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Art. -Nr.: HY-114804

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BRD2577

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BRD2577 is a selective mercaptopyruvate sulfurtransferase (3-MST) inhibitor with an IC₅₀ of 9.9 μM. BRD2577 inhibits H₂S production in colon carcinoma cells. BRD2577 exhibits weak to no significant inhibitory effect on colon cancer cell proliferation and mitochondrial activity. BRD2577 can be used for the research of colon cancer.

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CAS. Nr.: 353781-42-7
Formel: C₁₅H₁₅N₃O₃S
Molecular Weight:317.36

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

BRD2577 Chemical Structure

CAS. Nr.: 353781-42-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

MST3

9.9 μM (IC₅₀)

Alle Hippo (MST) Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
CT26	IC₅₀	>1 mM Compound: 13a	Antiproliferative activity against mouse CT26 cells assessed as inhibition of cell proliferation measured after 24 hrs by MTT assay Antiproliferative activity against mouse CT26 cells assessed as inhibition of cell proliferation measured after 24 hrs by MTT assay	[PMID: 33856792]
CT26	IC₅₀	1000 μM Compound: 13a	Antiproliferative activity against mouse CT26 cells assessed as inhibition of cell proliferation measured after 24 hrs by MTT assay Antiproliferative activity against mouse CT26 cells assessed as inhibition of cell proliferation measured after 24 hrs by MTT assay	[PMID: 33856792]
MC-38	IC₅₀	>1 mM Compound: 13a	Antiproliferative activity against mouse MC38 cells assessed as inhibition of cell proliferation measured after 24 hrs by MTT assay Antiproliferative activity against mouse MC38 cells assessed as inhibition of cell proliferation measured after 24 hrs by MTT assay	[PMID: 33856792]

In Vitro

BRD2577 (Compound 13a) (3-300 μM; 1 h) potently inhibits recombinant human 3-MST with an IC₅₀ of 9.9 μM and achieves ≥60% inhibition at 100 μM, and shows no activity against human recombinant CBS or CSE at concentrations up to 300 μM^[1].
BRD2577 (300 μM; 2 h) does not act as an H₂S scavenger at 300 μM, confirming its inhibitory effect is direct against 3-MST^[1].
BRD2577 (300 μM; 4 h) inhibits H₂S production in live murine CT26 and MC38 colon carcinoma cells^[1].
BRD2577 (3-300 μM; 48 h) does not significantly inhibit the proliferation of murine CT26 or MC38 colon carcinoma cells at concentrations up to 300 μM after 48 h of treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

Murine CT26 colon carcinoma cells, murine MC38 colon carcinoma cells
Concentration:

3, 10, 30, 100, 300 μM
Incubation Time:

48 h
Result:

Did not significantly inhibit CT26 or MC38 cell proliferation at tested concentrations.
Showed an IC₅₀ values were >1000 μM for both cell lines.

Chemical Information

CAS. Nr. 353781-42-7
Molecular Weight 317.36
Formel C₁₅H₁₅N₃O₃S
SMILES

O=C1N=C(SCC(=O)C2=CC=C(C=C2)NC(=O)C)NC(=C1)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Bantzi M, et al. Novel Aryl-Substituted Pyrimidones as Inhibitors of 3-Mercaptopyruvate Sulfurtransferase with Antiproliferative Efficacy in Colon Cancer. J Med Chem. 2021;64(9):6221-6240. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
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BRD2577

High-Throughput Bioactive Compound Library

Alle Hippo (MST) Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

BRD2577 Related Classifications

HY-114804 Related Classifications