Art. -Nr.: HY-B0998

Dehydrocholic acid sodium

(Synonyms: Dehydrocholate sodium)

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Dehydrocholic acid (Dehydrocholate) sodium is an orally active hydrocholeretic agent. Dehydrocholic acid sodium modulates Autophagy, reduces serum amylase and lipase levels. Dehydrocholic acid sodium has the effects of promoting choleretic function, protecting the liver, reducing pancreatic damage, and regulating cholesterol metabolism. Dehydrocholic acid sodium can be used in the study of acute biliary pancreatitis and obstructive jaundice.

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Reinheit: 99.38%
CAS. Nr.: 145-41-5
Formel: C₂₄H₃₃NaO₅
Molecular Weight:424.51

Speicherung:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Dehydrocholic acid sodium Chemical Structure

CAS. Nr.: 145-41-5

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Dehydrocholic acid sodium (Dehydrocholic acid; 50-200 μM; 50 min) reduces the necrosis of pancreatic acinar cells induced by sodium Taurocholate (HY-N0545)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Dehydrocholic acid sodium (Dehydrocholic acid; 25-50 mg/kg; i.p.; 1, 3 and 6 h after the surgery for 3 times) alleviates the severity of Sodium taurocholate-induced acute biliary pancreatitis in C57BL/6 mice, reducing pancreatic histopathological alterations, serum amylase and lipase levels, and suppressing pancreatic trypsin and MPO activities^[1].
Dehydrocholate sodium (1-4 μmol/min/100g BW; intravenous infusion) increases bile flow and reduces the secretion of endogenous and exogenous biliary bile acids and biliary lipids in rats^[2].
Dehydrocholate sodium (Dehydrocholic acid; 100 mg/kg; p.o. via water bottles) shows choleretic and mild hepatoprotective effects in albino rats with obstructive jaundice^[3].
Dehydrocholate sodium (0.4% in diet; p.o.; 1 week) increases liver cholesterol level, bile flow and biliary lipid secretion in rats, and its biological effect is similar to that of cholate^[4].
Dehydrocholate sodium (50 mg/kg initial dose, then 167 mg/kg/hr infusion; i.v. and infusion) increases bile flow but does not affect the biliary excretion of methylmercury in rats^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Albino rats (100-150 g), obstructive jaundice model induced by ligating the common bile ducts^[3]
Dosage:

100 mg/kg
Administration:

Oral gavage (p.o.), via water bottles
Result:

Led to more marked bile duct dilatation compared to the control group.
Had a choleretic effect, increasing bile volume.
Showed milder liver damage compared to the control group, with marked sinusoidal dilatation and scattered bile lakes.
Had some degree of hepatocyte vacuolation at 4-5 weeks after ligation.

Chemical Information

CAS. Nr. 145-41-5
Appearance Solid
Molecular Weight 424.51
Formel C₂₄H₃₃NaO₅
Color White to off-white
SMILES

C[C@H](CCC(O[Na])=O)[C@H]([C@]12C)CC[C@@]1([H])[C@]3([H])C(C[C@]4([H])CC(CC[C@]4(C)[C@@]3([H])CC2=O)=O)=O
Synonyms

Dehydrocholate sodium
Structure Classification
- Steroids
Initial Source
- Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (235.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 50 mg/mL (117.78 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3557 mL

11.7783 mL

23.5566 mL

5 mM

0.4711 mL

2.3557 mL

4.7113 mL

10 mM

0.2356 mL

1.1778 mL

2.3557 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (5.89 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (5.89 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (5.89 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 33.33 mg/mL (78.51 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (252 KB)
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COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhang X, et al. Dehydrocholic Acid Ameliorates Sodium Taurocholate-Induced Acute Biliary Pancreatitis in Mice. Biol Pharm Bull. 2020;43(6):985-993. [Content Brief]

[2]. Yousef IM, et al. Influence of dehydrocholic acid on the secretion of bile acids and biliary lipids in rats. Digestion. 1990;45(1):40-51. [Content Brief]

[3]. Ratan J, et al. A controlled trial of choleretic and hepatoprotective actions of Livzon and dehydrocholic acid in a model of obstructive jaundice in albino rats. Tohoku J Exp Med. 1997 Jan;181(1):161-6. [Content Brief]

[4]. UCHIDA K, et al. EFFECTS OF SODIUM URSODEOXYCHOLATE, HYODEOXY-CHOLATE AND DEHYDROCHOLATE ON CHOLESTEROL AND BILE ACID METABOLISM IN RATS. Journal of Pharmacobio-Dynamics, 1983, 6(5): 346-357.

[5]. Magos L, et al. The effect of phenobarbital and sodium dehydrocholate on the biliary excretion of methylmercury in the rat. Toxicology and Applied Pharmacology, 1974, 30(1): 1-6.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	2.3557 mL	11.7783 mL	23.5566 mL	58.8914 mL
	5 mM	0.4711 mL	2.3557 mL	4.7113 mL	11.7783 mL
	10 mM	0.2356 mL	1.1778 mL	2.3557 mL	5.8891 mL
	15 mM	0.1570 mL	0.7852 mL	1.5704 mL	3.9261 mL
	20 mM	0.1178 mL	0.5889 mL	1.1778 mL	2.9446 mL
	25 mM	0.0942 mL	0.4711 mL	0.9423 mL	2.3557 mL
	30 mM	0.0785 mL	0.3926 mL	0.7852 mL	1.9630 mL
	40 mM	0.0589 mL	0.2945 mL	0.5889 mL	1.4723 mL
	50 mM	0.0471 mL	0.2356 mL	0.4711 mL	1.1778 mL
	60 mM	0.0393 mL	0.1963 mL	0.3926 mL	0.9815 mL
	80 mM	0.0294 mL	0.1472 mL	0.2945 mL	0.7361 mL
	100 mM	0.0236 mL	0.1178 mL	0.2356 mL	0.5889 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dehydrocholic acid sodium

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Biologische Aktivität

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Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Dehydrocholic acid sodium

Metabolism/Protease Compound Library

Natural Product Library

Autophagy Compound Library

Orally Active Compound Library

FDA Approved & Pharmacopeial Drug Library

Metabolic Enzyme Compound Library

Cysteine Targeted Covalent Library

Cell Death Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Natural Product Diversity Scaffold Library

Mass Spectrometry Natural Product Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Dehydrocholic acid sodium Related Classifications

HY-B0998 Related Classifications