Art. -Nr.: HY-126358

Acetylcarnitine

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Acetylcarnitine is a CNS-penetrant endogenous metabolite. Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis. Acetylcarnitine attenuates oxidative stress and neuroinflammation. Acetylcarnitine can be used for fatigue-associated diseases research. Acetylcarnitine can be used as a candidate diagnostic and prognostic biomarker of hepatocellular carcinoma.

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Reinheit: 98.0%
CAS. Nr.: 14992-62-2
Formel: C₉H₁₇NO₄
Molecular Weight:203.24

Speicherung:

4°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Acetylcarnitine Chemical Structure

CAS. Nr.: 14992-62-2

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Biologische Aktivität
- Beschreibung
- In Vitro
- Clinical Trial
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

In Vitro

Acetylcarnitine (10 mM, 48 h) suppresses glucose-dependent labeling, particularly in ATP-citrate lyase (ACLY) KO cells^[2].
Acetylcarnitine (10 mM, 24-96 h) rescues histone acetylation and cell proliferation in ACLY/ACSS2 double knockout (DKO) cells under lipid-depleted conditions^[2].
Acetylcarnitine (10 mM, 24 h) boosts histone acetylation in ACLY KO cells in a carnitine acetyltransferase (CrAT)-independent manner, and increases total de novo lipogenesis (DNL) in ACLY KO CrAT KO cells, suggesting that acetylcarnitine can generate lipogenic acetyl-CoA without CrAT^[2].
Acetylcarnitine (10 mM, 24-96 h) promotes p300/CBP-dependent protein acetylation, as its pro-proliferative effect in DKO cells is blocked by the p300/CBP inhibitor A-485 (HY-107455)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[2]

Cell Line:

ACLY/ACSS2 DKO cells
Concentration:

10 mM
Incubation Time:

96 h
Result:

Rescued cell proliferation in DKO cells under lipid-depleted conditions.
The pro-proliferative effect of acetylcarnitine under lipid-depleted conditions was blocked by co-treatment with the p300/CBP inhibitor A-485.

Western Blot Analysis^[2]

Cell Line:

ACLY/ACSS2 DKO cells, ACLY KO cells, ACLY KO CrAT KO cells
Concentration:

10 mM
Incubation Time:

24 h
Result:

Rescued histone acetylation in ACLY/ACSS2 double knockout (DKO) cells under lipid-depleted conditions.
Promoted p300/CBP-dependent histone acetylation, specifically at H3K27.
Enhanced histone acetylation in ACLY KO cells in a CrAT-independent manner.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 14992-62-2
Appearance Solid
Molecular Weight 203.24
Formel C₉H₁₇NO₄
Color White to off-white
SMILES

C[N+](C)(C)CC(OC(C)=O)CC([O-])=O
Structure Classification
- Others
Initial Source
- Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 250 mg/mL (1230.07 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.9203 mL

24.6015 mL

49.2029 mL

5 mM

0.9841 mL

4.9203 mL

9.8406 mL

10 mM

0.4920 mL

2.4601 mL

4.9203 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Helbing DL, et al. Conceptual foundations of acetylcarnitine supplementation in neuropsychiatric long COVID syndrome: a narrative review. Eur Arch Psychiatry Clin Neurosci. 2024 Dec;274(8):1829-1845. [Content Brief]

[2]. Izzo LT, et al. Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis. Sci Adv. 2023 May 3;9(18):eadf0115. [Content Brief]

[3]. Lu Y, et al. Acetylcarnitine Is a Candidate Diagnostic and Prognostic Biomarker of Hepatocellular Carcinoma. Cancer Res. 2016 May 15;76(10):2912-20. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	4.9203 mL	24.6015 mL	49.2029 mL	123.0073 mL
	5 mM	0.9841 mL	4.9203 mL	9.8406 mL	24.6015 mL
	10 mM	0.4920 mL	2.4601 mL	4.9203 mL	12.3007 mL
	15 mM	0.3280 mL	1.6401 mL	3.2802 mL	8.2005 mL
	20 mM	0.2460 mL	1.2301 mL	2.4601 mL	6.1504 mL
	25 mM	0.1968 mL	0.9841 mL	1.9681 mL	4.9203 mL
	30 mM	0.1640 mL	0.8200 mL	1.6401 mL	4.1002 mL
	40 mM	0.1230 mL	0.6150 mL	1.2301 mL	3.0752 mL
	50 mM	0.0984 mL	0.4920 mL	0.9841 mL	2.4601 mL
	60 mM	0.0820 mL	0.4100 mL	0.8200 mL	2.0501 mL
	80 mM	0.0615 mL	0.3075 mL	0.6150 mL	1.5376 mL
	100 mM	0.0492 mL	0.2460 mL	0.4920 mL	1.2301 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Acetylcarnitine

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Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Acetylcarnitine Related Classifications

HY-126358 Related Classifications