (HY-B2163) with antioxidant activity and is found in a variety of aquatic animals. meso-Astaxanthin binds to human serum albumin in a monomeric form at a stoichiometric ratio; at low ligand-to-protein ratios, human serum albumin acts as a chiral template for supramolecular assembly at higher ratios. meso-Astaxanthin directly scavenges superoxide anions. meso-Astaxanthin can be used in the research of myocardial ischemia-reperfusion injury.
-
rel-Avibactam
0 ImagesCat. No.: HY-187660CAS No.: 396731-14-9Synonyms: rel-NXL-104 free acid; rel-AVE1330A free acidrel-Avibactam (rel-NXL-104 free acid) is an isomer of Avibactam (HY-14879). Avibactam is a β-lactamase inhibitor with an IC50 of 8 nM against TEM-1 β-lactamase and an IC50 of 80 nM against P99 β-lactamase. Avibactam exhibits no significant intrinsic antibacterial activity when used alone. Avibactam restores the activity of Ceftazidime (HY-B0593) against β-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa. Avibactam does not enhance the activity of Ceftazidime against Acinetobacter spp., Burkholderia spp., or most anaerobic Gram-negative bacilli. Avibactam is used in research related to Gram-negative bacterial infections.
-
Oxiran-2-ylmethanol-d5
0 ImagesCat. No.: HY-Y1010SCAS No.: 1246819-20-4Synonyms: Glycidol-d5Oxiran-2-ylmethanol-d5 is the deuterium labeled Oxiran-2-ylmethanol (Glycidol) (HY-Y1010). Oxiran-2-ylmethanol is an ester product. Oxiran-2-ylmethanol induces base pair point mutations in bacterial strains and structural chromosome aberrations in cultured cells. Oxiran-2-ylmethanol forms N-(2,3-dihydroxypropyl)valine hemoglobin adducts. Oxiran-2-ylmethanol acts as an animal carcinogen but does not significantly induce micronucleated immature erythrocytes in animal bone marrow. Oxiran-2-ylmethanol enables anionic polymerization to produce linear poly(glycidol). Oxiran-2-ylmethanol can be used for cancer-related research.
-
(R,R)-Voriconazole
0 ImagesCat. No.: HY-76200CCAS No.: 239807-03-5Synonyms: (R,R)-UK-109496(R,R)-Voriconazole ((R,R)-UK-109496) is an enantiomer of Voriconazole (HY-76200). Voriconazole (UK-109496) is a second-generation broad-spectrum triazole antifungal compound that inhibits the biosynthesis of fungal ergosterol. Voriconazole exerts its antifungal activity by inhibiting the 14-α-lanosterol demethylation mediated by fungal cytochrome P450 enzymes. Voriconazole exhibits blood-brain barrier permeability.
-
Golgicide A-1 (Standard)
0 ImagesCat. No.: HY-100540CRCAS No.: 1394285-49-4Synonyms: GCA-1 (Standard)Golgicide A-1 (Standard) is the analytical standard of Golgicide A-1 (HY-100540C). This product is intended for research and analytical applications. Golgicide A-1 (GCA-1) is a less active cis-diastereomer of Golgicide A (GCA). Golgicide A-1 weakly inhibits mosquito reproduction.
-
2,2'-Methylenediphenyl diisocyanate
0 Images2,2'-Methylenediphenyl diisocyanate (2,2′-MDI) is a sensitizer and an isomer of methylenediphenyl diisocyanate (MDI). 2,2'-Methylenediphenyl diisocyanate induces contact sensitization upon skin contact. 2,2'-Methylenediphenyl diisocyanate is used in studies of allergic contact dermatitis.
-
(-)-Chloroquine
0 ImagesCat. No.: HY-W614112CAS No.: 58175-87-4(-)-Chloroquine is a chloroquine enantiomer.
-
3'-(2-Fluorophenyl) ezetimibe
0 ImagesCat. No.: HY-Z3151CAS No.: 1798008-25-93'-(2-Fluorophenyl) ezetimibe is an isomer of the cholesterol transport inhibitor Ezetimibe (HY-17376).
-
(Z)-Rilpivirine
0 ImagesCat. No.: HY-167642CAS No.: 500287-94-5Synonyms: (Z)-R278474; (Z)-TMC278; (Z)-DB08864(Z)-Rilpivirine ((Z)-R278474) is the (Z)-isomer of Rilpivirine (HY-10574). Rilpivirine is an effective and selective diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). It exhibits potent antiviral activity against both wild-type HIV (EC50 = 0.4 nM) and mutant strains (EC50 = 0.1-2.0 nM).
-
(Rac)-IDO1-IN-30
0 ImagesCat. No.: HY-178479A(Rac)-IDO1-IN-30 is the Rac isomer of IDO1-IN-30 (HY-178479). IDO1-IN-30 is a potent and highly selective IDO1 inhibitor. IDO1-IN-30 has an IC50 of 4.8 nM to IDO1 in SKOV3 cells. IDO1-IN-30 does not show significant cytotoxicity at 25 µM in HepG2 cells. IDO1-IN-30 can eliminate inhibition of CYP450 enzymes (such as 3A4, 2C9, 2D6). IDO1-IN-30 can be used for research on cancer and inflammatory conditions.
-
(S)-Lisofylline (Standard)
0 ImagesCat. No.: HY-109854RCAS No.: 100324-80-9Synonyms: (S)-Lisophylline (Standard)(S)-Lisofylline (Standard) is the analytical standard of (S)-Lisofylline (HY-109854). This product is intended for research and analytical applications. (S)-Lisofylline ((S)-Lisophylline)) is a Kind of lisofline (LSF) enantiomer with optical activity. (S)-Lisofylline can interconversion with pentoxifylline.
-
(S)-Isomyosmine
0 ImagesCat. No.: HY-163103CAS No.: 67209-94-3(S)-Isomyosmine is the S-enantiomer of Isomyosmine (HY-W701069). Isomyosmine is a nitrate reductase inhibitor. Isomyosmine is a nicotine related alkaloid present in solanecea plants containing nicotine. Isomyosmine can be used for research of inflammation and age-related disorders.
-
5-Fluoro PB-22 7-hydroxyisoquinoline isomer
0 ImagesCat. No.: HY-172049CAS No.: 2365471-81-25-Fluoro PB-22 7-hydroxyisoquinoline isomer is a structural isomer of 5-Fluoro PB-22.
-
(+)-5-trans Cloprostenol isopropyl ester
0 ImagesCat. No.: HY-100571A(+)-5-trans Cloprostenol isopropyl ester is a more lipid-soluble form of (+)-5-trans cloprostenol (HY-120955), which is a synthetic derivative of prostaglandin F2α.
-
(4R,5S)-RG7112D
0 ImagesCat. No.: HY-158685A(4R,5S)-RG7112D is an isomer of RG7112D (HY-158685). The IC50 values of RG7112D for inhibiting MDM2-p53 and VHL-HIF1α are 11 nM and >10000 nM, respectively. (4R,5S)-RG7112D can be used in studies related to PROTAC synthesis, for example, serving as the target protein ligand of (4R,5S)-YX-02-030 (HY-158684A).
-
Neomycin C hexaacetate
0 ImagesCat. No.: HY-131130ANeomycin C hexaacetate is an impurity of Neomycin (HY-150520) and a stereoisomer of Neomycin B (HY-17624). Neomycin C hexaacetate exerts in vitro antimicrobial activity against Staphylococcus epidermidis and Staphylococcus aureus. Neomycin C hexaacetate can be used for the research of bacterial infection.
-
(R,S,R)-ML334 (Standard)
0 ImagesCat. No.: HY-110258BRCAS No.: 1432065-33-2Synonyms: (R,S,R)-LH601A (Standard)(R,S,R)-ML334 (Standard) is the analytical standard of (R,S,R)-ML334 (HY-110258B). This product is intended for research and analytical applications. (R,S,R)-ML334 is the isomer of ML334 (HY-110258), and can be used as an experimental control. ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a Kd of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity.
-
5-MeO-NBpBrT
0 ImagesCat. No.: HY-180495CAS No.: 155639-13-7Synonyms: 5MT-NB4B5-MeO-NBpBrT (Compound 2f) (5MT-NB4B) is a NBOMe derivative and 5MT-based N-(bromobenzyl) isomer.
