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Art. -Nr.: HY-117543

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Ethonafide

Name: Ethonafide
Brand: MedChemExpress
SKU: HY-117543
Availability: PreOrder

(Synonyms: AMP-53; 6-Ethoxyazonafide)

Ethonafide (AMP-53) is an anthracene-containing derivative of Amonafide that belongs to the Azonafide series of anticancer agents. Ethonafide (AMP-53) inhibits topoisomerase II activity by stabilizing the enzyme-DNA complex, involving both topoisomerase IIα and β.

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CAS. Nr.: 160554-87-0
Formel: C₂₂H₂₂N₂O₃
Molecular Weight:362.42

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Ethonafide Chemical Structure

CAS. Nr.: 160554-87-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Topoisomerase Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	2.9 nM Compound: 24	Tested against A549 lung carcinoma in the sulforhodamine B assay. Tested against A549 lung carcinoma in the sulforhodamine B assay.	[PMID: 8648600]
L1210	IC₅₀	6.7 nM Compound: 24	Inhibitory activity against resistant murine leukemia L1210 cell lines. Inhibitory activity against resistant murine leukemia L1210 cell lines.	[PMID: 8648600]
L1210	IC₅₀	8 nM Compound: 24	Inhibitory activity against sensitive L1210 cell lines Inhibitory activity against sensitive L1210 cell lines	[PMID: 8648600]
L1210	IC₅₀	9.3 nM Compound: 24	An average for IC50 values in the two solid tumor cell lines and sensitive L1210 leukemia cell line. An average for IC50 values in the two solid tumor cell lines and sensitive L1210 leukemia cell line.	[PMID: 8648600]
MCF7	IC₅₀	11 nM Compound: 24	Tested against MXF7 breast carcinoma (sensitive) cell line in the sulforhodamine B assay. Tested against MXF7 breast carcinoma (sensitive) cell line in the sulforhodamine B assay.	[PMID: 8648600]
MCF7	IC₅₀	14 nM Compound: 24	Tested against MXF7 breast carcinoma (mitoxantrone resistant)cell line in the sulforhodamine B assay. Tested against MXF7 breast carcinoma (mitoxantrone resistant)cell line in the sulforhodamine B assay.	[PMID: 8648600]
MCF7	IC₅₀	18 nM Compound: 24	Tested against MXF7 breast carcinoma (doxorubicin resistant) cell line in the sulforhodamine B assay. Tested against MXF7 breast carcinoma (doxorubicin resistant) cell line in the sulforhodamine B assay.	[PMID: 8648600]
OVCAR-3	IC₅₀	0.8 nM Compound: 24	Inhibitory activity against OVCAR-3 cell line Inhibitory activity against OVCAR-3 cell line	[PMID: 8648600]
UACC-375	IC₅₀	19 nM Compound: 24	Inhibitory activity against AUC375 cell line Inhibitory activity against AUC375 cell line	[PMID: 8648600]
WiDr	IC₅₀	17 nM Compound: 24	Tested against WiDr colon (sensitive) in the sulforhodamine B assay. Tested against WiDr colon (sensitive) in the sulforhodamine B assay.	[PMID: 8648600]
WiDr	IC₅₀	63 nM Compound: 24	Tested against WiDr colon carcinoma (resistant) in the sulforhodamine B assay. Tested against WiDr colon carcinoma (resistant) in the sulforhodamine B assay.	[PMID: 8648600]

Chemical Information

CAS. Nr. 160554-87-0
Molecular Weight 362.42
Formel C₂₂H₂₂N₂O₃
SMILES

O=C1N(CCN(C)C)C(C2=CC=C(OCC)C3=CC4=CC=CC=C4C1=C23)=O
Synonyms

AMP-53; 6-Ethoxyazonafide
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Alan Pourpak, et al. Ethonafide-induced cytotoxicity is mediated by topoisomerase II inhibition in prostate cancer cells. J Pharmacol Exp Ther. 2007 Jun;321(3):1109-17. [Content Brief]

[2]. S M Sami, et al. 6- and 7-substituted 2-[2'-(dimethylamino)ethyl]-1,2-dihydro-3H-dibenz[de,h] isoquinoline-1,3-diones: synthesis, nucleophilic displacements, antitumor activity, and quantitative structure-activity relationships. J Med Chem. 1996 Apr 12;39(8):1609-18. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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