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Art. -Nr.: HY-P99360

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Biologically Validated

Enapotamab

(Synonyms: Anti-AXL/UFO Reference Antibody (enapotamab))

Kundenbewertung

Based on 1 Customer Validation

Enapotamab (Anti-AXL/UFO Reference Antibody) is an AXL/UFO-related antibody that can be used for synthesis of ADC molecule Enapotamab vedotin (HY-P99921).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.9%
CAS. Nr.: 1912423-61-0
Molecular Weight:143.895 kDa

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Enapotamab Chemical Structure

CAS. Nr.: 1912423-61-0

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Preis

Verfügbarkeit

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Biologische Aktivität
- Beschreibung
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Anwendung
- Verified Bioactivity
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Enapotamab (Anti-AXL/UFO Reference Antibody) is an AXL/UFO-related antibody that can be used for synthesis of ADC molecule Enapotamab vedotin (HY-P99921)^[1].

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

Axl

Alle TAM Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

Enapotamab can be used as the ADC antibody of Enapotamab vedotin (HY-P99921).
Enapotamab vedotin exhibits cytotoxicity in AXL high expressing NSCLC cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Enapotamab vedotin exhibits antitumor efficacy against various NSCLC tumors with high AXL expression, also exhibits resistant to EGFR inhibitor in LU1868 xenograft mouse models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Gene ID

558 [NCBI]

Accession

P30530

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Human IgG1 kappa

Anwendung

ELISA, FACS, Functional assay

Verified Bioactivity

Loaded Enapotamab on AHC2 biosensor, can bind AXL Protein, Human (449a.a, HEK293, His, HY-P74407) with an affinity constant of 6.653E-09 M as determined in BLI assay.
Immobilized AXL Protein, Human (HEK293, His, HY-P74407) can bind Enapotamab. The EC₅₀ for this effect is 0.3126 ng/mL.

Chemical Information

CAS. Nr. 1912423-61-0
Appearance Liquid
Molecular Weight 143.895 kDa
Color Colorless to light yellow
SMILES

[Enapotamab]
Synonyms

Anti-AXL/UFO Reference Antibody (enapotamab)
Versand

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (257 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Verweise

[1]. Matthew T. Burger, et al. Bcl-xl inhibitor antibody-drug conjugates and methods of use thereof. WO2022115477A1.

[2]. Koopman LA, et al. Enapotamab vedotin, an AXL-specific antibody-drug conjugate, shows preclinical antitumor activity in non-small cell lung cancer. JCI Insight. 2019 Nov 1;4(21):e128199. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Anwendung
- Biological Activity
Chemical Information
Reinheit & Dokumentation
Verweise

1/16

Human IgG1 kappa
1/16

Loaded Enapotamab on AHC2 biosensor, can bind AXL Protein, Human (449a.a, HEK293, His, HY-P74407) with an affinity constant of 6.653E-09 M as determined in BLI assay.
1/16

Immobilized AXL Protein, Human (HEK293, His, HY-P74407) can bind Enapotamab. The EC₅₀ for this effect is 0.3126 ng/mL.
1/16

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Enapotamab

Cell-ATP Viability Detection Kit

Protein A Agarose

HOLO Human Interleukin-2 (IL-2) Detection Kit

Bradford Protein Assay Kit

PBS Buffer (1×)

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

Antibody Inhibitor Library

Alle TAM Receptor Isoform-spezifische Produkte anzeigen