Art. -Nr.: HY-N4283

Coniferyl alcohol

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Coniferyl alcohol is an orally active lignin biosynthesis intermediate and antifungal agent. Coniferyl alcohol specifically inhibits the growth of fungi (Verticillium longisporum). Coniferyl alcohol inhibits the growth of Nicotiana benthamiana seedlings. Coniferyl alcohol improves cardiac dysfunction in renovascular hypertension and cardiac inflammation.

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Reinheit: 99.94%
CAS. Nr.: 458-35-5
Formel: C₁₀H₁₂O₃
Molecular Weight:180.20

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Coniferyl alcohol Chemical Structure

CAS. Nr.: 458-35-5

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Fungal^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	85 μM Compound: 39	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 21696954]
B16-4A5	IC₅₀	16.1 μM Compound: 14	Antimelanogenic activity in theophylline-stimulated mouse B16-4A5 cells assessed as inhibition of melanogenesis after 72 hrs relative to control Antimelanogenic activity in theophylline-stimulated mouse B16-4A5 cells assessed as inhibition of melanogenesis after 72 hrs relative to control	[PMID: 27756508]
Col2	IC₅₀	>20 μg/mL Compound: 10	Cytotoxicity against human Col2 cells Cytotoxicity against human Col2 cells	[PMID: 14987058]
HUVEC	IC₅₀	>20 μg/mL Compound: 10	Cytotoxicity against HUVEC Cytotoxicity against HUVEC	[PMID: 14987058]
KB	IC₅₀	>20 μg/mL Compound: 10	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 14987058]
LNCaP	IC₅₀	>20 μg/mL Compound: 10	Cytotoxicity against human LNCAP cells Cytotoxicity against human LNCAP cells	[PMID: 14987058]
LoVo	IC₅₀	64 μM Compound: 39	Cytotoxicity against human LoVo cells after 72 hrs by MTT assay Cytotoxicity against human LoVo cells after 72 hrs by MTT assay	[PMID: 21696954]
Lu1	IC₅₀	>20 μg/mL Compound: 10	Cytotoxicity against human Lu1 cells Cytotoxicity against human Lu1 cells	[PMID: 14987058]
PC-3	IC₅₀	84 μM Compound: 39	Cytotoxicity against human PC3 cells after 72 hrs by MTT assay Cytotoxicity against human PC3 cells after 72 hrs by MTT assay	[PMID: 21696954]
SK-MEL-28	IC₅₀	>100 μM Compound: 39	Cytotoxicity against human SK-MEL-28 cells after 72 hrs by MTT assay Cytotoxicity against human SK-MEL-28 cells after 72 hrs by MTT assay	[PMID: 21696954]
U-373MG ATCC	IC₅₀	97 μM Compound: 39	Cytotoxicity against human U373 cells after 72 hrs by MTT assay Cytotoxicity against human U373 cells after 72 hrs by MTT assay	[PMID: 21696954]

In Vitro

Coniferyl alcohol (10-100 μM) inhibits the growth of Verticillium longisporum up to 20% (10 μM) and up to 30% (100 μM)^[2].
Coniferyl alcohol (0.5-2 mM) reduces the growth of tobacco BY-2 cells in a concentration-dependent manner, with the effect being a prolonged lag phase^[3].
Coniferyl alcohol (0.5-5 mM; 9 days) reduces the growth of Nicotiana benthamiana seedlings in a dose-dependent manner and causes the formation of a lignin-like compound in the roots^[3].
Coniferyl alcohol (50 μM; 24 h) significantly alleviates the decreased viability of H9C2 cells caused by Ang II (HY-13948)^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Coniferyl alcohol (20-40 mg/kg; i.g.; once daily; 3 weeks) reduces systolic and diastolic blood pressures, alleviates cardiac inflammation and hypertrophy in 2K1C mice with renovascular hypertension^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

6-8-week-old male C57BL/6 mice with two-kidney, one-clip (2K1C) renovascular hypertension model^[4]
Dosage:

20 mg/kg, 40 mg/kg
Administration:

Intragastric administration, once daily for 3 weeks
Result:

Reduced systolic and diastolic blood pressures.
Alleviated cardiac inflammation and hypertrophy, as shown by a reduction in the heart weight/body weight (HW/BW) ratio, improvement in echocardiographic indices (such as IVS, LVPW, EF, and FS), and alleviation of myocardial cell injury, inflammatory penetration, and necrosis in heart tissues.

Chemical Information

CAS. Nr. 458-35-5
Appearance Solid
Molecular Weight 180.20
Formel C₁₀H₁₂O₃
Color White to off-white
SMILES

OC1=CC=C(/C=C/CO)C=C1OC
Structure Classification
- Phenylpropanoids
- Simple Phenylpropanols
- Phenols
- Monophenols
Initial Source
- Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (554.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

5.5494 mL

27.7469 mL

55.4939 mL

5 mM

1.1099 mL

5.5494 mL

11.0988 mL

10 mM

0.5549 mL

2.7747 mL

5.5494 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (11.54 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (11.54 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (11.54 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Keeling CI, et al. New components of the honey bee (Apis mellifera L.) queen retinue pheromone. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4486-91. [Content Brief]

[2]. König S, et al. Soluble phenylpropanoids are involved in the defense response of Arabidopsis against Verticillium longisporum. New Phytol. 2014 May;202(3):823-37. [Content Brief]

[3]. Väisänen EE, et al. Coniferyl alcohol hinders the growth of tobacco BY-2 cells and Nicotiana benthamiana seedlings. Planta. 2015 Sep;242(3):747-60. [Content Brief]

[4]. Wu Q, et al. Mechanism Actions of Coniferyl Alcohol in Improving Cardiac Dysfunction in Renovascular Hypertension Studied by Experimental Verification and Network Pharmacology. Int J Mol Sci. 2024 Sep 19;25(18):10063. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	5.5494 mL	27.7469 mL	55.4939 mL	138.7347 mL
	5 mM	1.1099 mL	5.5494 mL	11.0988 mL	27.7469 mL
	10 mM	0.5549 mL	2.7747 mL	5.5494 mL	13.8735 mL
	15 mM	0.3700 mL	1.8498 mL	3.6996 mL	9.2490 mL
	20 mM	0.2775 mL	1.3873 mL	2.7747 mL	6.9367 mL
	25 mM	0.2220 mL	1.1099 mL	2.2198 mL	5.5494 mL
	30 mM	0.1850 mL	0.9249 mL	1.8498 mL	4.6245 mL
	40 mM	0.1387 mL	0.6937 mL	1.3873 mL	3.4684 mL
	50 mM	0.1110 mL	0.5549 mL	1.1099 mL	2.7747 mL
	60 mM	0.0925 mL	0.4624 mL	0.9249 mL	2.3122 mL
	80 mM	0.0694 mL	0.3468 mL	0.6937 mL	1.7342 mL
	100 mM	0.0555 mL	0.2775 mL	0.5549 mL	1.3873 mL

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Coniferyl alcohol

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Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Coniferyl alcohol

Anti-Infection Compound Library

Immunology/Inflammation Compound Library

Natural Product Library

Anti-Cardiovascular Disease Compound Library

Antifungal Compound Library

Medicine Food Homology Compound Library

Phenols Library

Orally Active Compound Library

Traditional Chinese Medicine Active Compound Library

FDA Approved & Pharmacopeial Drug Library

Food-Sourced Compound Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Human Metabolite Library

Highly Selective Inhibitors Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Miao Ethnicity Medicine Compound Library

Tibetan Medicine Compound Library

Heat-Clearing and Detoxification Traditional Chinese Medicine Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

Mass Spectrometry Human Metabolite Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Mongolian Medicine Compound Library

Tonifying Traditional Chinese Medicine Monomer Compound Library

Mass Spectrometry Natural Product Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Coniferyl alcohol Related Classifications

HY-N4283 Related Classifications