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Art. -Nr.: HY-W326094

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Dinaline

Name: Dinaline
Brand: MedChemExpress
SKU: HY-W326094
Availability: PreOrder

(Synonyms: GOE 1734; PD 104 208; NSC 328786)

Dinaline (GOE 1734; PD 104 208; NSC 328786) is a potent and orally activity anticancer agent. Dinaline shows cytotoxicity and antitumor activity. Dinaline has the potential for the research of colorectal cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 58338-59-3
Formel: C₁₃H₁₃N₃O
Molecular Weight:227.26

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Dinaline Chemical Structure

CAS. Nr.: 58338-59-3

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

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Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	EC₅₀	12.6 μM Compound: Dinaline	Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis	[PMID: 20966043]
HepG2	EC₅₀	28.2 μM Compound: Dinaline	Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis	[PMID: 20966043]

In Vitro

Dinaline (0.47-15 µg/mL; 48, 27 h) shows cytotoxicity for SW707, SW948 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

SW707, SW948 cells
Concentration:

0.47, 0.95, 1.9, 3.8, 7.5, 15 µg/mL
Incubation Time:

48, 72 h
Result:

Inhibited cell growth with IC₅₀s of 2.2, 1.0 µg/mL at 48 h and 1.2, 0.8 µg/mL at 72 h for SW707, SW948 cells, respectively.

In Vivo

Dinaline (5.9, 7.7, 10 mg/kg; p.o.; 5 days per week for 10 weeks) inhibits tumor growth in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

140-160 g, male Sprague-Dawley rats^[1]
Dosage:

5.9, 7.7, 10 mg/kg
Administration:

P.o.; 5 days per week for 10 weeks
Result:

Showed significant tumor growth inhibition in a dose-dependent manner with the ratio of median tumor volume of (T/C%) values of 0.4, 16 and 10.6 at 10, 7.7 and 5.9 mg/kg respectively.

Chemical Information

CAS. Nr. 58338-59-3
Molecular Weight 227.26
Formel C₁₃H₁₃N₃O
SMILES

O=C(C1=CC=C(C=C1)N)NC2=C(N)C=CC=C2
Synonyms

GOE 1734; PD 104 208; NSC 328786
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Seelig MH, et al. Efficacy of dinaline and its methyl and acetyl derivatives against colorectal cancer in vivo and in vitro. Eur J Cancer. 1996 Oct;32A(11):1968-76. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
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- In Vivo
Chemical Information
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Dinaline

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