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Art. -Nr.: HY-N3665

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Cyclocommunol

Cyclocommunol is a GST inhibitor with an IC₅₀ of 3.0 μM. Cyclocommunol downregulates the expression of the anti-apoptotic (apoptosis) protein Mcl-1, reduces the levels of phosphorylated Akt and mTOR, and induces caspase-dependent apoptosis, reactive oxygen species (ROS) production and autophagy. Cyclocommunol can be used in research related to oral squamous cell carcinoma, breast cancer, lung cancer, norovirus-induced gastroenteritis and bacterial infections.

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CAS. Nr.: 145643-96-5
Formel: C₂₀H₁₆O₆
Molecular Weight:352.34

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (290 KB)

Cyclocommunol Chemical Structure

CAS. Nr.: 145643-96-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[2]

Mcl-1

Akt

mTOR

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Cellular Effect

Cell Line	Type	Value	Description	References
Ca9-22	IC50	5.6 μM	Suppression of cell viability against human oral squamous cell carcinoma Ca922 cells incubated for 24 hrs by MTT assay. Suppression of cell viability against human oral squamous cell carcinoma Ca922 cells incubated for 24 hrs by MTT assay.	29433680
Ca9-22	IC50	5.0 μM	Suppression of cell viability against human oral squamous cell carcinoma Ca922 cells incubated for 48 hrs by MTT assay. Suppression of cell viability against human oral squamous cell carcinoma Ca922 cells incubated for 48 hrs by MTT assay.	29433680
MCF7	IC50	> 100 μM	Cytotoxicity against human MCF-7 breast cancer cells, with no detectable cytotoxicity observed. Cytotoxicity against human MCF-7 breast cancer cells, with no detectable cytotoxicity observed.	40017003
NCI-H460	IC50	> 100 μM	Cytotoxicity against human NCI-H460 lung cancer cells, with no detectable cytotoxicity observed. Cytotoxicity against human NCI-H460 lung cancer cells, with no detectable cytotoxicity observed.	40017003

In Vitro

Cyclocommunol (CYC) (1-5 μM; 24-48 h) potently inhibits the viability of human oral squamous cell carcinoma cell lines SCC2095 and Ca922, with IC₅₀ values of 4.2 μM and 5.0 μM respectively after 48 h of incubation^[1].
Cyclocommunol (compound 1) at concentrations greater than 100 μM shows no detectable cytotoxicity against MCF-7 human breast cancer cells or NCI-H460 human lung cancer cells^[5].
Cyclocommunol (1-5 μM; 48 h) induces concentration-dependent apoptosis in human oral squamous cell carcinoma cell line SCC2095^[1].
Cyclocommunol (1-5 μM; 48 h) activates caspase-dependent apoptosis, induces DNA damage, downregulates the Akt/mTOR pathway in human oral squamous cell carcinoma cell lines SCC2095 and Ca922 after 48 h of incubation, and regulates the expression of pro-apoptotic and anti-apoptotic proteins in SCC2095 cells^[1].
Cyclocommunol (3 μM; 12-48 h) exhibits pro-apoptotic activity that is partially dependent on Mcl-1^[1].
Cyclocommunol (3 μM; 3 h) induces reactive oxygen species production in the human oral squamous cell carcinoma cell line SCC2095^[1].
Cyclocommunol (2-5 μM; 48 h) induces autophagy in the human oral squamous cell carcinoma cell line SCC2095^[1].
Cyclocommunol (compound 5) at 100 μM weakly inhibits 15-LOX activity^[2].
Cyclocommunol (compound 8) potently inhibits GST activity in cell-free biochemical assays, with an IC₅₀ value of 3.0 μM^[3].
Cyclocommunol exhibits weak antibacterial activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Salmonella enterica in agar diffusion assays^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

SCC2095 and Ca922 human oral squamous cell carcinoma cells
Concentration:

1, 2, 3, 5 μM
Incubation Time:

24, 48 h
Result:

Suppressed cell viability in both cell lines in a concentration- and time-dependent manner.

Apoptosis Analysis^[1]

Cell Line:

SCC2095 human oral squamous cell carcinoma cells
Concentration:

1, 2, 3, 5 μM
Incubation Time:

48 h
Result:

Increased the percentage of apoptotic cells in a concentration-dependent manner.

Western Blot Analysis^[1]

Cell Line:

SCC2095 and Ca922 human oral squamous cell carcinoma cells
Concentration:

1, 2, 3, 5 μM
Incubation Time:

48 h
Result:

Caused concentration-dependent PARP cleavage, caspase-9 activation, caspase-3 activation, increased phosphorylation of p53 and H2AX, downregulated phosphorylation of Akt (Ser473) and mTOR (Ser2448), decreased expression of anti-apoptotic proteins Mcl-1 and survivin, and increased expression of pro-apoptotic protein Bax in SCC2095 cells.
Downregulated phosphorylation of Akt and mTOR in a concentration-dependent manner in Ca922 cells.

Cell Autophagy Assay^[1]

Cell Line:

SCC2095 human oral squamous cell carcinoma cells
Concentration:

2, 3, 5 μM
Incubation Time:

48 h
Result:

Induced formation of GFP-LC3 puncta (autophagosomes) at 5 μM.
Caused concentration-dependent upregulation of LC3B-II, p62, and Atg5 protein expression.
Increased the percentage of cells with acidic vesicular organelles to 24.1% at 2 μM and 30.6% at 3 μM.

Western Blot Analysis^[1]

Cell Line:

SCC2095 human oral squamous cell carcinoma cells
Concentration:

3 μM
Incubation Time:

12, 48 h
Result:

Partially reversed cyclocommunol-mediated PARP cleavage and caspase-3 activation via Mcl-1 overexpression.
Partially rescued cell viability from cyclocommunol-induced cytotoxicity via Mcl-1 overexpression.
Decreased Mcl-1 expression in a time-dependent manner at 3 μM over 48 h.

Chemical Information

CAS. Nr. 145643-96-5
Molecular Weight 352.34
Formel C₂₀H₁₆O₆
SMILES

C/C(C)=C\C1C2=C(OC3=C(C(O)=CC(O)=C3)C2=O)C4=CC=C(O)C=C4O1
Structure Classification
- Flavonoids
- Other Flavonoids
Initial Source
- Plants
- Compositae
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (290 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Weng JR, et al. Cyclocommunol induces apoptosis in human oral squamous cell carcinoma partially through a Mcl-1-dependent mechanism. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 Jan 15;39:25-32. [Content Brief]

[2]. Shaha MKK, et al. Flavonoids from the Bark of Artocarpus integer var. silvestris and their Anti-inflammatory Properties. Natural product communications. 2016 Sep;11(9):1275-1278.

[3]. Chad D, et al. Glutathione S-transferase inhibitory, free radical scavenging, and anti-leishmanial activities of chemical constituents of Artocarpus nobilis and Matricaria chamomilla, Phytochemistry Letters, Volume 3, Issue 4, 2010, Pages 207-211, ISSN 1874-3900,

[4]. Siddiq Ur Rahman, et al. Innovative phytochemicals based In-Silico drug design and molecular dynamics simulation targeting norovirus induced gastroenteritis, Journal of Molecular Structure, Volume 1332, 2025, 141733, ISSN 0022-2860,

[5]. Syamsurizal, et al. Semisynthesis and biological activities of derivatives of cyclocommunol from Artocarpus altilis fruit peel. Nat Prod Res. 2026 May;40(9):2402-2409.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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Cyclocommunol

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen

Alle Akt Isoform-spezifische Produkte anzeigen

Alle mTOR Isoform-spezifische Produkte anzeigen