Art. -Nr.: HY-111770

2-Bromohexadecanoic acid

(Synonyms: 2-Bromopalmitic acid; 2-Bromopalmitate)

20 Cited Publications

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Based on 20 publication(s) in Google Scholar

2-Bromohexadecanoic acid (2-Bromopalmitate; 2-BP) is a palmitoylation inhibitor targeting DHHC (Asp-His-His-Cys) protein palmitoyltransferase. 2-Bromohexadecanoic acid inhibits palmitoylation of GSDME-C during pyroptosis and inhibits BAK/BAX-Caspase 3-GSDME pathway-mediated pyroptosis.

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Reinheit: 99.95%
CAS. Nr.: 18263-25-7
Formel: C₁₆H₃₁BrO₂
Molecular Weight:335.32

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

2-Bromohexadecanoic acid Chemical Structure

CAS. Nr.: 18263-25-7

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Publications (20)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Palmitoylation promotes the release of GSDME-C from GSDME-N after cleavage, and 2-BP inhibits the palmitoylation process, while inhibiting the modification of GSDME-C increases the interaction between GSDME-C and GSDME-N. 2-BP inhibits TNFa+CHX-induced apoptosis but not total cell death^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 18263-25-7
Appearance Solid
Molecular Weight 335.32
Formel C₁₆H₃₁BrO₂
Color White to yellow
SMILES

CCCCCCCCCCCCCCC(Br)C(O)=O
Synonyms

2-Bromopalmitic acid; 2-Bromopalmitate
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (20)

All WBCell Proliferation/Viability AssayCell Imaging/StainingIF

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Journal Impact Factor

Science

STING-NF-κB signaling builds an influenza spillover barrier. [Abstract]

2026 Feb 26;391(6788):eads4405. PMID: 41747053
Cell Metab

Lipid droplet-induced T cell death sustains autoimmune tissue inflammation. [Abstract]

2026 Feb 18:S1550-4131(26)00015-X. PMID: 41713424
ACS Nano

Mechanism of S-Palmitoylation in Polystyrene Nanoplastics-Induced Macrophage Cuproptosis Contributing to Emphysema through Alveolar Epithelial Cell Pyroptosis. [Abstract]

2025 May 20;19(19):18708-18728. PMID: 40335889
Adv Sci (Weinh)

SMAD4 Palmitoylation Drives a Metabolic-Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer. [Abstract]

2026 Mar 26:e19791. PMID: 41885390
Adv Sci (Weinh)

Iron Overload Mediates the Differential Cell Fate of Astrocytes from Neurons and Its Regulatory Mechanisms in Ischemic Stroke. [Abstract]

2025 Nov 6:e07384. PMID: 41195589

2-Bromohexadecanoic acid purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Nov 6:e07384. [Abstract]

HA cells were cultured with 10 µM 2‐BP during reoxygenation for 24 h. Western blot results showed a significant reduction in total TfR1 levels and total TfR1 palmitoylation levels.

2-Bromohexadecanoic acid purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Nov 6:e07384. [Abstract]

Confocal microscopy images visually demonstrate the palmitoylation of TfR1 and its changes in localization on the cell membrane after treatment with OGD/Re and 2-BP (10 μM, 24 h).

2-Bromohexadecanoic acid purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Nov 6:e07384. [Abstract]

Immunofluorescence results showed that OGD/Re treatment increased the co-localization of TfR1 and clathrin in HA cells, while 2-BP (10 μM, 24 h) decreased their co-localization.
Theranostics

Oxidative stress-mediated PANoptosis and ferroptosis: Exploration of multimodal cell death triggered by an AIE-active nano-photosensitizer via photodynamic therapy. [Abstract]

2025 Jun 9;15(14):6665-6685. PMID: 40585993

2-Bromohexadecanoic acid purchased from MedChemExpress. Usage Cited in: Theranostics. 2025 Jun 9;15(14):6665-6685. [Abstract]

A2058 and MHCC 97H cells were treated with T-T NPs, and cell viability was assessed with or without light using 2-bromohexadecanoic acid (5 µM, 3 h).
Cell Discov

ASCT2 palmitoylation regulated by JNK1-ZDHHC14 axis orchestrates glutamine metabolism and NSCLC progression. [Abstract]

2026 Feb 24;12(1):13. PMID: 41730846
J Biomed Sci

PEX11B palmitoylation couples peroxisomal dysfunction with Schwann cells fail in diabetic neuropathy. [Abstract]

2025 Feb 12;32(1):20. PMID: 39934809

2-Bromohexadecanoic acid purchased from MedChemExpress. Usage Cited in: J Biomed Sci. 2025 Feb 12;32(1):20. [Abstract]

Western blot detection of peroxisomes-related proteins under PA (400 μM) and PA (400 μM) with 2-BP (50 μM) conditions for 24 h in RSC96 cells. Tubulin was used as a loading control.

2-Bromohexadecanoic acid purchased from MedChemExpress. Usage Cited in: J Biomed Sci. 2025 Feb 12;32(1):20. [Abstract]

Representative immunofluorescence staining for PMP70 (green) under PA (400 μM) and PA (400 μM) with 2-BP (50 μM) conditions for 24 h in RSC96 cells.
Research (Wash D C)

EVA1A Regulates Hepatic Lipid Homeostasis by Modulating CD36 Expression and Its Palmitoylation. [Abstract]

2025 Nov 25:8:1001. PMID: 41306774
Cell Mol Biol Lett

The histone demethylase KDM5C enhances the sensitivity of acute myeloid leukemia cells to lenalidomide by stabilizing cereblon. [Abstract]

2025 Jan 29;30(1):14. PMID: 39881283
Cancer Lett

Succinate dehydrogenase B palmitoylation promotes T cell exhaustion through the H3K27ac-PD1 axis in pancreatic cancer. [Abstract]

2026 Apr 1:642:218277. PMID: 41577075
Cell Death Dis

ZDHHC9 palmitoylates LAMTOR1 to promote renal cell carcinoma malignant progression. [Abstract]

2026 Mar 19;17(1):323. PMID: 41856969
Acta Neuropathol

Fyn-dependent Tau microcluster formation seeds and boosts extensive Tau pathology. [Abstract]

2025 May 14;149(1):48. PMID: 40366450
Phytomedicine

Columbianadin targets TRIM7 to maintain P2X7 palmitoylation, inhibiting cuproptosis in synovial M2 macrophages. [Abstract]

2025 Oct:146:157091. PMID: 40768810
Ecotoxicol Environ Saf

Arsenic exposure provoked prostatic PANoptosis by inducing mitochondrial dysfunction in mice and WPMY-1 cells. [Abstract]

2025 Apr 3:295:118139. PMID: 40185034
Cancer Biol Ther

Lenvatinib promotes hepatocellular carcinoma pyroptosis by regulating GSDME palmitoylation. [Abstract]

2025 Dec;26(1):2532217. PMID: 40653759
J Virol

Fatty Acid Synthase Is Involved in Classical Swine Fever Virus Replication by Interaction with NS4B. [Abstract]

2021 Aug 10;95(17):e0078121. PMID: 34132567
Vet Microbiol

Lipid metabolism is a novel and practical source of potential targets for antiviral discovery against porcine parvovirus. [Abstract]

2021 Oct:261:109177. PMID: 34391196
Biochim Biophys Acta Proteins Proteom

Phafin2 modulates the aggregation of NLRP3 on dispersed trans-Golgi network. [Abstract]

2025 Oct 13;1874(1):141101. PMID: 41093223
SSRN

2025 Sep 17.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 125 mg/mL (372.78 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.9822 mL

14.9111 mL

29.8223 mL

5 mM

0.5964 mL

2.9822 mL

5.9645 mL

10 mM

0.2982 mL

1.4911 mL

2.9822 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (7.46 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (7.46 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 0.5% CMC-Na/saline water

Solubility: 5 mg/mL (14.91 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Hu L, et al. Chemotherapy-induced pyroptosis is mediated by BAK/BAX-caspase-3-GSDME pathway and inhibited by 2-bromopalmitate. Cell Death Dis. 2020 Apr 24;11(4):281. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.9822 mL	14.9111 mL	29.8223 mL	74.5556 mL
	5 mM	0.5964 mL	2.9822 mL	5.9645 mL	14.9111 mL
	10 mM	0.2982 mL	1.4911 mL	2.9822 mL	7.4556 mL
	15 mM	0.1988 mL	0.9941 mL	1.9882 mL	4.9704 mL
	20 mM	0.1491 mL	0.7456 mL	1.4911 mL	3.7278 mL
	25 mM	0.1193 mL	0.5964 mL	1.1929 mL	2.9822 mL
	30 mM	0.0994 mL	0.4970 mL	0.9941 mL	2.4852 mL
	40 mM	0.0746 mL	0.3728 mL	0.7456 mL	1.8639 mL
	50 mM	0.0596 mL	0.2982 mL	0.5964 mL	1.4911 mL
	60 mM	0.0497 mL	0.2485 mL	0.4970 mL	1.2426 mL
	80 mM	0.0373 mL	0.1864 mL	0.3728 mL	0.9319 mL
	100 mM	0.0298 mL	0.1491 mL	0.2982 mL	0.7456 mL

Keywords

2-Bromohexadecanoic acid

20 Cited Publications

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2-Bromohexadecanoic acid

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Publications Citing Use of MedChemExpress (MCE) 2-Bromohexadecanoic acid

Biologische Aktivität

Chemical Information

Publications (20)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

2-Bromohexadecanoic acid

Anti-Infection Compound Library

Immunology/Inflammation Compound Library

Anti-Cancer Compound Library

Mitochondrial Toxicity Compound Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) 2-Bromohexadecanoic acid

Biologische Aktivität

Chemical Information

Publications (20)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

2-Bromohexadecanoic acid Related Classifications

Art. -Nr.: HY-111770