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Art. -Nr.: HY-148350

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DS69910557

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DS69910557 is a potent, selective and orally activehuman parathyroid hormone receptor 1 (hPTHR1) antagonist. DS69910557 has antagonistic activity for PTHR1 with an IC₅₀ value of 0.08 μM. DS69910557 can be used for the research of hyperparathyroidism, hypercalcemia of malignancy and osteoporosis.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 98.86%
CAS. Nr.: 3032750-17-4
Formel: C₃₂H₃₃Cl₂FN₄O₃
Molecular Weight:611.53

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

DS69910557 Chemical Structure

CAS. Nr.: 3032750-17-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC50: 0.08 μM (PTHR1)^[1].

Alle PTHR Isoform-spezifische Produkte anzeigen :

PTH1R
PTH2R

In Vitro

DS69910557 (compound 19e) has highly potent antagonistic activity for PTHR1 with an IC₅₀ value of 0.08 μM^[1].
DS69910557 (3 μM) exhibits excellent selectivity against human ether-a-go-go-related-gene (hERG) channel^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DS69910557 (compound 19e) (p.o.; 5mg/kg) has potency to decrease the plasma calcium concentration in rats in vivo^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Rats^[1]
Dosage:

5mg/kg
Administration:

PO
Result:

Showed excellent PK profile, high maximum plasma concentration and plasma exposure in rats.

Chemical Information

CAS. Nr. 3032750-17-4
Appearance Solid
Molecular Weight 611.53
Formel C₃₂H₃₃Cl₂FN₄O₃
Color Off-white to light yellow
SMILES

ClC(C=N1)=CC(C2=C(C=C(Cl)C=C2)N3C4=CC=C(N5CC(F)(CN[C@@H]6CC[C@@H](C(O)=O)CC6)C5)C=C4)=C1C(C)(C)C3=O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (163.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.6352 mL

8.1762 mL

16.3524 mL

5 mM

0.3270 mL

1.6352 mL

3.2705 mL

10 mM

0.1635 mL

0.8176 mL

1.6352 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Yoshikazu Arai, et al. Lead optimization of pyrido[2,3-d][1]benzazepin-6-one derivatives leading to the discovery of a potent, selective, and orally available human parathyroid hormone receptor 1 (hPTHR1) antagonist (DS69910557). Bioorg Med Chem. 2022 Jun 15;64:116763. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.6352 mL	8.1762 mL	16.3524 mL	40.8811 mL
	5 mM	0.3270 mL	1.6352 mL	3.2705 mL	8.1762 mL
	10 mM	0.1635 mL	0.8176 mL	1.6352 mL	4.0881 mL
	15 mM	0.1090 mL	0.5451 mL	1.0902 mL	2.7254 mL
	20 mM	0.0818 mL	0.4088 mL	0.8176 mL	2.0441 mL
	25 mM	0.0654 mL	0.3270 mL	0.6541 mL	1.6352 mL
	30 mM	0.0545 mL	0.2725 mL	0.5451 mL	1.3627 mL
	40 mM	0.0409 mL	0.2044 mL	0.4088 mL	1.0220 mL
	50 mM	0.0327 mL	0.1635 mL	0.3270 mL	0.8176 mL
	60 mM	0.0273 mL	0.1363 mL	0.2725 mL	0.6814 mL
	80 mM	0.0204 mL	0.1022 mL	0.2044 mL	0.5110 mL
	100 mM	0.0164 mL	0.0818 mL	0.1635 mL	0.4088 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
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DS69910557

GPCR/G Protein Compound Library

Anti-Cancer Compound Library

Endocrinology Compound Library

Orally Active Compound Library

Osteogenesis Compound Library

Highly Selective Inhibitors Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

Alle PTHR Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

DS69910557

GPCR/G Protein Compound Library

Anti-Cancer Compound Library

Endocrinology Compound Library

Orally Active Compound Library

Osteogenesis Compound Library

Highly Selective Inhibitors Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

Alle PTHR Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

DS69910557 Related Classifications

HY-148350 Related Classifications