447C88
447C88 is an acyl-coenzyme A cholesterol acyltransferase (ACAT) inhibitor with an IC50 of 23 nM. 447C88 can reduce plasma cholesterol levels and can be used in the research of endocrine and metabolic diseases such as hyperlipidemia.
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- CAS. Nr.: 130400-16-7
- Formel: C27H38F2N2O
- Molecular Weight:444.60
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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ACAT 23 nM (IC50) |
Chemical Information
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CAS. Nr. 130400-16-7
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Molecular Weight 444.60
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Formel C27H38F2N2O
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SMILES
O=C(NCCCCCCC)NC1=C(F)C=C(F)C=C1CCC2=CC=C(CC(C)(C)C)C=C2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Fraser IJ, et al. Determination of the acylcoenzyme A cholesterol acyltransferase inhibitor 447C88 in plasma using gas chromatography-mass spectrometry and liquid chromatography atmospheric pressure chemical ionisation tandem mass spectrometry. J Chromatogr B Biomed Appl. 1995 Jan 20;663(2):275-87. [Content Brief]
[2]. Peck RW, et al. The tolerability, pharmacokinetics and lack of effect on plasma cholesterol of 447C88, an AcylCoA: Cholesterol Acyl Transferase (ACAT) inhibitor with low bioavailability, in healthy volunteers. Eur J Clin Pharmacol. 1995;49(3):243-9. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
447C88 Related Classifications
HY-19112 Related Classifications
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