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Art. -Nr.: HY-184150

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EN10

EN10 is a ligand for the muscle-specific E3 ligase KLHL41, which can be used to synthesize PROTAC KBD-1 (HY-184151) targeting BRD4.

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CAS. Nr.: 2093466-80-7
Formel: C₂₁H₂₃N₃O
Molecular Weight:333.43

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

EN10 Chemical Structure

CAS. Nr.: 2093466-80-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
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Beschreibung

EN10 is a ligand for the muscle-specific E3 ligase KLHL41, which can be used to synthesize PROTAC KBD-1 (HY-184151) targeting BRD4^[1].

IC₅₀ & Target

^[1]

KLHL41

Alle Ligands for E3 Ligase Isoform-spezifische Produkte anzeigen :

In Vitro

EN10 (5-15 μM; 30 min) selectively binds to KLHL41 (but not KLHL40) in live RH30 human muscle rhabdomyosarcoma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Chemical Information

CAS. Nr. 2093466-80-7
Molecular Weight 333.43
Formel C₂₁H₂₃N₃O
SMILES

[C@@H]1(C2=CC=CC=C2)OCC[C@H]1CNCC3=CNN=C3C4=CC=CC=C4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Yim J, et al. Discovery of a KLHL41 Ligand for Muscle Specific Protein Degradation. Nat Commun. 2026;17(1):4551. Published 2026 May 26. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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EN10

Alle Ligands for E3 Ligase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

IC50 & Target

In Vitro

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

EN10 Related Classifications

HY-184150 Related Classifications

Bioz

Keywords

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