2. Immunology/Inflammation
  3. Interleukin Related
  4. Anrukinzumab

Anrukinzumab  (Synonyms: IMA-638)

Cat. No.: HY-P99439

Anrukinzumab (IMA-638) is a humanized anti-IL-13 monoclonal antibody. Anrukinzumab effectively reduces lung inflammation in a cynomolgus monkey model. Anrukinzumab can be used in studies of ulcerative colitis (UC) as well as asthma.

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Anrukinzumab Chemical Structure

Anrukinzumab Chemical Structure

CAS No. : 910649-32-0

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Description

Anrukinzumab (IMA-638) is a humanized anti-IL-13 monoclonal antibody. Anrukinzumab effectively reduces lung inflammation in a cynomolgus monkey model. Anrukinzumab can be used in studies of ulcerative colitis (UC) as well as asthma[1][2][3].

IC50 & Target

IL-13[1][2][3].
In Vivo

Anrukinzumab (IMA-638; 10 mg/kg; intravenous infusion; single) reduces lung inflammation in cynomolgus monkey model of lung inflammation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male cynomolgus monkeys (6 to 10 kg; cynomolgus monkey model of lung inflammation)[1].
Dosage: 10 mg/kg
Administration: Intravenous infusion; single
Result: Reduced total BAL cell count, eosinophil number, and neutrophil number.
Reduced the levels of eotaxin and RANTES in BAL fluid.
CAS No.
SMILES

[Anrukinzumab]
Storage

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Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Anrukinzumab910649-32-0IMA-638IMA638IMA 638Interleukin RelatedILUCasthmaBAL celleotaxinRANTESInhibitorinhibitorinhibit

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