Art. -Nr.: HY-N2460

Aloesin

(Synonyms: Aloeresin)

1 Cited Publications

Kundenbewertung

Based on 1 publication(s) in Google Scholar

Aloesin (Aloeresin) is a tyrosinase inhibitor, and shows anti-inflammatory activity, ultraviolet protection, and antibacterium effects. Aloesin can induce apoptosis and be used in ovarian cancer research.

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Reinheit: 99.62%
CAS. Nr.: 30861-27-9
Formel: C₁₉H₂₂O₉
Molecular Weight:394.37

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Aloesin Chemical Structure

CAS. Nr.: 30861-27-9

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Aloesin (0-40 μM, 24, 48, and 72 h) inhibits ovarian cancer cell growth in a dose- and time-dependent manner^[1].
Aloesin (0-10 μM; 48 h) arrest the cell cycle at S-phase in a dose-dependent manner in SKOV3 cells^[1].
Aloesin (0-10 μM; 48 h) promotes cell apoptosis in SKOV3 cells^[1].
Aloesin (0-10 μM; 48 h) inhibits the phosphorylation of the MAPK signaling pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

MCF10A, T47D, MCF7, MDA-MB-468, and MDA-MB-231 cells
Concentration:

0, 2.5, 5, 10, 20, and 40 μM
Incubation Time:

24, 48, and 72 h
Result:

Exhibited a concentration-dependent and time-dependent killing of diverse ovarian cancer cell lines.

Cell Viability Assay^[1]

Cell Line:

SKOV3 cells
Concentration:

2.5-10 μM
Incubation Time:

48 hours
Result:

Showed a significantly potent toxic effect with an IC₅₀ value of around 5 μM.

Cell Cycle Analysis^[1]

Cell Line:

SKOV3 cells
Concentration:

0, 2.5, 5, and 10 μM
Incubation Time:

48 h
Result:

Decresed the percentage of cells in the G2/M phase gradually with increasing doses, increased the percentages of cells in the S-phase.
Downregulated the levels of the S-G2/M-related proteins cyclin A, CDK2, and cyclin D1.

Apoptosis Analysis^[1]

Cell Line:

SKOV3 cells
Concentration:

0, 2.5, 5, and 10 μM
Incubation Time:

48 h
Result:

Detected significant proteolytic cleavage of caspase-3, caspase-9, and PARP1.
Increased the expression of Bax and conversely decreased Bcl-2.

Western Blot Analysis^[1]

Cell Line:

SKOV3 cells
Concentration:

0, 2.5, 5, and 10 μM
Incubation Time:

48 h
Result:

Decreased phosphorylated levels of MEK, ERK, MAPK, and JNK.

In Vivo

Aloesin (injection; 20 mg/kg or 40 mg/kg; once daily; 7 w) inhibits tumor growth in a Xenograft model of ovarian cancer^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

6-week-old athymic nude mice injected with SKOV3 cells
Dosage:

20 mg/kg or 40 mg/kg
Administration:

Injection; 20 mg/kg or 40 mg/kg; once daily; 7 weeks
Result:

Reduced volumes and average weights of dissected tumors significantly compared with the control group.

Chemical Information

CAS. Nr. 30861-27-9
Appearance Solid
Molecular Weight 394.37
Formel C₁₉H₂₂O₉
Color White to off-white
SMILES

OC1=CC(C)=C(C(C=C(CC(C)=O)O2)=O)C2=C1[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO
Synonyms

Aloeresin
Structure Classification
- Phenols
- Monophenols
- Ketones, Aldehydes, Acids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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Journal Impact Factor

University of Paris

2022 Sep 19.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (253.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5357 mL

12.6784 mL

25.3569 mL

5 mM

0.5071 mL

2.5357 mL

5.0714 mL

10 mM

0.2536 mL

1.2678 mL

2.5357 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.25 mg/mL (5.71 mM); Clear solution

This protocol yields a clear solution of ≥ 2.25 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (22.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.25 mg/mL (5.71 mM); Clear solution

This protocol yields a clear solution of ≥ 2.25 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (22.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.25 mg/mL (5.71 mM); Clear solution

This protocol yields a clear solution of ≥ 2.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (22.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (284 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhang LQ, et al. Aloesin Suppresses Cell Growth and Metastasis in Ovarian Cancer SKOV3 Cells through the Inhibition of the MAPK Signaling Pathway. Anal Cell Pathol (Amst). 2017;2017:8158254. [Content Brief]

[2]. Wahedi HM, et al. Aloesin from Aloe vera accelerates skin wound healing by modulating MAPK/Rho and Smad signaling pathways in vitro and in vivo. Phytomedicine. 2017 May 15;28:19-26. [Content Brief]

[3]. Y H Jin, et al. Aloesin and arbutin inhibit tyrosinase activity in a synergistic manner via a different action mechanism. Arch Pharm Res. 1999 Jun;22(3):232-6. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.5357 mL	12.6784 mL	25.3569 mL	63.3922 mL
	5 mM	0.5071 mL	2.5357 mL	5.0714 mL	12.6784 mL
	10 mM	0.2536 mL	1.2678 mL	2.5357 mL	6.3392 mL
	15 mM	0.1690 mL	0.8452 mL	1.6905 mL	4.2261 mL
	20 mM	0.1268 mL	0.6339 mL	1.2678 mL	3.1696 mL
	25 mM	0.1014 mL	0.5071 mL	1.0143 mL	2.5357 mL
	30 mM	0.0845 mL	0.4226 mL	0.8452 mL	2.1131 mL
	40 mM	0.0634 mL	0.3170 mL	0.6339 mL	1.5848 mL
	50 mM	0.0507 mL	0.2536 mL	0.5071 mL	1.2678 mL
	60 mM	0.0423 mL	0.2113 mL	0.4226 mL	1.0565 mL
	80 mM	0.0317 mL	0.1585 mL	0.3170 mL	0.7924 mL
	100 mM	0.0254 mL	0.1268 mL	0.2536 mL	0.6339 mL

Keywords

Aloesin

1 Cited Publications

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Publications Citing Use of MedChemExpress (MCE) Aloesin

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Aloesin Related Classifications

HY-N2460 Related Classifications