AF615
Based on 1 Customer Validation
AF615 is a small molecule inhibitor targeting the CDT1/Geminin protein complex (IC50 = 0.313 μM). AF615 selectively induces DNA damage, inhibits DNA synthesis, causes cell cycle arrest, and decreases the survival rate in cancer cell lines. AF615 displayed a Ki = 0.37 μM in case of Geminin-tCDT1 interaction and a Ki = 0.75 μM in case of Geminin-miniCDT1 interaction.
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- Reinheit: 99.55%
- CAS. Nr.: 122510-61-6
- Formel: C10H13N5O2S
- Molecular Weight:267.31
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Chemical Information
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CAS. Nr. 122510-61-6
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Appearance Solid
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Molecular Weight 267.31
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Formel C10H13N5O2S
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Color Light yellow to light brown
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SMILES
O=C(C1=NC=CN=C1)NNC(N2CCOCC2)=S
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 25 mg/mL (93.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7410 mL | 18.7049 mL | 37.4097 mL | 93.5244 mL |
| 5 mM | 0.7482 mL | 3.7410 mL | 7.4819 mL | 18.7049 mL | |
| 10 mM | 0.3741 mL | 1.8705 mL | 3.7410 mL | 9.3524 mL | |
| 15 mM | 0.2494 mL | 1.2470 mL | 2.4940 mL | 6.2350 mL | |
| 20 mM | 0.1870 mL | 0.9352 mL | 1.8705 mL | 4.6762 mL | |
| 25 mM | 0.1496 mL | 0.7482 mL | 1.4964 mL | 3.7410 mL | |
| 30 mM | 0.1247 mL | 0.6235 mL | 1.2470 mL | 3.1175 mL | |
| 40 mM | 0.0935 mL | 0.4676 mL | 0.9352 mL | 2.3381 mL | |
| 50 mM | 0.0748 mL | 0.3741 mL | 0.7482 mL | 1.8705 mL | |
| 60 mM | 0.0623 mL | 0.3117 mL | 0.6235 mL | 1.5587 mL | |
| 80 mM | 0.0468 mL | 0.2338 mL | 0.4676 mL | 1.1691 mL |
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