AMG8380
AMG8380, an orally active and less active enantiomer of AMG8379, can serves as a negative control. AMG8380 inhibits human and mouse voltage-gated sodium channel NaV1.7 with IC50s of 0.907 and 0.387 μM, respectively. AMG8380 blocks Tetrodotoxin (TTX)-sensitive native channels with an IC50 of 2560 nM.
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- CAS. Nr.: 1642112-32-0
- Formel: C25H16ClF2N3O5S
- Molecular Weight:543.93
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
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hNav1.7 0.907 μM (IC50) |
mNav1.7 0.387 μM (IC50) |
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Animal Model:C57Bl/6 male mice[1]
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Dosage:100 mg/kg
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Administration:oral
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Result:Failed to show a statistically significant effect on scratching behavior.
Chemical Information
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CAS. Nr. 1642112-32-0
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Molecular Weight 543.93
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Formel C25H16ClF2N3O5S
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SMILES
O=S(NC1=NOC=C1)(C2=CC(C=CC(N3C4=CC(F)=C(C=C4OC)C5=CC(Cl)=CC(F)=C5)=O)=C3C=C2)=O.[R]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
AMG8380 Related Classifications
HY-108425A Related Classifications
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