Art. -Nr.: HY-B0412

Estriol

(Synonyms: Oestriol)

7 Cited Publications

Kundenbewertung

Based on 7 publication(s) in Google Scholar

Estriol (Oestriol), an orally active estrogen, is a ERα and ERβ agonist. Estriol is a potent GPR30 antagonist in estrogen receptor-negative breast cancer cells. Estriol can ameliorate disease severity through immunomodulatory mechanisms that decrease tissue inflammation. Estriol has powerful proconvulsant effects.

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Reinheit: 98.05%
CAS. Nr.: 50-27-1
Formel: C₁₈H₂₄O₃
Molecular Weight:288.39

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Estriol Chemical Structure

CAS. Nr.: 50-27-1

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (7)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Human Endogenous Metabolite

Alle Estrogen Receptor/ERR Isoform-spezifische Produkte anzeigen :

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	EC₅₀	4.83 M Compound: 34	Growth response in cultures of MCF-7 (human breast cancer cell line) cells Growth response in cultures of MCF-7 (human breast cancer cell line) cells	[PMID: 9357533]
MCF7	EC₅₀	4.83 x 10^-9M Compound: 34	Growth response in cultures of MCF-7 (human breast cancer cell line) cells Growth response in cultures of MCF-7 (human breast cancer cell line) cells	[PMID: 9357533]

In Vitro

Estriol (Oestriol) binds to both ER and GPR30, however it can exhibit ER agonism or GPR30 antagonism depending on the receptor expression profile in the different cancer cell contexts^[1].
Estriol (1-80 μM; for 7 days) reduces cell number of 17β-estradiol stimulated HCC1806 cells very clearly down to 16% at 80 μM^[2].
Estriol (100 μM; pretreated for 30 minutes) completely prevented activation of cyclin D1 expression by 17β-estradiol^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

GPR30 positive (HCC1806) and a GPR30 negative TNBC cell line (MDA-MB-231)
Concentration:

1, 10, 20, 40, 60, 80 μM
Incubation Time:

For 7 days
Result:

Reduced cell number of 17β-estradiol stimulated HCC1806 cells very clearly down to 16±12% (p < 0.01) at 80 μM whereas in MDA-MB-231 cells was reduced to only 61±10% at the highest applied concentration.

Cell Cycle Analysis^[2]

Cell Line:

HCC1806 cells
Concentration:

100 μM
Incubation Time:

Pretreated for 30 minutes
Result:

Completely prevented activation of cyclin D1 expression by 17β-estradiol (10 nM; 10 min or 20 minutes).

In Vivo

Estriol (Oestriol ; 0.005, 0.01 mg/kg; IP; daily; for 5 weeks) enhances the percentage incidence of seizures^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Swiss Albino mice weighing between 25 and 35 g^[3]
Dosage:

0.005, 0.01 mg/kg
Administration:

IP; daily; for 5 weeks
Result:

Reduced the time for induction of kindling from 5 weeks to 3 and 2 weeks for male and female mice respectively and enhanced the percentage incidence of seizures.

Chemical Information

CAS. Nr. 50-27-1
Appearance Solid
Molecular Weight 288.39
Formel C₁₈H₂₄O₃
Color White to off-white
SMILES

C[C@@]1([C@H]2O)[C@](C[C@H]2O)([H])[C@@](CCC3=C4C=CC(O)=C3)([H])[C@]4([H])CC1
Synonyms

Oestriol
Structure Classification
- Phenols
- Monophenols
- Steroids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (7)

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Journal Impact Factor

Cell Metab

Sensing steroid hormone 17α-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury. [Abstract]

2024 Nov 5;36(11):2402-2418.e10. PMID: 39389061
Nat Chem Biol

Structures of the ADGRG2-Gs complex in apo and ligand-bound forms. [Abstract]

2022 Nov;18(11):1196-1203. PMID: 35982227
Biosens Bioelectron

Split aptamer regulated CRISPR/Cas12a biosensor for 17β-estradiol through a gap-enhanced Raman tags based lateral ﬂow strategy. [Abstract]

2022 Nov 1:215:114548. PMID: 35870335
Proc Natl Acad Sci U S A

Progesterone activates GPR126 to promote breast cancer development via the Gi pathway. [Abstract]

2022 Apr 12;119(15):e2117004119. PMID: 35394864
Anal Chem

High-Throughput Reactive Desorption Electrospray Ionization Mass Spectrometry for Targeted Derivatization and Analysis of Poorly Ionized Small Molecules. [Abstract]

2026 Jun 16;98(23):16962-16970. PMID: 42223360
Aquat Toxicol

Mestranol induces a reversible lysosomal storage-like state in zebrafish microglia. [Abstract]

2026 Jun 2:298:107880. PMID: 42251851
J Cell Mol Med

Pharmacological Targeting of DHHC9-Mediated STRN4 Palmitoylation to Suppress YAP-Driven Cancer Metastasis. [Abstract]

2025 Sep;29(17):e70815. PMID: 40903842

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 250 mg/mL (866.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.4675 mL

17.3376 mL

34.6753 mL

5 mM

0.6935 mL

3.4675 mL

6.9351 mL

10 mM

0.3468 mL

1.7338 mL

3.4675 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (7.21 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (7.21 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (7.21 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Rosamaria Lappano, et al. Estriol acts as a GPR30 antagonist in estrogen receptor-negative breast cancer cells. Mol Cell Endocrinol. 2010 May 14;320(1-2):162-70. [Content Brief]

[2]. Rainer Girgert, et al. Inhibition of GPR30 by estriol prevents growth stimulation of triple-negative breast cancer cells by 17β-estradiol. BMC Cancer. 2014 Dec 11:14:935. [Content Brief]

[3]. Aakifa Ahmad, et al. Proconvulsant effects of estriol, the third estrogen, in the mouse PTZ-kindling model. Neurol Sci. 2014 Oct;35(10):1561-6. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.4675 mL	17.3376 mL	34.6753 mL	86.6882 mL
	5 mM	0.6935 mL	3.4675 mL	6.9351 mL	17.3376 mL
	10 mM	0.3468 mL	1.7338 mL	3.4675 mL	8.6688 mL
	15 mM	0.2312 mL	1.1558 mL	2.3117 mL	5.7792 mL
	20 mM	0.1734 mL	0.8669 mL	1.7338 mL	4.3344 mL
	25 mM	0.1387 mL	0.6935 mL	1.3870 mL	3.4675 mL
	30 mM	0.1156 mL	0.5779 mL	1.1558 mL	2.8896 mL
	40 mM	0.0867 mL	0.4334 mL	0.8669 mL	2.1672 mL
	50 mM	0.0694 mL	0.3468 mL	0.6935 mL	1.7338 mL
	60 mM	0.0578 mL	0.2890 mL	0.5779 mL	1.4448 mL
	80 mM	0.0433 mL	0.2167 mL	0.4334 mL	1.0836 mL
	100 mM	0.0347 mL	0.1734 mL	0.3468 mL	0.8669 mL

Keywords

Estriol

7 Cited Publications

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Estriol

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Publications Citing Use of MedChemExpress (MCE) Estriol

Alle Estrogen Receptor/ERR Isoform-spezifische Produkte anzeigen

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (7)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Estriol Related Classifications

HY-B0412 Related Classifications