Art. -Nr.: HY-109081

Cedazuridine

(Synonyms: E7727)

1 Cited Publications

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Cedazuridine (E7727) (Compound 7a) is an orally active cytidine deaminase (CDA) inhibitor with an IC₅₀ value of 0.4 μM. Cedazuridine can be used for cancer research.

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Reinheit: 99.72%
CAS. Nr.: 1141397-80-9
Formel: C₉H₁₄F₂N₂O₅
Molecular Weight:268.21

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Cedazuridine Chemical Structure

CAS. Nr.: 1141397-80-9

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cedazuridine (E7727) (Compound 7a) is an orally active cytidine deaminase (CDA) inhibitor with an IC₅₀ value of 0.4 μM. Cedazuridine can be used for cancer research^[1].

IC₅₀ & Target

IC50: 0.4 μM (CDA)^[1]

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

In Vitro

Cedazuridine (Compound 7a) exhibits superior acid stability^[1].
Cedazuridine (0-10 μM; 72 h) does not enhance effects of AZA (5-Azacytidine, HY-10586) in growth inhibition of AML cell lines^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cedazuridine (3 mg/kg; p.o.; daily for 7 days) in combination with 2.5 mg/kg AZA shows tumor regression in mice MOLM-13 CDX and PDX models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female NSGS mice, 6–8 weeks old, human cell line-derived (CDX) and primary patient-derived xenograft (PDX) models^[2]
Dosage:

3 mg/kg
Administration:

Oral administration, in combination with 2.5 mg/kg AZA, daily for 7 days
Result:

Led to reduction of leukemic expansion in combination with AZA in a cell line-derived xenograft transplantation, and exhibited preliminary safety and efcacy in a primary AML PDX model.

Animal Model:

NSGS male mice^[2]
Dosage:

1, 3, 10 and 30 mg/kg
Administration:

Oral, in combination with 2.5 mg/kg AZA (Pharmacokinetic Studies)
Result:

Dose-dependently increased the AUC of oral AZA and in comparison to dosing of standard i.p. AZA.

Chemical Information

CAS. Nr. 1141397-80-9
Appearance Solid
Molecular Weight 268.21
Formel C₉H₁₄F₂N₂O₅
Color White to off-white
SMILES

O[C@H]1C(F)(F)[C@H](N(CC[C@@H](O)N2)C2=O)O[C@@H]1CO
Synonyms

E7727
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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Journal Impact Factor

Cancer Res Commun

Mechanisms Underlying Cedazuridine-Mediated Enhancement of Oral Decitabine Bioavailability. [Abstract]

2026 Mar 2. PMID: 41770597

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 116.67 mg/mL (434.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.7284 mL

18.6421 mL

37.2842 mL

5 mM

0.7457 mL

3.7284 mL

7.4568 mL

10 mM

0.3728 mL

1.8642 mL

3.7284 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Ferraris D, et al. Design, synthesis, and pharmacological evaluation of fluorinated tetrahydrouridine derivatives as inhibitors of cytidine deaminase. J Med Chem. 2014 Mar 27; 57(6):2582-8. [Content Brief]

[2]. Ramsey H E, et al. Oral azacitidine and cedazuridine approximate parenteral azacitidine efficacy in murine model. Targeted Oncology, 2020, 15(2): 231-240.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.7284 mL	18.6421 mL	37.2842 mL	93.2105 mL
	5 mM	0.7457 mL	3.7284 mL	7.4568 mL	18.6421 mL
	10 mM	0.3728 mL	1.8642 mL	3.7284 mL	9.3211 mL
	15 mM	0.2486 mL	1.2428 mL	2.4856 mL	6.2140 mL
	20 mM	0.1864 mL	0.9321 mL	1.8642 mL	4.6605 mL
	25 mM	0.1491 mL	0.7457 mL	1.4914 mL	3.7284 mL
	30 mM	0.1243 mL	0.6214 mL	1.2428 mL	3.1070 mL
	40 mM	0.0932 mL	0.4661 mL	0.9321 mL	2.3303 mL
	50 mM	0.0746 mL	0.3728 mL	0.7457 mL	1.8642 mL
	60 mM	0.0621 mL	0.3107 mL	0.6214 mL	1.5535 mL
	80 mM	0.0466 mL	0.2330 mL	0.4661 mL	1.1651 mL
	100 mM	0.0373 mL	0.1864 mL	0.3728 mL	0.9321 mL

Keywords

Cedazuridine

1 Cited Publications

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Cedazuridine

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Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Cedazuridine

Cell Cycle/DNA Damage Compound Library

FDA-Approved Drug Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Drug Repurposing Compound Library

Orally Active Compound Library

FDA Approved & Pharmacopeial Drug Library

FDA-Approved Anticancer Drug Library

Human Metabolite Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

FDA-Approved Drug Library Mini

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Anti-Cancer Approved Drug Library

Mass Spectrometry Human Metabolite Library

Publications Citing Use of MedChemExpress (MCE) Cedazuridine

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Cedazuridine Related Classifications

HY-109081 Related Classifications