Art. -Nr.: HY-106660

BP 897 hydrochloride

Name: BP 897 hydrochloride
Brand: MedChemExpress
SKU: HY-106660
Price: 40.00 USD
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BP 897 hydrochloride is a potent and partial dopamine D3 receptor agonist and a weak D2 receptor antagonist. BP 897 hydrochloride displays a high affinity at the dopamine D3 receptor (K_i=0.92 nM) and a 70 times lower affinity at the D2 receptor (K_i=61 nM).

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Reinheit : 99.60%
CAS. Nr.: 314776-92-6
Formel: C₂₆H₃₂ClN₃O₂
Molecular Weight:454.00

Speicherung:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

BP 897 hydrochloride Chemical Structure

CAS. Nr.: 314776-92-6

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

D₂ Receptor

D₃ Receptor

Alle Dopamine Receptor Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	CC₅₀	30.03 μM Compound: BP-897	Toxicity against Caco-2 cells determined at 48 hours by intracellular ATP concentration using the CellTiter-Glo Luminescent Cell Viability Assay Toxicity against Caco-2 cells determined at 48 hours by intracellular ATP concentration using the CellTiter-Glo Luminescent Cell Viability Assay	10.21203/rs.3.rs-23951/v1
Caco-2	IC₅₀	18.95 μM Compound: BP-897	Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells after 48 hours by high content imaging Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells after 48 hours by high content imaging	10.21203/rs.3.rs-23951/v1
CHO	EC₅₀	2.7 nM Compound: BP897	Effective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptor Effective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptor	[PMID: 15916420]
COS-7	IC₅₀	0.41 nM Compound: BP897	Displacement of [3H]nemonapride from Rattus norvegicus (rat) wild type dopamine D3 receptor transfected in african green monkey COS7 cells after 1 hr by beta scintillation counting Displacement of [3H]nemonapride from Rattus norvegicus (rat) wild type dopamine D3 receptor transfected in african green monkey COS7 cells after 1 hr by beta scintillation counting	10.1007/s00044-004-0006-x
COS-7	IC₅₀	0.72 nM Compound: BP897	Displacement of [3H]nemonapride from Rattus norvegicus (rat) chimeric dopamine D3 trunk/D3 tail receptor transfected in african green monkey COS7 cells after 1 hr by beta scintillation counting Displacement of [3H]nemonapride from Rattus norvegicus (rat) chimeric dopamine D3 trunk/D3 tail receptor transfected in african green monkey COS7 cells after 1 hr by beta scintillation counting	10.1007/s00044-004-0006-x
COS-7	IC₅₀	1.02 nM Compound: BP897	Displacement of [3H]nemonapride from Rattus norvegicus (rat) chimeric dopamine D3 trunk/D2 tail receptor transfected in african green monkey COS7 cells after 1 hr by beta scintillation counting Displacement of [3H]nemonapride from Rattus norvegicus (rat) chimeric dopamine D3 trunk/D2 tail receptor transfected in african green monkey COS7 cells after 1 hr by beta scintillation counting	10.1007/s00044-004-0006-x
COS-7	IC₅₀	24.2 nM Compound: BP897	Displacement of [3H]nemonapride from Rattus norvegicus (rat) wild type dopamine D2 receptor transfected in african green monkey COS7 cells after 1 hr by beta scintillation counting Displacement of [3H]nemonapride from Rattus norvegicus (rat) wild type dopamine D2 receptor transfected in african green monkey COS7 cells after 1 hr by beta scintillation counting	10.1007/s00044-004-0006-x
COS-7	IC₅₀	27.5 nM Compound: BP897	Displacement of [3H]nemonapride from Rattus norvegicus (rat) chimeric dopamine D2 trunk/D3 tail receptor transfected in african green monkey COS7 cells after 1 hr by beta scintillation counting Displacement of [3H]nemonapride from Rattus norvegicus (rat) chimeric dopamine D2 trunk/D3 tail receptor transfected in african green monkey COS7 cells after 1 hr by beta scintillation counting	10.1007/s00044-004-0006-x
COS-7	IC₅₀	28.3 nM Compound: BP897	Displacement of [3H]nemonapride from Rattus norvegicus (rat) chimeric dopamine D2 trunk/D2 tail receptor transfected in african green monkey COS7 cells after 1 hr by beta scintillation counting Displacement of [3H]nemonapride from Rattus norvegicus (rat) chimeric dopamine D2 trunk/D2 tail receptor transfected in african green monkey COS7 cells after 1 hr by beta scintillation counting	10.1007/s00044-004-0006-x
U2OS	IC₅₀	13 nM Compound: 6, BP 897	Antagonist activity at human dopamine D3 receptor expressed in human U2OS cells assessed as inhibition of pramipexole-stimulated beta-arrestin recruitment Antagonist activity at human dopamine D3 receptor expressed in human U2OS cells assessed as inhibition of pramipexole-stimulated beta-arrestin recruitment	[PMID: 24848155]
U2OS	ED₅₀	>100000 nM Compound: 6, BP 897	Agonist activity at human dopamine D3 receptor expressed in human U2OS cells assessed as stimulation of beta-arrestin recruitment Agonist activity at human dopamine D3 receptor expressed in human U2OS cells assessed as stimulation of beta-arrestin recruitment	[PMID: 24848155]

In Vitro

BP 897 hydrochloride also displays low affinities at D1 and D4 receptors (K_i=3 and 0.3 μM, respectively), as well as at α1 and α2 adrenergic receptors (K_i=60 and 83 nM, respectively), 5HT1A and 5HT7 receptors (K_i=84 and 345 nM, respectively), and negligible affinities (K_i>1 μM) atmuscarinic, histamine and opiate receptors^[1].
In NG 108-15 cells expressing the human D3 receptor, BP 897 hydrochloride inhibits forskolin-induced cyclic AMP accumulation with an EC₅₀ of 1 nM. BP 897 hydrochloride activates mitogenesis and this response is antagonized by the preferential D3 receptor antagonist Nafadotride (1 μM). BP 897 hydrochloride also partially antagonized the response induced by quinpirole (10 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

BP 897 hydrochloride binds to D2-receptor in mouse striatum with an ED₅₀ of 15 mg/kg, and the D3-receptor occupancy is blow 0.5 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Listar hooded rats^[1]
Dosage:

0.05, 0.5, 1 mg/kg
Administration:

i.p.; 30 min before the session
Result:

Reduced cocaine-seeking behaviour before the first infusion of cocaine, in a dose-dependent manner, at doses similar to those at which BP 897 produced its responses on rotations and c-fos expression.

Chemical Information

CAS. Nr. 314776-92-6
Appearance Solid
Molecular Weight 454.00
Formel C₂₆H₃₂ClN₃O₂
Color White to off-white
SMILES

COC1=C(N2CCN(CCCCNC(C3=CC4=C(C=CC=C4)C=C3)=O)CC2)C=CC=C1.[H]Cl
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 125 mg/mL (275.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2026 mL

11.0132 mL

22.0264 mL

5 mM

0.4405 mL

2.2026 mL

4.4053 mL

10 mM

0.2203 mL

1.1013 mL

2.2026 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Pilla M, et al. Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist. Nature. 1999 Jul 22;400(6742):371-5. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2026 mL	11.0132 mL	22.0264 mL	55.0661 mL
	5 mM	0.4405 mL	2.2026 mL	4.4053 mL	11.0132 mL
	10 mM	0.2203 mL	1.1013 mL	2.2026 mL	5.5066 mL
	15 mM	0.1468 mL	0.7342 mL	1.4684 mL	3.6711 mL
	20 mM	0.1101 mL	0.5507 mL	1.1013 mL	2.7533 mL
	25 mM	0.0881 mL	0.4405 mL	0.8811 mL	2.2026 mL
	30 mM	0.0734 mL	0.3671 mL	0.7342 mL	1.8355 mL
	40 mM	0.0551 mL	0.2753 mL	0.5507 mL	1.3767 mL
	50 mM	0.0441 mL	0.2203 mL	0.4405 mL	1.1013 mL
	60 mM	0.0367 mL	0.1836 mL	0.3671 mL	0.9178 mL
	80 mM	0.0275 mL	0.1377 mL	0.2753 mL	0.6883 mL
	100 mM	0.0220 mL	0.1101 mL	0.2203 mL	0.5507 mL

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BP 897 hydrochloride

Alle Dopamine Receptor Isoform-spezifische Produkte anzeigen