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Art. -Nr.: HY-121862

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CM03

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CM03 is a potent DNA G-quadruplexes (G4s) ligand. CM03 can stabilise G4s, downregulating more G4-containing genes as well as increasing incidence of double-strand break events (DSBs) due to torsional strain on DNA and chromatin structure. CM03 has selective potency for pancreatic cancer cells.

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Reinheit: 98.23%
CAS. Nr.: 2101208-44-8
Formel: C₃₄H₄₄N₆O₆
Molecular Weight:632.75

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

CM03 Chemical Structure

CAS. Nr.: 2101208-44-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

DNA synthesis^[1]

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	24 nM Compound: CM03	Growth inhibition of human A549 cells after 96 hrs by SRB assay Growth inhibition of human A549 cells after 96 hrs by SRB assay	[PMID: 29356532]
BXPC-3	GI₅₀	15.5 nM Compound: CM03	Antiproliferative activity against human BxPC3 cells assessed as growth inhibition after 96 hrs by SRB assay Antiproliferative activity against human BxPC3 cells assessed as growth inhibition after 96 hrs by SRB assay	[PMID: 32832034]
BXPC-3	IC₅₀	19 nM Compound: CM03	Growth inhibition of human BxPC3 cells after 96 hrs by SRB assay Growth inhibition of human BxPC3 cells after 96 hrs by SRB assay	[PMID: 29356532]
CAPAN-1	GI₅₀	26.5 nM Compound: CM03	Antiproliferative activity against human Capan1 cells assessed as growth inhibition after 96 hrs by SRB assay Antiproliferative activity against human Capan1 cells assessed as growth inhibition after 96 hrs by SRB assay	[PMID: 32832034]
CAPAN-1	IC₅₀	16 nM Compound: CM03	Growth inhibition of human Capan1 cells after 96 hrs by SRB assay Growth inhibition of human Capan1 cells after 96 hrs by SRB assay	[PMID: 29356532]
MCF7	IC₅₀	159 nM Compound: CM03	Growth inhibition of human MCF7 cells after 96 hrs by SRB assay Growth inhibition of human MCF7 cells after 96 hrs by SRB assay	[PMID: 29356532]
MIA PaCa-2	GI₅₀	400 nM Compound: CM03	Growth inhibition of human MIAPaCa2 cells after 24 hrs by CellTiter-Glo luminescent cell viability assay Growth inhibition of human MIAPaCa2 cells after 24 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 29356532]
MIA PaCa-2	GI₅₀	9 nM Compound: CM03	Antiproliferative activity against human MIAPaCa2 cells assessed as growth inhibition after 96 hrs by SRB assay Antiproliferative activity against human MIAPaCa2 cells assessed as growth inhibition after 96 hrs by SRB assay	[PMID: 32832034]
MIA PaCa-2	IC₅₀	7 nM Compound: CM03	Growth inhibition of human MIAPaCa2 cells after 96 hrs by SRB assay Growth inhibition of human MIAPaCa2 cells after 96 hrs by SRB assay	[PMID: 29356532]
PANC-1	GI₅₀	15.6 nM Compound: CM03	Antiproliferative activity against human PANC1 cells assessed as growth inhibition after 96 hrs by SRB assay Antiproliferative activity against human PANC1 cells assessed as growth inhibition after 96 hrs by SRB assay	[PMID: 32832034]
PANC-1	GI₅₀	400 nM Compound: CM03	Growth inhibition of human PANC1 cells after 24 hrs by CellTiter-Glo luminescent cell viability assay Growth inhibition of human PANC1 cells after 24 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 29356532]
PANC-1	IC₅₀	18 nM Compound: CM03	Growth inhibition of human PANC1 cells after 96 hrs by SRB assay Growth inhibition of human PANC1 cells after 96 hrs by SRB assay	[PMID: 29356532]
WI-38	IC₅₀	1190 nM Compound: CM03	Growth inhibition of human WI38 cells after 96 hrs by SRB assay Growth inhibition of human WI38 cells after 96 hrs by SRB assay	[PMID: 29356532]

In Vitro

CM03 (0.4 μM; 24 or 48 h) increases the level of γ-H2AX protein when in combination with SAHA (HY-10221) in MIA PaCa-2 and PANC-1^[1].
CM03 (0-100 nM; 96 h) exhibits highly anti-proliferative activity against pancreatic cancer cell lines^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

MIA PaCa-2 and PANC-1
Concentration:

0.4 μM
Incubation Time:

24 h for MIA PaCa-2, 48 h for PANC-1
Result:

Significantly increased the level of γ-H2AX protein when in combination with SAHA (HY-10221) (1 μM).

Cell Proliferation Assay^[2]

Cell Line:

MIA PaCa-2, PANC-1, Capan-1 and BxPC-3
Concentration:

0-100 nM
Incubation Time:

96 h
Result:

Exhibited highly anti-proliferative activity against pancreatic cancer cell lines with GI₅₀s of 9.0 nM, 15.6 nM, 26.5 nM and 15.5 nM in MIA PaCa-2, PANC-1, Capan-1 and BxPC-3, respectively.

Chemical Information

CAS. Nr. 2101208-44-8
Appearance Solid
Molecular Weight 632.75
Formel C₃₄H₄₄N₆O₆
Color Brown to dark brown
SMILES

O=C(C1=CC=C2C3=O)N(C(C4=C1C2=C(C=C4NCCN5CCCC5)C(N3CCCN6CCOCC6)=O)=O)CCCN7CCOCC7
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 2 mg/mL (3.16 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.5804 mL

7.9020 mL

15.8040 mL

5 mM

---

10 mM

---

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Ahmed AA, et al. A G-Quadruplex-Binding Small Molecule and the HDAC Inhibitor SAHA (Vorinostat) Act Synergistically in Gemcitabine-Sensitive and Resistant Pancreatic Cancer Cells. Molecules. 2020 Nov 19;25(22):5407. [Content Brief]

[2]. Ahmed AA, et al. Asymmetrically Substituted Quadruplex-Binding Naphthalene Diimide Showing Potent Activity in Pancreatic Cancer Models. ACS Med Chem Lett. 2020 Jul 16;11(8):1634-1644. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.5804 mL	7.9020 mL	15.8040 mL	39.5101 mL

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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