Divarin
Based on 1 Customer Validation
Divarin (5-Propylbenzene-1,3-diol) is an important precursor and intermediate in the synthesis of cannabinoids, and is present in certain bacteria and lichens. Divarin exhibits antioxidant activity. Divarin acts as an electron acceptor to directly scavenge superoxide anions and modulates the transcription of oxidative stress genes such as soxS, thereby enhancing bacterial resistance to late-stage reactive oxygen species (ROS) through a non-enzymatic mechanism. Divarin can be used in research on antioxidant development.
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- Reinheit : 99.35%
- CAS. Nr.: 500-49-2
- Formel: C9H12O2
- Molecular Weight:152.19
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Speicherung:
RT, stored under nitrogen.
In solvent -80°C, 1 year , -20°C, 6 months
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Beschreibung
In Vitro
Divarin (1 μM-1 mM; pre-incubation for 60 min and 60 min under PQ stimulation) modulates soxS gene expression and enhances antioxidant stress survival in PQ (HY-B0864A)-treated E. coli K12 MG1655 psoxS'::luxCDABE-Amp bacterial cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:E. coli K12 MG1655 psoxS'::luxCDABE-Amp strain
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Concentration:1 μM, 10 μM, 0.1 mM, 1 mM
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Incubation Time:pre-incubated for 60 minutes, followed by paraquat (PQ) stimulation for 60 minutes
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Result:Paradoxically and significantly increased bacterial survival under PQ-induced oxidative stress (increasing the number of surviving cells by 16.1% to 40.9% compared to the control group).
Chemical Information
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CAS. Nr. 500-49-2
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Appearance Solid
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Molecular Weight 152.19
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Formel C9H12O2
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Color Light brown to brown
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SMILES
OC1=CC(CCC)=CC(O)=C1
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Synonyms
5-Propylbenzene-1,3-diol
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
RT, stored under nitrogen
In solvent -80°C 1 year -20°C 6 months
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 100 mg/mL (657.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.5707 mL | 32.8537 mL | 65.7073 mL | 164.2683 mL |
| 5 mM | 1.3141 mL | 6.5707 mL | 13.1415 mL | 32.8537 mL | |
| 10 mM | 0.6571 mL | 3.2854 mL | 6.5707 mL | 16.4268 mL | |
| 15 mM | 0.4380 mL | 2.1902 mL | 4.3805 mL | 10.9512 mL | |
| 20 mM | 0.3285 mL | 1.6427 mL | 3.2854 mL | 8.2134 mL | |
| 25 mM | 0.2628 mL | 1.3141 mL | 2.6283 mL | 6.5707 mL | |
| 30 mM | 0.2190 mL | 1.0951 mL | 2.1902 mL | 5.4756 mL | |
| 40 mM | 0.1643 mL | 0.8213 mL | 1.6427 mL | 4.1067 mL | |
| 50 mM | 0.1314 mL | 0.6571 mL | 1.3141 mL | 3.2854 mL | |
| 60 mM | 0.1095 mL | 0.5476 mL | 1.0951 mL | 2.7378 mL | |
| 80 mM | 0.0821 mL | 0.4107 mL | 0.8213 mL | 2.0534 mL | |
| 100 mM | 0.0657 mL | 0.3285 mL | 0.6571 mL | 1.6427 mL |
Divarin Related Classifications
HY-W110493 Related Classifications
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Keywords
- Divarin
- 500-49-2
- 5-Propylbenzene-1,3-diol
- Drug Intermediate
- Endogenous Metabolite
- Reactive Oxygen Species (ROS)
- Bacterial
- E. coli
- alkylresorcinol
- bacterial cell viability
- nitroblue tetrazolium
- oxidative stress
- paraquat
- sox regulon transcription
- soxS gene expression
- soxS-dependent bioluminescence
- superoxide anion
- Inhibitor
- inhibitor
- inhibit