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  3. Interleukin Related
  4. Anrukinzumab

Anrukinzumab  (Synonyms: IMA-638)

Cat. No.: HY-P99439 Purity: 98.64%
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Anrukinzumab (IMA-638) is a humanized anti-IL-13 monoclonal antibody. Anrukinzumab effectively reduces lung inflammation in a cynomolgus monkey model. Anrukinzumab can be used in studies of ulcerative colitis (UC) as well as asthma.

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CAS No. : 910649-32-0

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Based on 1 publication(s) in Google Scholar

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Description

Anrukinzumab (IMA-638) is a humanized anti-IL-13 monoclonal antibody. Anrukinzumab effectively reduces lung inflammation in a cynomolgus monkey model. Anrukinzumab can be used in studies of ulcerative colitis (UC) as well as asthma[1][2][3].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
IC50 & Target

IL-13[1][2][3].
In Vivo

Anrukinzumab (IMA-638; 10 mg/kg; intravenous infusion; single) reduces lung inflammation in cynomolgus monkey model of lung inflammation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male cynomolgus monkeys (6 to 10 kg; cynomolgus monkey model of lung inflammation)[1].
Dosage: 10 mg/kg
Administration: Intravenous infusion; single
Result: Reduced total BAL cell count, eosinophil number, and neutrophil number.
Reduced the levels of eotaxin and RANTES in BAL fluid.
Clinical Trial
Molecular Weight

145.38 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anrukinzumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation
References
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Anrukinzumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anrukinzumab910649-32-0IMA-638IMA638IMA 638Interleukin RelatedILUCasthmaBAL celleotaxinRANTESInhibitorinhibitorinhibit

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