Gallamine
Gallamine is an allosteric, selective muscarinic M2 acetylcholine receptor antagonist (EC50: 130 nM for [3H]NMS dissociation from porcine muscarinic M2 receptors). Gallamine is also an acetylcholinesterase inhibitor (IC50s : 1070 μM, 1480 μM, 235 μM for EeAChE, hAChE, hBChE, respectively (in the absence of MeCN)). Gallamine increases free norepinephrine levels. Gallamine can be used as a muscle relaxant.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 153-76-4
- Formel: C24H45N3O3
- Molecular Weight:423.63
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
|
mAChR2 130 nM (EC50) |
EeAChE 1070 μM (IC50) |
hAChE 1480 μM (IC50) |
Chemical Information
-
CAS. Nr. 153-76-4
-
Molecular Weight 423.63
-
Formel C24H45N3O3
-
SMILES
CCN(CC)CCOC1=C(OCCN(CC)CC)C(OCCN(CC)CC)=CC=C1
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Elsinghorst PW, et al. First gallamine-tacrine hybrid: design and characterization at cholinesterases and the M2 muscarinic receptor. J Med Chem. 2007 Nov 15;50(23):5685-95. [Content Brief]
[2]. Matsuki A, et al. Effect of gallamine on plasma cortisol and catecholamine levels in man. Can Anaesth Soc J. 1973 Jul;20(4):539-45. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Powered by Bioz