Ibotenic acid
Based on 7 publication(s) in Google Scholar
Ibotenic acid has agonist activity at both the N-methyl-D-aspartate (NMDA) and trans-ACPD or metabolotropic quisqualate (Qm) receptor sites.
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- Reinheit: 99.34%
- CAS. Nr.: 2552-55-8
- Formel: C5H6N2O4
- Molecular Weight:158.11
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Chemical Information
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Lösungsmittel & Löslichkeit
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Publications Citing Use of MedChemExpress (MCE) Ibotenic acid
More- Fundam Res. 2023 Jan 3;4(4):829-840. [Abstract]
- CNS Neurosci Ther. 2024 Aug;30(8):e14922. [Abstract]
- CNS Neurosci Ther. 2024 Jun;30(6):e14782. [Abstract]
- CNS Neurosci Ther. 2024 Feb;30(2):e14611. [Abstract]
- J Physiol. 2024 Aug;602(15):3755-3768. [Abstract]
- Brain Res Bull. 2022 Jul;185:18-27. [Abstract]
- Neurosci Lett. 2024 Apr 1:828:137753. [Abstract]
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Biologische Aktivität
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NMDA Receptor |
Ibotenic acid (Ibo) is capable of acting at both NMDA and trans-ACPD receptors in the CNS, although only activation of NMDA receptors is involved in Ibo neurotoxicity. Ibotenic acid is toxic to cortical neurons exposes for 5 min with an EC50=77.3±8 μM (n=5) as measured by release of lactate dehydrogenase to the culture media[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2552-55-8
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Appearance Solid
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Molecular Weight 158.11
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Formel C5H6N2O4
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Color Light yellow to yellow
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SMILES
O=C(O)C(N)C(ON1)=CC1=O
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Synonyms
(RS)-Ibotenic acid; DL-Ibotenic acid
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Structure Classification
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Initial Source
Amanita mushrooms
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (7)
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Journal Impact Factor
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Most Recent
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Fundam Res
Glutamatergic neurons of piriform cortex delay induction of inhalational general anesthesia. [Abstract]2023 Jan 3;4(4):829-840. PMID: 39156577 -
CNS Neurosci Ther
Myelin modulates the process of isoflurane anesthesia through the regulation of neural activity. [Abstract]2024 Aug;30(8):e14922. PMID: 39138640 -
CNS Neurosci Ther
GABAergic neurons of anterior thalamic reticular nucleus regulate states of consciousness in propofol- and isoflurane-mediated general anesthesia. [Abstract]2024 Jun;30(6):e14782. PMID: 38828651 -
CNS Neurosci Ther
Overexpression of EphB2 in the basolateral amygdala is crucial for inducing visceral pain sensitization in rats subjected to water avoidance stress. [Abstract]2024 Feb;30(2):e14611. PMID: 38353051 -
J Physiol
Volitional modulation of neuronal activity in the external globus pallidus by engagement of the cortical-basal ganglia circuit. [Abstract]2024 Aug;602(15):3755-3768. PMID: 38979883 -
Brain Res Bull
The BDNF-TrkB signaling pathway in the rostral anterior cingulate cortex is involved in the development of pain aversion in rats with bone cancer via NR2B and ERK-CREB signaling. [Abstract]2022 Jul;185:18-27. PMID: 35398541 -
Neurosci Lett
2024 Apr 1:828:137753. PMID: 38554843
Lösungsmittel & Löslichkeit
H2O : 5 mg/mL (31.62 mM; Need ultrasonic)
DMSO : 5 mg/mL (31.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 0.5 mg/mL (3.16 mM); Clear solution
This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 0.5 mg/mL (3.16 mM); Clear solution
This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 8.67 mg/mL (54.84 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (479 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O / DMSO | 1 mM | 6.3247 mL | 31.6236 mL | 63.2471 mL | 158.1178 mL |
| 5 mM | 1.2649 mL | 6.3247 mL | 12.6494 mL | 31.6236 mL | |
| 10 mM | 0.6325 mL | 3.1624 mL | 6.3247 mL | 15.8118 mL | |
| 15 mM | 0.4216 mL | 2.1082 mL | 4.2165 mL | 10.5412 mL | |
| 20 mM | 0.3162 mL | 1.5812 mL | 3.1624 mL | 7.9059 mL | |
| 25 mM | 0.2530 mL | 1.2649 mL | 2.5299 mL | 6.3247 mL | |
| 30 mM | 0.2108 mL | 1.0541 mL | 2.1082 mL | 5.2706 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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