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Art. -Nr.: HY-158025

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Anticancer agent 198

Anticancer agent 198 (compound 18b) is a potent anticancer agent and potential WRN protein inhibitor. Anticancer agent 198 was significantly toxic to K562 cells and WRN-overexpressing PC3 cells.

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Formel: C₂₅H₂₃F₂N₃O₃
Molecular Weight:451.47

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Anticancer agent 198 Chemical Structure

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
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Bioz

Biologische Aktivität

Beschreibung

Anticancer agent 198 (compound 18b) is a potent anticancer agent and potential WRN protein inhibitor. Anticancer agent 198 was significantly toxic to K562 cells and WRN-overexpressing PC3 cells^[1].

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Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>10 μM Compound: 18b	Antiproliferative activity against human A549 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 48 hrs by MTT assay	[PMID: 38442524]
HEK-293T	IC₅₀	1.1 μM Compound: 18b	Antiproliferative activity against HEK293T cells incubated for 48 hrs by MTT assay Antiproliferative activity against HEK293T cells incubated for 48 hrs by MTT assay	[PMID: 38442524]
HeLa	IC₅₀	>10 μM Compound: 18b	Antiproliferative activity against human HeLa cells incubated for 48 hrs by MTT assay Antiproliferative activity against human HeLa cells incubated for 48 hrs by MTT assay	[PMID: 38442524]
K562	IC₅₀	0.05 μM Compound: 18b	Antiproliferative activity against human K562 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human K562 cells incubated for 48 hrs by MTT assay	[PMID: 38442524]
PC-3	IC₅₀	>10 μM Compound: 18b	Antiproliferative activity against human PC-3 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human PC-3 cells incubated for 48 hrs by MTT assay	[PMID: 38442524]

In Vitro

Anticancer agent 198 significantly inhibits the survival of PC3-WRN cells, with IC20 of 0.12 μM and 0.98 μM between PC3-WRN (OE) cells and PC3 cells, respectively^[1].
Anticancer agent 198 (5 μM) against several cancers The IC₅₀s of the cell lines are >10 μM (PC3 cells), 0.05 μM (K562 cells), and 1.1 μM (293T cells)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

PC3, K562, A549, HeLa, 293T cells
Concentration:

5 μM
Incubation Time:
Result:

Showed inhibition rates of 62.7% (PC3), 65.57% (K562), 53.27% (HeLa), 51.27% (A549), 63.67% (293T), respectively.

Chemical Information

Molecular Weight 451.47
Formel C₂₅H₂₃F₂N₃O₃
SMILES

COC1=CC=CC(C(F)(C2=NC3=CC=CC=C3C(N(C4=CC(OC)=C(C=C4)OC)C)=N2)F)=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wang M, et al. Design, synthesis and antitumor activity of 2-substituted quinazoline-4-amine derivatives. Bioorg Med Chem. 2024 Mar 15;102:117660. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
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- In Vitro
Chemical Information
Reinheit & Dokumentation
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Anticancer agent 198

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Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Anticancer agent 198 Related Classifications

HY-158025 Related Classifications