DCZ19931
DCZ19931 is a potent multi-targeting kinase inhibitor. DCZ19931 has anti-angiogenic effects on ocular neovascularization. DCZ19931 also inhibits ERK1/2-MAPK and p38-MAPK signaling.
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- CAS. Nr.: 2789629-84-9
- Formel: C26H20F5N3O5
- Molecular Weight:549.45
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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ERK1 |
ERK2 |
p38 MAPK |
DCZ19931 (1 nM-10 μM; 24 h) shows no obvious cytotoxicity against human umbilical vein endothelial cells (HUVECs)[1].
DCZ19931 (500 nM; 24 h) suppresses (10 ng/mL; 12 h) VEGF-induced proliferation, migration, and tube formation ability of endothelial cells[1].
DCZ19931 (500 nM; 24 h) inhibits vascular permeability via downregulation of ICAM-1 expression[1].
DCZ19931 (500 nM; 24 h) reduces the expression levels of p-ERK1/2, p-p38, and p-JNK in HUVECs[1].
DCZ19931 also shows anti-angiogenic effects in mouse choroidal sprouting assays[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human umbilical vein endothelial cells (HUVECs)
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Concentration:500 nM; with or without 50 ng/mL VEGF for 30 min
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Incubation Time:24 hours
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Result:Decreased expression of phosphorylated ERK and phosphorylated p38.
DCZ19931 (2 μL, 1 μg/μL; intravitreal injection; 7 d) has no tissue toxicity, and inhibits ocular neovascularization in mice with laser-induced choroidal neovascularization (CNV) model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Laser-induced choroidal neovascularization (CNV) model in mice[1]
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Dosage:2 μL, 1 μg/μL
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Administration:Intravitreal injection; single dose, monitored for 7 d following laser photocoagulation
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Result:Did not cause marked histopathological changes in retinal structures.
Decreased the areas of CNV lesions, showed anti-angiogenic effect in vivo.
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Animal Model:Oxygen-induced retinopathy (OIR) model in mice[1]
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Dosage:1 μL, 1 μg/μL
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Administration:Intravitreal injection; single dose
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Result:Further showed anti-angiogenic effect in vivo, inhibited ocular neovascularization.
Chemical Information
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CAS. Nr. 2789629-84-9
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Molecular Weight 549.45
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Formel C26H20F5N3O5
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SMILES
COC1=CC(NC(C(F)(C2=CC=C(C=C2)OC3=C4C=C(C(OC)=CC4=NC=N3)OC)F)=O)=CC(C(F)(F)F)=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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