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Art. -Nr.: HY-169867

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BNTX

(Synonyms: 7-Benzylidenenaltrexone)

BNTX (7-Benzylidenenaltrexone) is a highly selective δ1 opioid receptor antagonist. BNTX selectively antagonizes the antinociceptive activity mediated by spinal δ₁ opioid receptors, and does not alter the antinociceptive effects mediated by δ₂, μ or κ opioid receptors at selective doses.

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CAS. Nr.: 129468-28-6
Formel: C₂₇H₂₇NO₄
Molecular Weight:429.51

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (280 KB)

BNTX Chemical Structure

CAS. Nr.: 129468-28-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
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Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

δ Opioid Receptor/DOR

Alle Opioid Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

BNTX is highly selective for δ₁ opioid receptors in guinea pig brain membranes, with 100-fold greater affinity for δ₁ versus δ₂ sites^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BNTX (1.3 μmol/kg; subcutaneous injection; single administration; 1 pmole per mouse; intrathecal injection; single administration) acts as a highly selective δ₁ opioid receptor antagonist in the mouse spinal cord, and significantly increases the antinociceptive ED₅₀ of the δ₁ receptor agonist DPDPE (HY-P1334)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ND4 Swiss-Webster (male, 20-25 g)^[1]
Dosage:

1.3 μmol/kg (s.c. pretreatment); 1 pmole/mouse (i.t. pretreatment)
Administration:

s.c.; single dose, 30 minutes prior to agonist assay; i.t.; single dose, 10 minutes prior to agonist assay
Result:

Increased the antinociceptive ED₅₀ of δ₁ agonist DPDPE (i.t.) from 6.3 to 36.1 nmol/mouse at 1.3 μmol/kg s.c. dose.
Did not significantly alter the antinociceptive ED₅₀ of δ₂ agonist DELT II (i.t.), μ agonists DAMGO and morphine (i.t.), or κ agonist U-50,488H (i.t.), at 1.3 μmol/kg s.c. dose.
Increased the antinociceptive ED₅₀ of DPDPE (i.t.) from 6.3 to 25.5 nmol/mouse at 1 pmole/mouse i.t. dose.
Did not significantly alter the antinociceptive ED₅₀ of DELT II (i.t.), μ agonist DAMGO (i.t.), or κ agonist U-50,488H (i.t.), at 1 pmole/mouse i.t. dose.

Chemical Information

CAS. Nr. 129468-28-6
Molecular Weight 429.51
Formel C₂₇H₂₇NO₄
SMILES

O[C@]12[C@@]34C5=C(C[C@@]2([H])N(CC4)CC6CC6)C=CC(O)=C5O[C@@]3([H])C(/C(C1)=C\C7=CC=CC=C7)=O
Synonyms

7-Benzylidenenaltrexone
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Sofuoglu M, et al. 7-Benzylidenenaltrexone (BNTX): a selective delta 1 opioid receptor antagonist in the mouse spinal cord. Life Sci. 1993;52(8):769-775. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
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BNTX

Alle Opioid Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

BNTX Related Classifications

HY-169867 Related Classifications