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Cat. No.: HY-116904

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Anticancer agent 253

Anticancer agent 253 (Compound 26) has anti-cancer activity against breast cancer cells, with IC₅₀s of 6 μM (MCF-7), 10 μM (MDA-MB-231) and 6.4 μM (4T1 cells). Anticancer agent 253 arrests cell cycle and induces mitochondria-mediated apoptosis in cancer cells. Anticancer agent 253 inhibits Akt phosphorylation in human breast and prostate cancer.

For research use only. We do not sell to patients.

CAS No.: 1983924-33-9
Formula: C₂₉H₂₃F₃N₄O
Molecular Weight:500.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Anticancer agent 253 Chemical Structure

CAS No.: 1983924-33-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All Akt Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
4T1	IC₅₀	6.4 μM Compound: 26	Cytotoxicity against mouse 4T1 cells assessed as decrease in cell viability after 24 hrs by MTT assay Cytotoxicity against mouse 4T1 cells assessed as decrease in cell viability after 24 hrs by MTT assay	[PMID: 27496212]
DU-145	IC₅₀	8.7 μM Compound: 26	Cytotoxicity against human DU145 cells assessed as decrease in cell viability after 24 hrs by MTT assay Cytotoxicity against human DU145 cells assessed as decrease in cell viability after 24 hrs by MTT assay	[PMID: 27496212]
HEK293	IC₅₀	46 μM Compound: 26	Cytotoxicity against human HEK293 cells assessed as decrease in cell viability after 24 hrs by MTT assay Cytotoxicity against human HEK293 cells assessed as decrease in cell viability after 24 hrs by MTT assay	[PMID: 27496212]
LA7	IC₅₀	3.1 μM Compound: 12; CT-1	Antiproliferative activity against rat LA7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against rat LA7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 36893627]
MCF7	IC₅₀	2.1 μM Compound: 12; CT-1	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 36893627]
MCF7	IC₅₀	6 μM Compound: 26	Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 24 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 24 hrs by MTT assay	[PMID: 27496212]
MDA-MB-231	IC₅₀	10 μM Compound: 26	Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell viability after 24 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell viability after 24 hrs by MTT assay	[PMID: 27496212]
PC-3	IC₅₀	19.4 μM Compound: 26	Cytotoxicity against human PC3 cells assessed as decrease in cell viability after 24 hrs by MTT assay Cytotoxicity against human PC3 cells assessed as decrease in cell viability after 24 hrs by MTT assay	[PMID: 27496212]

Chemical Information

CAS No. 1983924-33-9
Molecular Weight 500.51
Formula C₂₉H₂₃F₃N₄O
SMILES

O=C(/C(CN(C/1)CC2=CN(N=N2)CC3=CC=C(C=C3)F)=C/C4=C(C=CC=C4)F)C1=C\C5=C(C=CC=C5)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mandalapu D, et al. Synthesis and biological evaluation of some novel triazole hybrids of curcumin mimics and their selective anticancer activity against breast and prostate cancer cell lines. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4223-32. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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