(+)-KF15232
(+)-KF15232 is a phosphodiesterase III/V inhibitor. (+)-KF15232 inhibits cAMP hydrolysis. (+)-KF15232 acts as a myofibrillar Ca2+ sensitizer. (+)-KF15232 can be used in research related to cardiovascular diseases.
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- CAS. Nr.: 174232-20-3
- Formel: C20H19N5O
- Molecular Weight:345.41
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
PDE Ⅲ |
PDE Ⅱ |
In Vitro
(+)-KF15232 relaxes guinea pig aortic rings precontracted with 10 µM PHE in a concentration-dependent manner[1].
(+)-KF15232 ((+)-1) (1-100 μM) exhibits the strongest myofibrillar Ca2+ sensitizing activity among the tested compounds in skinned guinea pig papillary muscle fibers[1].
(+)-KF15232 (10-30 min) inhibits bovine arterial PDE III and PDE V with IC50 values of 300 and 1000 nM, respectively, but does not inhibit canine cardiac PDE III at a concentration of 1000 nM, and also has no inhibitory effect on bovine arterial PDE IV (>10000 nM)[1].
(+)-KF15232 produces a concentration-dependent positive inotropic response in isolated guinea pig papillary muscles[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Hartley (Male, 460-570 g)[1]
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Dosage:0.01; 0.1; 1 mg/kg
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Administration:i.v.; increasing doses at 5-min intervals
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Result:Produced a dose-dependent increase in LV dP/dtmax at 0.01-1.0 mg/kg i.v.
Heart rate increased by less than 16% even at the maximum dose.
Chemical Information
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CAS. Nr. 174232-20-3
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Molecular Weight 345.41
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Formel C20H19N5O
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SMILES
N(CC1=CC=CC=C1)C=2C3=C(C=C(C=C3)C=4[C@@H](C)CC(=O)NN4)N=CN2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
(+)-KF15232 Related Classifications
HY-177110 Related Classifications
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