Altanserin hydrochloride
Based on 1 Customer Validation
Altanserin is a 5-hydroxytryptamine (5-HT2A ) selective radioligand. Altanserin delivers human serotonin. Altanserin can be used to study the biochemical and cellular mechanisms of vulnerability to extracellular 5-HT increase .
For research use only. We do not sell to patients.
- Purity : 99.73%
- CAS No.: 1135280-78-2
- Formula: C22H23ClFN3O2S
- Molecular Weight:447.95
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All 5-HT Receptor Isoforms
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Biological Activity
Description
IC50 & Target
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5-HT2A Receptor |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| U2OS | IC50 |
1.51 nM
Compound: Altanserin
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Antagonist activity at recombinant human 5-HT2A expressed in human U2OS cells by pathhunter beta-arrestin assay
Antagonist activity at recombinant human 5-HT2A expressed in human U2OS cells by pathhunter beta-arrestin assay
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[PMID: 32631554] |
Chemical Information
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CAS No. 1135280-78-2
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Appearance Solid
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Molecular Weight 447.95
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Formula C22H23ClFN3O2S
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SMILES
O=C1N(CCN2CCC(C(C3=CC=C(F)C=C3)=O)CC2)C(NC4=C1C=CC=C4)=S.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 25 mg/mL (55.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2324 mL | 11.1620 mL | 22.3239 mL | 55.8098 mL |
| 5 mM | 0.4465 mL | 2.2324 mL | 4.4648 mL | 11.1620 mL | |
| 10 mM | 0.2232 mL | 1.1162 mL | 2.2324 mL | 5.5810 mL | |
| 15 mM | 0.1488 mL | 0.7441 mL | 1.4883 mL | 3.7207 mL | |
| 20 mM | 0.1116 mL | 0.5581 mL | 1.1162 mL | 2.7905 mL | |
| 25 mM | 0.0893 mL | 0.4465 mL | 0.8930 mL | 2.2324 mL | |
| 30 mM | 0.0744 mL | 0.3721 mL | 0.7441 mL | 1.8603 mL | |
| 40 mM | 0.0558 mL | 0.2790 mL | 0.5581 mL | 1.3952 mL | |
| 50 mM | 0.0446 mL | 0.2232 mL | 0.4465 mL | 1.1162 mL |
Altanserin hydrochloride Related Classifications
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